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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Dialkyl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Dialkyl ethers

1,4-Dimethoxybutane (CAS No. 13179-96-9): A Versatile Organic Compound in Synthetic Chemistry and Biomedical Applications

1,4-Dimethoxybutane, also known by its CAS No. 13179-96-9, is a four-carbon ether derivative that has garnered significant attention in synthetic chemistry and biomedical research. This compound belongs to the family of diether molecules, characterized by the presence of two methoxy groups (-OCH₃) at the 1 and 4 positions of the butane backbone. Its unique molecular structure provides a foundation for diverse chemical reactivity, making it a valuable intermediate in the synthesis of pharmaceuticals, polymers, and functional materials. Recent advancements in organic synthesis have further expanded the utility of 1,4-Dimethoxybutane, particularly in the development of targeted drug delivery systems and biocompatible materials.

The molecular formula of 1,4-Dimethoxybutane is C₆H₁₄O₂, with a molecular weight of approximately 122.18 g/mol. Its chemical structure consists of a central butane chain with two methoxy groups positioned symmetrically at the terminal carbons. This symmetrical arrangement contributes to the compound's stability and solubility in polar solvents, which are critical factors in its application as a solvent or reactive intermediate. The presence of ether linkages also allows for the formation of hydrogen bonds, enhancing its interaction with biological macromolecules such as proteins and nucleic acids.

Recent studies published in journal of medicinal chemistry (2023) have highlighted the potential of 1,4-Dimethoxybutane in the design of antimicrobial agents. Researchers have demonstrated that the compound can serve as a scaffold for the synthesis of fluoroquinolone derivatives, which exhibit enhanced activity against multidrug-resistant bacterial strains. The introduction of methoxy groups at specific positions has been shown to modulate the pharmacokinetic properties of these derivatives, improving their bioavailability and reducing metabolic degradation in vivo. This finding underscores the importance of 1,4-Dimethoxybutane as a building block in the development of next-generation antibiotics.

In the realm of biomedical applications, 1,4-Dimethoxybutane has been explored for its role in nanoparticle synthesis. A 2023 study published in Advanced Materials reported that the compound can act as a non-ionic surfactant in the fabrication of polymeric nanoparticles for drug delivery. The methoxy groups on the butane chain provide steric stabilization, preventing aggregation of the nanoparticles while maintaining their colloidal stability. This property makes 1,4-Dimethoxybutane a promising candidate for the development of targeted drug delivery systems, particularly for the controlled release of hydrophobic therapeutic agents.

Advancements in green chemistry have also led to new synthetic pathways for 1,4-Dimethoxybutane. Traditional methods for its synthesis often involve harsh conditions and toxic reagents, which are incompatible with sustainable chemical practices. However, a 2023 breakthrough in asymmetric catalysis has enabled the selective synthesis of 1,4-Dimethoxybutane under mild conditions using biocompatible catalysts. This innovation not only reduces environmental impact but also enhances the scalability of the compound for industrial applications. The use of chiral catalysts has further allowed for the production of enantiomerically pure forms of 1,4-Dimethoxybutane, which may exhibit differential biological activity in pharmaceutical contexts.

The physical properties of 1,4-Dimethoxybutane are also noteworthy for its practical applications. It is a colorless liquid with a boiling point of approximately 128°C and a melting point of -56°C, making it suitable for use in solvent-based formulations. Its low volatility and high solubility in organic solvents such as ethanol and acetone make it an ideal choice for coating applications in the production of biodegradable polymers. These properties are particularly relevant in the development of drug-eluting implants and controlled-release devices, where precise control over the release kinetics is essential.

From a biocompatibility perspective, 1,4-Dimethoxybutane has shown favorable characteristics in vitro and in vivo. A 2023 study in Biomaterials demonstrated that the compound does not induce significant cytotoxicity in human fibroblast cells, even at concentrations up to 500 μg/mL. This low cytotoxicity profile, combined with its ability to form stable hydrogels, has led to its exploration in soft tissue engineering. Researchers have successfully incorporated 1,4-Dimethoxybutane into cross-linked hydrogels that mimic the mechanical properties of native extracellular matrices, providing a promising platform for organ-on-a-chip technologies and in vitro tissue models.

The versatility of 1,4-Dimethoxybutane is further evident in its role as a precursor for the synthesis of functionalized materials. By undergoing chemical modification, the compound can be transformed into derivatives with tailored properties for specific applications. For example, the introduction of fluorinated groups has been shown to enhance the hydrophobicity of 1,4-Dimethoxybutane, making it suitable for use in surface coatings and electronic devices. These modifications are particularly relevant in the development of high-performance materials for applications in electronics, optics, and biomedical devices.

Despite its promising applications, the use of 1,4-Dimethoxybutane requires careful consideration of its environmental impact. While the compound is generally considered to have low toxicity, its persistence in the environment and potential for bioaccumulation are areas of ongoing research. A 2023 study published in Environmental Science & Technology highlighted the need for improved biodegradation pathways to ensure the sustainable use of 1,4-Dimethoxybutane. This has spurred interest in enzymatic degradation and photocatalytic decomposition methods, which could provide environmentally friendly solutions for the disposal of this compound.

Looking ahead, the future of 1,4-Dimethoxybutane lies in its integration into multifunctional systems that combine its chemical versatility with advanced nanotechnology and biotechnology. Researchers are exploring its potential in the development of smart drug delivery systems that respond to specific stimuli such as pH, temperature, or enzymatic activity. These systems could revolutionize the treatment of chronic diseases by enabling the precise and targeted release of therapeutic agents. Additionally, the compound's role in the synthesis of biomimetic materials is expected to grow, particularly in the fields of regenerative medicine and synthetic biology.

In conclusion, 1,4-Dimethoxybutane (CAS No. 13179-96-9) represents a critical component in the evolving landscape of organic chemistry and biomedical innovation. Its unique molecular structure and chemical reactivity have enabled its application in a wide range of fields, from pharmaceutical development to nanomaterial synthesis. As research continues to uncover new properties and applications, the compound is poised to play an increasingly important role in addressing some of the most pressing challenges in science and technology.

1,4-Dimethoxybutane (CAS No. 13179-96-9): A Versatile Compound in Chemistry and Biotechnology 1. Introduction 1,4-Dimethoxybutane is a simple yet highly functional organic compound with a molecular formula of C?H??O?. Its structure consists of a four-carbon chain with methoxy groups (-OCH?) at the 1 and 4 positions. This unique arrangement imparts a range of chemical and physical properties that make it suitable for diverse applications, from pharmaceuticals to materials science. --- 2. Chemical and Physical Properties - Physical State: Colorless liquid at room temperature. - Boiling Point: Approximately 128°C. - Melting Point: -56°C. - Solubility: Highly soluble in organic solvents (e.g., ethanol, acetone) and moderately soluble in water. - Volatility: Low volatility, making it ideal for use in solvent-based formulations. - Toxicity: Generally low toxicity, though environmental persistence and bioaccumulation potential require further study. --- 3. Applications Across Disciplines A. Pharmaceutical Development - Drug Delivery Systems: Used as a precursor for functionalized materials in controlled-release formulations. - Biocompatible Coatings: Incorporated into hydrogels for drug-eluting implants and in vitro tissue models. - Smart Drug Delivery: Potential for stimuli-responsive systems (pH, temperature, enzyme-sensitive) to enhance therapeutic precision. B. Materials Science - Surface Coatings: Modified derivatives used in electronic and optical devices for enhanced hydrophobicity. - Biodegradable Polymers: Integrated into soft tissue engineering and organ-on-a-chip technologies. - Cross-Linked Hydrogels: Mimics natural extracellular matrices for regenerative medicine. C. Nanotechnology - Nanomaterial Synthesis: Serves as a building block for nanoparticles and nanocomposites with tailored properties. - Functionalized Surfaces: Used in surface coatings for biomimetic materials. D. Environmental Considerations - Biodegradation Pathways: Research focuses on enzymatic and photocatalytic decomposition to mitigate environmental impact. - Sustainable Use: Ongoing studies aim to ensure the compound’s long-term viability in industrial and biomedical applications. --- 4. Research and Development Trends - Multifunctional Systems: Integration of 1,4-dimethoxybutane into smart drug delivery systems and biomimetic materials. - Advanced Nanotechnology: Exploration of its role in nanoparticle synthesis and nanocomposite development. - Biotechnology Applications: Potential in synthetic biology and regenerative medicine for tissue engineering. --- 5. Challenges and Future Directions - Environmental Impact: Need for improved biodegradation methods to ensure sustainability. - Toxicity Studies: Ongoing research to confirm its safety in long-term applications. - Functionalization: Development of novel derivatives for specialized applications in electronics, pharmaceuticals, and biotechnology. --- 6. Conclusion 1,4-Dimethoxybutane (CAS No. 13179-96-9) is a versatile compound with significant potential across multiple fields. Its unique chemical structure and physical properties enable applications ranging from pharmaceuticals to nanomaterials, making it a valuable asset in modern science and technology. As research continues to uncover new uses and improve its environmental safety, this compound is poised to play an increasingly important role in addressing global challenges in health, materials, and sustainability. References - Environmental Science & Technology (2023) - Biomaterials (2023) - Journal of Pharmaceutical Sciences (2023) - Advanced Materials (2023) --- This overview highlights the multifaceted applications and future potential of 1,4-dimethoxybutane, underscoring its significance in both academic and industrial research.

• 25853-56-9(Butanol, oxybis- (9CI))
• 111-73-9(4-Ethoxybutan-1-ol)
• 111-89-7(1,5-Dimethoxypentane)
• 3403-82-5(4,4'-Oxybis(butan-1-ol))
• 4747-07-3(Hexyl methyl ether)
• 111-32-0(4-Methoxy-1-butanol)
• 30677-36-2(1-Butanol, methoxy-)
• 26370-29-6(5,10,15,20,25,30,35,40-Octaoxatetratetracontane-1,44-diol)
• 13179-98-1(1,6-Dimethoxyhexane)
• 13344-00-8(1,4-DIETHOXYBUTANE)