• 1. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 2. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 3. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 4. Alumina grafted SBA-15 sustainable bifunctional catalysts for direct cross-coupling of benzylic alcohols to diarylmethanes?
  Chandran Rajendran,Govindaswamy Satishkumar,Charlotte Lang,Eric M. Gaigneaux Catal. Sci. Technol., 2020,10, 2583-2592
• 5. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyridazines and derivatives Aminopyridazines

Comprehensive Overview of (6-Aminopyridazin-3-yl)methanol (CAS No. 1314912-56-5): Properties, Applications, and Research Insights

(6-Aminopyridazin-3-yl)methanol (CAS No. 1314912-56-5) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research. This pyridazine derivative features a hydroxylmethyl group at the 3-position and an amino group at the 6-position, making it a versatile intermediate for synthesizing bioactive molecules. Its molecular formula, C₅H₇N₃O, and unique structure contribute to its relevance in drug discovery programs targeting kinase inhibitors and antimicrobial agents.

Recent studies highlight the compound's role in developing small-molecule therapeutics, particularly in oncology and infectious diseases. Researchers are exploring its potential as a scaffold for selective enzyme modulators, leveraging its hydrogen-bonding capabilities. The aminopyridazine core is also investigated for crop protection chemicals, aligning with the growing demand for sustainable agriculture solutions—a hot topic in 2024.

From a synthetic chemistry perspective, (6-Aminopyridazin-3-yl)methanol serves as a key precursor for N-functionalized pyridazines. Its reactivity allows for modifications at both the amino and alcohol functionalities, enabling the creation of diverse structure-activity relationship (SAR) libraries. This adaptability addresses the pharmaceutical industry's need for highly tunable pharmacophores, a frequent search query among medicinal chemists.

Analytical characterization of CAS No. 1314912-56-5 typically involves HPLC purity analysis, mass spectrometry, and NMR spectroscopy—techniques commonly discussed in online forums about compound verification. The compound's stability under various pH conditions makes it suitable for formulation development, another trending subject in pharmaceutical manufacturing communities.

Environmental and regulatory aspects of (6-Aminopyridazin-3-yl)methanol are frequently queried in scientific databases. While not classified as hazardous under current guidelines, proper laboratory handling protocols should be followed. The compound's biodegradation profile is under investigation, reflecting the industry's focus on green chemistry principles—a top-searched term in 2024 research publications.

Commercial availability of this compound has increased due to demand from contract research organizations (CROs) and academic institutions. Suppliers often provide technical data sheets detailing storage conditions (typically 2-8°C under inert atmosphere) and solubility profiles (DMSO, ethanol). These specifications are critical for researchers troubleshooting compound solubility issues—a common pain point in drug discovery workflows.

Future research directions for 1314912-56-5 may explore its utility in proteolysis targeting chimeras (PROTACs) and covalent inhibitor design, two rapidly evolving areas in drug development. The compound's balanced lipophilicity (predicted LogP ~0.5) makes it particularly interesting for blood-brain barrier penetration studies—a subject generating numerous PubMed searches this year.

For synthetic chemists, optimization of large-scale preparation methods for this compound remains an active area of investigation. Recent patents describe improved yields through catalytic hydrogenation approaches, addressing common questions about cost-effective synthesis in online chemistry communities. The development of continuous flow processes for such heterocycles is another trending topic in process chemistry circles.

In summary, (6-Aminopyridazin-3-yl)methanol represents an important building block in modern organic synthesis with expanding applications across life sciences. Its combination of synthetic accessibility and structural features continues to drive innovation in rational drug design and agrochemical development, making CAS No. 1314912-56-5 a compound of enduring scientific interest.

• 120854-58-2(3-PYRIDAZINECARBOXYLIC ACID, 6-AMINO-, HYDROCHLORIDE)
• 2060043-43-6((6-Aminopyridazin-3-yl)methanol hydrochloride)
• 1000895-26-0((3-Amino-1H-pyrazol-5-yl)methanol)
• 948571-48-0((3-Amino-1H-pyrazol-5-yl)methanol)
• 59772-58-6(6-Aminopyridazine-3-carboxylic acid)
• 18591-82-7(6-Methylpyridazin-3-amine)
• 1185309-73-2(3-Amino-6-(methyl-d3)-pyridazine)
• 2241872-67-1(6-(methyl-d3)pyridazin-4,5-d2-3-amine)
• 69184-73-2(6-methylpyridazin-3-amine hydrochloride)
• 1222844-85-0(6-Amino-pyridazine-3-carboxylic acid, sodium salt)