• 1. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 2. Alumina grafted SBA-15 sustainable bifunctional catalysts for direct cross-coupling of benzylic alcohols to diarylmethanes?
  Chandran Rajendran,Govindaswamy Satishkumar,Charlotte Lang,Eric M. Gaigneaux Catal. Sci. Technol., 2020,10, 2583-2592
• 3. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 4. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 5. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312

Introduction to (2-Aminothiazol-5-yl)methanol (CAS No. 131184-73-1)

The compound (2-Aminothiazol-5-yl)methanol, with the CAS registry number 131184-73-1, is an intriguing organic molecule that has garnered attention in various fields of chemistry and materials science. This compound belongs to the class of thiazoles, which are five-membered heterocyclic compounds containing sulfur and nitrogen atoms. The presence of the amino group (-NH?) at the 2-position and the hydroxymethyl group (-CH?OH) at the 5-position of the thiazole ring imparts unique chemical properties, making it a versatile building block for further chemical modifications.

The synthesis of (2-Aminothiazol-5-yl)methanol has been explored through various routes, including condensation reactions and substitution reactions. Recent advancements in catalytic methodologies have enabled more efficient and selective syntheses, reducing production costs and minimizing environmental impact. For instance, researchers have employed transition metal catalysts, such as palladium complexes, to facilitate coupling reactions involving this compound. These developments underscore its potential as a key intermediate in the synthesis of more complex molecules.

The chemical properties of (2-Aminothiazol-5-yl)methanol are heavily influenced by its functional groups. The amino group renders the molecule nucleophilic, enabling it to participate in reactions such as alkylation, acylation, and amidation. Meanwhile, the hydroxymethyl group introduces hydrophilicity, which can be advantageous in applications requiring solubility in polar solvents. The thiazole ring itself is known for its aromaticity and stability, contributing to the compound's thermal and chemical resistance.

In terms of applications, (2-Aminothiazol-5-yl)methanol has found utility in several domains. In pharmaceutical chemistry, it serves as a precursor for bioactive compounds with potential therapeutic applications. For example, derivatives of this compound have been investigated for their anti-inflammatory and antioxidant properties. In materials science, it has been used as a building block for the synthesis of advanced polymers and coordination compounds. Its ability to form hydrogen bonds makes it particularly suitable for applications involving molecular recognition and self-assembling systems.

Recent research has focused on exploring the biological activity of (2-Aminothiazol-5-yl)methanol derivatives. Studies have demonstrated that certain analogs exhibit potent inhibitory effects against enzymes involved in inflammatory pathways, suggesting their potential as anti-inflammatory agents. Additionally, investigations into their antioxidant properties have revealed their ability to scavenge free radicals, which could be beneficial in combating oxidative stress-related diseases.

The environmental impact of (2-Aminothiazol-5-yl)methanol is another area of growing interest. Researchers are examining its biodegradability and toxicity profiles to assess its safety for industrial and biomedical applications. Preliminary studies indicate that under specific conditions, the compound can undergo microbial degradation, reducing its persistence in the environment.

In conclusion, (2-Aminothiazol-5-yl)methanol (CAS No. 131184-73-1) is a multifaceted compound with promising applications across diverse fields. Its unique chemical structure, coupled with recent advancements in synthetic methodologies and biological studies, positions it as a valuable tool for future innovations in chemistry and materials science.

• 40283-46-3(2-Aminothiazole-5-carboxylic acid)
• 1185307-07-6(2-Amino-5-(methyl-d3)-thiazole)
• 920337-78-6(5-(methoxymethyl)-1,3-thiazol-2-amine)
• 2891512-12-0(5-(methyl-d3)thiazol-4-d-2-amine)
• 1267174-26-4(2-(dimethylamino)-1,3-thiazol-5-ylmethanol)
• 915866-00-1(5-Thiazolemethanol, 2-amino-4-methyl-)
• 1194551-45-5(5-(ethoxymethyl)-2-Thiazolamine)
• 1640995-62-5((2-Aminothiazol-5-yl)methanol hydrochloride)
• 6593-86-8(5-Methylthiazol-2-amine hydrochloride)
• 7305-71-7(5-methyl-1,3-thiazol-2-amine)