• 1. Improved photon absorption in dye-functionalized silicon nanocrystals synthesized via microwave-assisted hydrosilylation
  Deski Beri,Marius Jakoby,Ian A. Howard,Dmitry Busko,Bryce S. Richards,Andrey Turshatov Dalton Trans. 2020 49 2290
• 2. Fundamental studies to emerging applications of pyrrole-BF2 (BOPHY) fluorophores
  Aisha N. Bismillah,Ivan Aprahamian Chem. Soc. Rev. 2021 50 5631
• 3. Photophysical and structural investigation of a PyA-modified adenine cluster: its potential use for fluorescent DNA probes exhibiting distinct emission color changes
  Ki Tae Kim,Wooseok Heo,Taiha Joo,Byeang Hyean Kim Org. Biomol. Chem. 2015 13 8470

Perylene, 3-ethynyl- (CAS No. 132196-66-8): A Versatile Compound in Modern Chemical Research

Perylene, 3-ethynyl-, with the chemical formula C₂₀H₁₂N and CAS number 132196-66-8, is a highly intriguing molecule that has garnered significant attention in the field of chemical biology and materials science. This compound, a derivative of perylene, a polycyclic aromatic hydrocarbon (PAH), exhibits unique structural and electronic properties that make it invaluable for various applications, including optoelectronic devices, photodynamic therapy, and as a building block for more complex molecular architectures.

The structure of Perylene, 3-ethynyl features a perylene core substituted with an ethynyl group at the 3-position. This ethynyl functionality introduces a site for further chemical modification, enabling the synthesis of a wide range of derivatives with tailored properties. The perylene core itself is known for its high thermal stability, excellent light absorption characteristics, and ability to form stable π-stacking interactions, making it an ideal candidate for applications in organic electronics.

In recent years, the chemical biology applications of Perylene, 3-ethynyl have been extensively explored. One of the most notable areas is its use as a photosensitizer in photodynamic therapy (PDT). PDT is a medical treatment that uses light-sensitive dyes to produce reactive oxygen species upon irradiation with light, leading to the destruction of cancer cells. The high molar extinction coefficient and strong absorption in the near-infrared region of the spectrum make Perylene, 3-ethynyl an excellent candidate for this purpose. Recent studies have demonstrated its efficacy in targeting and destroying tumor cells while minimizing damage to surrounding healthy tissue.

Furthermore, the optoelectronic properties of Perylene, 3-ethynyl have been leveraged in the development of organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs). The compound's ability to form stable π-stacking interactions allows for efficient charge transport, which is crucial for the performance of these devices. In OLEDs, Perylene, 3-ethynyl has been used as a host material or dopant to improve electroluminescence efficiency. Similarly, in OPVs, it has been employed as a donor material due to its favorable energy levels and hole-transporting capabilities.

The synthesis of Perylene, 3-ethynyl can be achieved through various methods, including palladium-catalyzed cross-coupling reactions such as Sonogashira coupling. This reaction involves the coupling of an acetylide with an aryl halide or triflate under palladium catalysis to form an alkyne. The Sonogashira coupling reaction is particularly useful for introducing the ethynyl group into the perylene core. Other synthetic approaches include electrochemical methods and photocatalytic processes, which offer advantages in terms of selectivity and mild reaction conditions.

Recent advancements in material science have highlighted the potential of Perylene, 3-ethynyl as a component in advanced materials. For instance, it has been incorporated into polymers and nanoparticles to enhance their optical and electronic properties. These materials have found applications in sensors, catalysts, and even in the development of novel drug delivery systems. The ability to tune the properties of these materials by modifying the structure of Perylene, 3-ethynyl makes it a highly versatile building block.

The biological activity of Perylene, 3-ethynyl has also been studied extensively. While perylenes are known for their potential toxicity due to their PAH structure, modifications such as the introduction of an ethynyl group can alter their biological profile. Research has shown that certain derivatives can exhibit anti-inflammatory and anti-proliferative effects. These findings have opened up new avenues for exploring Perylene, 3-ethynyl as a lead compound for drug discovery.

In conclusion, Perylene, 3-ethynyl (CAS No. 132196-66-8) is a multifaceted compound with significant potential in various fields of research. Its unique structural and electronic properties make it an invaluable tool for developing new materials and therapies. As research continues to uncover more about its capabilities, Perylene, 3-ethynyl is likely to play an increasingly important role in advancing both chemical biology and materials science.

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