• 1. Distinction of trans–cis photoisomers with comparable optical properties in multiple-state photochromic systems – examining a molecule with three azobenzenes via in situ irradiation NMR spectroscopy?
  Jonas Kind,Lukas Kaltschnee,Martin Leyendecker,Christina M. Thiele Chem. Commun., 2016,52, 12506-12509
• 2. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 3. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 4. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 5. Emerging investigators
  Polym. Chem., 2015,6, 5501-5502

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Comprehensive Overview of N-(4-Chlorophenyl)glycine methyl ester (CAS No. 131770-31-5)

N-(4-Chlorophenyl)glycine methyl ester (CAS No. 131770-31-5) is a specialized organic compound widely utilized in pharmaceutical and agrochemical research. This ester derivative of glycine is characterized by its 4-chlorophenyl substitution, which enhances its reactivity and applicability in synthetic chemistry. Researchers and industry professionals frequently seek information on its synthesis methods, physicochemical properties, and applications in drug discovery, making it a topic of significant interest in modern chemical literature.

The compound's molecular structure, featuring a methyl ester group and a chlorinated aromatic ring, contributes to its versatility as a building block in organic synthesis. Recent studies highlight its role in the development of bioactive molecules, particularly in the design of enzyme inhibitors and antimicrobial agents. With growing interest in green chemistry, questions about its environmental impact and sustainable production methods have become prevalent in scientific discussions.

Analytical techniques such as HPLC, NMR spectroscopy, and mass spectrometry are commonly employed to characterize N-(4-Chlorophenyl)glycine methyl ester. Its solubility profile (soluble in organic solvents like methanol and DMSO) and stability under various conditions are frequently queried by laboratory technicians. The compound's melting point range (typically 80-85°C) and molecular weight (213.66 g/mol) are critical parameters for quality control in industrial applications.

In pharmaceutical contexts, this compound serves as a precursor for heterocyclic compounds with potential therapeutic effects. Recent patent filings reveal its utility in developing central nervous system (CNS) drugs, aligning with current research trends targeting neurodegenerative diseases. The chlorophenyl moiety enhances membrane permeability, a property highly valued in drug design optimization strategies.

From a commercial perspective, N-(4-Chlorophenyl)glycine methyl ester is available through specialty chemical suppliers with varying purity grades (typically 95-99%). Market analyses indicate rising demand correlated with increased R&D investment in small molecule therapeutics. Proper storage conditions (recommended 2-8°C in airtight containers) and handling precautions are frequently discussed in technical datasheets to maintain compound integrity.

Emerging applications in material science have expanded the compound's relevance beyond life sciences. Its aromatic structure makes it a candidate for organic semiconductor development, particularly in optoelectronic devices. This interdisciplinary potential has generated increased academic interest, with numerous studies investigating its photophysical properties and crystal packing behavior.

Quality assessment protocols for CAS No. 131770-31-5 typically include chromatographic purity tests and residual solvent analysis. Regulatory compliance documentation often addresses REACH registration status and GHS classification, important considerations for international trade. The compound's structure-activity relationships continue to be explored through computational chemistry approaches, including molecular docking studies.

Recent scientific literature emphasizes the compound's role in combinatorial chemistry libraries, particularly for high-throughput screening platforms. Its moderate lipophilicity (calculated logP ~2.1) positions it favorably for medicinal chemistry applications. Technical forums frequently discuss optimal purification methods, with flash chromatography and recrystallization being common approaches for laboratory-scale preparation.

The future research trajectory for N-(4-Chlorophenyl)glycine methyl ester appears promising, with potential applications in bioconjugation chemistry and prodrug design. As synthetic methodologies advance, particularly in catalytic amidation techniques, production efficiency improvements are anticipated. These developments align with broader industry movements toward atom-economical processes and waste reduction in fine chemical manufacturing.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)