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• 2. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
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• 3. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
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• Solvents and Organic Chemicals Organic Compounds Organohalogen compounds Sulfonyl halides Sulfonyl chlorides

Comprehensive Overview of 1-Ethylcyclopropane-1-sulfonyl chloride (CAS No. 1310730-52-9): Properties, Applications, and Industry Relevance

1-Ethylcyclopropane-1-sulfonyl chloride (CAS No. 1310730-52-9) is a specialized sulfonyl chloride derivative with a unique cyclopropane backbone. This compound has garnered significant attention in recent years due to its versatile reactivity and potential applications in pharmaceutical intermediates, agrochemical synthesis, and material science. The presence of both the ethylcyclopropane moiety and the highly reactive sulfonyl chloride group makes it a valuable building block for designing complex molecular architectures.

In the context of green chemistry trends, researchers are increasingly exploring 1-Ethylcyclopropane-1-sulfonyl chloride as a potential candidate for sustainable synthesis routes. Its molecular structure allows for selective transformations under mild conditions, aligning with the industry's shift toward energy-efficient processes. Recent studies highlight its utility in catalyzed reactions, where it demonstrates exceptional compatibility with transition metal catalysts and organocatalysts.

The compound's physicochemical properties are critical for its applications. With a molecular formula of C₅H₉ClO₂S, it typically appears as a colorless to pale yellow liquid under standard conditions. Its boiling point and solubility profile make it suitable for reactions in both polar aprotic solvents (e.g., DMF, acetonitrile) and non-polar organic media. These characteristics address common search queries like "how to handle sulfonyl chlorides safely" and "best solvents for sulfonylation reactions."

From a pharmaceutical perspective, 1-Ethylcyclopropane-1-sulfonyl chloride serves as a precursor for biologically active sulfonamides. Its cyclopropane ring contributes to conformational rigidity, a feature highly sought after in drug design to enhance target binding affinity. Industry reports suggest its growing use in developing small-molecule inhibitors for enzymes involved in inflammatory pathways and metabolic disorders.

In material science, this compound's sulfonyl chloride group enables surface functionalization of polymers and nanoparticles. Researchers investigating "advanced polymer modification techniques" often explore its reactivity toward amine-terminated substrates, creating sulfonamide-linked hybrid materials. Such applications align with trending topics like "smart coatings" and "functional nanomaterials."

Quality control of 1310730-52-9 involves rigorous analytical methods such as HPLC purity testing and NMR spectroscopy. These protocols ensure batch-to-batch consistency, addressing frequent purchaser concerns about "how to verify sulfonyl chloride purity." Storage recommendations typically emphasize anhydrous conditions and temperature-controlled environments to prevent hydrolysis.

The commercial availability of 1-Ethylcyclopropane-1-sulfonyl chloride has expanded due to demand from contract research organizations (CROs) and custom synthesis providers. Suppliers now offer gram-to-kilogram scale quantities with certificates of analysis, responding to search trends like "bulk sulfonyl chloride suppliers." Regulatory compliance documentation, including REACH registration status, is increasingly requested by buyers navigating global chemical compliance requirements.

Emerging research directions include exploring its photophysical properties for optoelectronic applications and investigating microwave-assisted reactions to improve synthesis efficiency. These developments cater to academic and industrial audiences searching for "innovative uses of sulfonyl chlorides" or "accelerated organic synthesis methods."

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