• 1. An artificial photosynthetic system for photoaccumulation of two electrons on a fused dipyridophenazine (dppz)–pyridoquinolinone ligand?
  Philipp Traber,Stephan Kupfer,Stefanie Gr?fe,Isabelle Baussanne,Martine Demeunynck,Jean-Marie Mouesca,Serge Gambarelli,Vincent Artero,Murielle Chavarot-Kerlidou Chem. Sci., 2018,9, 4152-4159
• 2. An integrated microfluidic platform for sensitive and rapid detection of biological toxins?
  Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053
• 3. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 4. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
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• 5. An apparatus for testing water by measurement of its electrical conductivity
  Analyst, 1912,37, 538-543

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinoline carboxylic acids

Comprehensive Overview of 7-Chloro-6-fluoro-2-methylquinoline-4-carboxylic acid (CAS No. 1313712-73-0)

7-Chloro-6-fluoro-2-methylquinoline-4-carboxylic acid (CAS No. 1313712-73-0) is a high-value quinoline derivative widely utilized in pharmaceutical and agrochemical research. This compound belongs to the heterocyclic carboxylic acid family, characterized by its unique chloro-fluoro-methyl substitution pattern, which enhances its reactivity and biological activity. Researchers and industries prioritize this chemical due to its role as a key intermediate in synthesizing bioactive molecules, particularly in drug discovery for antimicrobial and anti-inflammatory applications.

In recent years, the demand for fluorinated quinoline compounds like 7-Chloro-6-fluoro-2-methylquinoline-4-carboxylic acid has surged, driven by their potential in addressing antibiotic resistance—a critical global health concern. The compound’s structural versatility allows modifications to improve pharmacokinetic properties, making it a hotspot in medicinal chemistry. Its CAS No. 1313712-73-0 is frequently searched in academic databases, reflecting its relevance in high-throughput screening and targeted therapy development.

From a synthetic perspective, 7-Chloro-6-fluoro-2-methylquinoline-4-carboxylic acid is synthesized via multi-step organic reactions, often involving halogenation and cyclization techniques. Its carboxylic acid group enables further functionalization, such as esterification or amide coupling, to create derivatives with enhanced bioactivity. This adaptability aligns with the growing trend of fragment-based drug design, where small molecules serve as building blocks for larger therapeutics.

Environmental and regulatory considerations also shape the discourse around this compound. As sustainability gains traction, researchers explore green chemistry approaches to synthesize 7-Chloro-6-fluoro-2-methylquinoline-4-carboxylic acid with minimal waste. Questions like "How to optimize the yield of CAS 1313712-73-0?" or "What are the eco-friendly alternatives for its production?" dominate forums, highlighting the intersection of efficiency and environmental responsibility.

Analytical characterization of 7-Chloro-6-fluoro-2-methylquinoline-4-carboxylic acid relies on advanced techniques like HPLC, NMR, and mass spectrometry to ensure purity and structural integrity. These methods address common user queries such as "How to validate the purity of CAS 1313712-73-0?" or "What solvents are compatible with this compound?". Such details are crucial for laboratories aiming to integrate this intermediate into scalable workflows.

Beyond pharmaceuticals, 7-Chloro-6-fluoro-2-methylquinoline-4-carboxylic acid finds niche applications in material science, particularly in designing fluorescent probes and organic electronic materials. Its electron-withdrawing groups contribute to tunable optical properties, a feature leveraged in developing sensors for environmental monitoring. This multidisciplinary utility underscores its importance in both life sciences and industrial innovation.

In summary, 7-Chloro-6-fluoro-2-methylquinoline-4-carboxylic acid (CAS No. 1313712-73-0) exemplifies the convergence of chemical innovation and practical application. Its role in addressing contemporary challenges—from drug resistance to sustainable synthesis—positions it as a compound of enduring scientific and commercial interest. Future research will likely explore its potential in precision medicine and smart materials, further expanding its impact across industries.

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