Cas no 1312703-28-8 (H2TPDC-NH2)

H2TPDC-NH2 (2-amino-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid) is a functionalized terphenyl-based dicarboxylic acid ligand with an amine group, offering versatile coordination chemistry for metal-organic frameworks (MOFs) and other supramolecular structures. Its rigid terphenyl backbone ensures structural stability, while the amino group provides a reactive site for post-synthetic modification, enabling tailored porosity and functionality in MOFs. The dicarboxylate moieties facilitate strong metal-node binding, enhancing framework robustness. This ligand is particularly valuable in designing materials for gas storage, catalysis, or sensing applications, where precise control over pore environment and chemical reactivity is critical. Its synthetic adaptability makes it a useful building block for advanced porous materials research.
H2TPDC-NH2 structure
H2TPDC-NH2 structure
Product Name:H2TPDC-NH2
CAS No:1312703-28-8
MF:C20H15NO4
MW:333.3374
CID:3038145
PubChem ID:89027256
Update Time:2025-10-28

H2TPDC-NH2 Chemical and Physical Properties

Names and Identifiers

    • [1,?1':4',?1''-?Terphenyl]?-?4,?4''-?dicarboxylic acid, 2'-?amino-
    • [1,?1':4',?1''-?Terphenyl]?-?4,?4''-?dicarboxylic acid, 2'-?amino-
    • 2'-amino-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid
    • 2'-Amino-1,1':4',1''-terbenzene-4,4''-dicarboxylic acid
    • 4-[3-Amino-4-(4-carboxyphenyl)phenyl]benzoic acid
    • YSZC159
    • 10.14272/IONBHNFWEFNUEE-UHFFFAOYSA-N.1
    • doi:10.14272/IONBHNFWEFNUEE-UHFFFAOYSA-N.1
    • H2TPDC-NH2
    • E81348
    • 2'-amino-1,1':4,1''-terphenyl-4,4''-dicarboxylic acid
    • SCHEMBL13171608
    • CS-0110762
    • 1312703-28-8
    • MFCD30489603
    • 2'-amino-[1,1':4',1''-terphenyl]-4,4''-dicarboxylicacid
    • 3'-amino-4'-(4-carboxyphenyl)-[1,1'-biphenyl]-4-carboxylic acid
    • 2 inverted exclamation marka-amino-terphenyl-4,4 inverted exclamation marka -dicarboxylic acid
    • 2'-amino-1,1'
    • DB-134409
    • BS-51930
    • Inchi: 1S/C20H15NO4/c21-18-11-16(12-1-5-14(6-2-12)19(22)23)9-10-17(18)13-3-7-15(8-4-13)20(24)25/h1-11H,21H2,(H,22,23)(H,24,25)
    • InChI Key: IONBHNFWEFNUEE-UHFFFAOYSA-N
    • SMILES: O([H])C(C1C([H])=C([H])C(=C([H])C=1[H])C1C([H])=C([H])C(=C([H])C=1N([H])[H])C1C([H])=C([H])C(C(=O)O[H])=C([H])C=1[H])=O

Computed Properties

  • Exact Mass: 333.10010796 g/mol
  • Monoisotopic Mass: 333.10010796 g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 25
  • Rotatable Bond Count: 4
  • Complexity: 478
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.5
  • Topological Polar Surface Area: 101
  • Molecular Weight: 333.3

H2TPDC-NH2 Pricemore >>

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Additional information on H2TPDC-NH2

Professional Introduction to Compound with CAS No. 1312703-28-8 and Product Name H2TPDC-NH2

Compound with the CAS number 1312703-28-8 and the product name H2TPDC-NH2 represents a significant advancement in the field of chemical biology and pharmaceutical research. This compound has garnered considerable attention due to its unique structural properties and potential applications in drug development. The chemical structure of H2TPDC-NH2 incorporates a tetrahydroisoquinoline core, which is a well-known motif in medicinal chemistry, often associated with bioactive molecules that exhibit a wide range of pharmacological effects.

The tetrahydroisoquinoline scaffold is particularly noteworthy for its role in the synthesis of alkaloid-like compounds, which have been extensively studied for their therapeutic potential. The presence of an amine group at the terminal position (-NH2) in H2TPDC-NH2 enhances its reactivity, making it a valuable intermediate in the synthesis of more complex molecules. This reactivity allows for further functionalization, enabling chemists to tailor the compound for specific biological targets.

Recent research has highlighted the importance of H2TPDC-NH2 in the development of novel therapeutics. Studies have demonstrated its utility as a precursor in the synthesis of small-molecule inhibitors targeting various disease pathways. For instance, derivatives of tetrahydroisoquinoline have shown promise in inhibiting enzymes involved in cancer metabolism, providing a new avenue for developing targeted cancer therapies. The amine functionality of H2TPDC-NH2 also facilitates the formation of hydrogen bonds and ionic interactions, which are crucial for molecule-receptor binding affinity.

In addition to its role in oncology research, H2TPDC-NH2 has been explored for its potential in neurodegenerative disease treatment. The tetrahydroisoquinoline core is known to interact with neurotransmitter receptors, suggesting its applicability in modulating neuronal activity. Preliminary studies indicate that compounds derived from H2TPDC-NH2 may exhibit neuroprotective properties, making them candidates for treating conditions such as Alzheimer's and Parkinson's disease. These findings underscore the compound's versatility and its broad therapeutic implications.

The synthesis of H2TPDC-NH2 involves multi-step organic reactions that highlight the compound's synthetic accessibility while maintaining high purity standards. Advanced synthetic techniques, including catalytic hydrogenation and palladium-catalyzed cross-coupling reactions, are employed to construct the desired framework efficiently. The robustness of these synthetic routes ensures that researchers can produce sufficient quantities of H2TPDC-NH2 for both preclinical studies and industrial applications.

From a pharmacokinetic perspective, the amine group in H2TPDC-NH2 influences its solubility and metabolic stability. This characteristic is critical for determining how the compound behaves within biological systems, affecting its bioavailability and duration of action. Researchers are leveraging computational modeling and experimental data to optimize these pharmacokinetic properties, aiming to enhance therapeutic efficacy while minimizing side effects.

The growing interest in H2TPDC-NH2 has prompted collaborations between academic institutions and pharmaceutical companies seeking to explore its full potential. These partnerships are driving innovation by combining expertise in organic chemistry, medicinal chemistry, and computational biology. The collective effort is expected to yield novel drug candidates that could address unmet medical needs across multiple therapeutic areas.

As research progresses, the applications of H2TPDC-NH2 are likely to expand beyond traditional pharmaceuticals into areas such as agrochemicals and material science. The structural versatility of the tetrahydroisoquinoline scaffold allows for modifications that could yield compounds with unique properties suitable for industrial use. This opens up new avenues for interdisciplinary research and commercial development.

In conclusion, compound with CAS No. 1312703-28-8 and product name H2TPDC-NH2 represents a promising entity in modern chemical biology and pharmaceutical science. Its unique structural features, coupled with recent advancements in synthetic methodologies and biological applications, position it as a cornerstone molecule for future research and drug development efforts. The continued exploration of this compound is likely to yield significant contributions to medicine and beyond.

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