Cas no 1310693-92-5 (Tubastatin A hydrochloride)

Tubastatin A hydrochloride is a selective and potent inhibitor of histone deacetylase 6 (HDAC6), exhibiting an IC50 value of ~15 nM. It demonstrates high specificity for HDAC6 over other HDAC isoforms, making it a valuable tool for studying HDAC6-mediated cellular processes. The compound has been widely utilized in research to investigate the role of HDAC6 in protein aggregation, neurodegeneration, and cancer biology. Its hydrochloride salt form enhances solubility and stability, ensuring reliable performance in biochemical and cell-based assays. Tubastatin A hydrochloride is particularly useful for probing the therapeutic potential of HDAC6 inhibition in diseases such as multiple myeloma and Alzheimer's.

Tubastatin A hydrochloride structure

Product Name:Tubastatin A hydrochloride

CAS No:1310693-92-5

MF:C₂₀H₂₂ClN₃O₂

MW:371.860583782196

MDL:MFCD20488052

CID:829170

Update Time:2025-05-20

Tubastatin A hydrochloride Chemical and Physical Properties

Names and Identifiers

- Tubastatin A hydrochloride
- Tubastatin A HCl
- N-Hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5 -yl)methyl]benzamide hydrochloride (1:1)
- Tubastatin A Hydroch
- Tubastatin A Hydrochloride (Also See: T897000)
- Tubastatin A Hydrochloride(Also See: T897000)
- TSA HCl
- N-Hydroxy-4-[[2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl]methyl]benzamide Hydrochloride
- N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
- MDL： MFCD20488052
- Inchi： 1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H
- InChI Key： LJTSJTWIMOGKRJ-UHFFFAOYSA-N
- SMILES： Cl.O=C(C1C=CC(=CC=1)CN1C2C=CC=CC=2C2CN(C)CCC1=2)NO

Computed Properties

Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 3
Heavy Atom Count: 26
Rotatable Bond Count: 4

Tubastatin A hydrochloride Security Information

Signal Word：Warning
Hazard Statement： H302-H315-H319-H335
Warning Statement： P261-P305+P351+P338
Storage Condition：<0°C

Tubastatin A hydrochloride Customs Data

HS CODE：29339900

Tubastatin A hydrochloride Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
S e l l e c k ZHONG GUO	S2627-10mM (1mL in DMSO)	Tubastatin A HCl	1310693-92-5	99.30%	10mM (1mL in DMSO)	￥1306.88	2023-09-15
S e l l e c k ZHONG GUO	S2627-10mg	Tubastatin A HCl	1310693-92-5	99.30%	10mg	￥977.38	2023-09-15
S e l l e c k ZHONG GUO	S2627-50mg	Tubastatin A HCl	1310693-92-5	99.30%	50mg	RMB2191.16	2021-07-13
S e l l e c k ZHONG GUO	S2627-100mg	Tubastatin A HCl	1310693-92-5	99.30%	100mg	￥3864.75	2023-09-15
S e l l e c k ZHONG GUO	S2627-200mg	Tubastatin A HCl	1310693-92-5	99.30%	200mg	￥7127.94	2022-04-26
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	T129677-10mg	Tubastatin A hydrochloride	1310693-92-5	≥98%	10mg	￥378.90	2023-08-31
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	T129677-250mg	Tubastatin A HCl	1310693-92-5	≥98%	250mg	￥2,280.00	2021-05-25
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	T129677-50mg	Tubastatin A hydrochloride	1310693-92-5	≥98%	50mg	￥667.90	2023-08-31
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	T129677-5mg	Tubastatin A hydrochloride	1310693-92-5	≥98%	5mg	￥223.90	2023-08-31
DC Chemicals	DC6303-100 mg	Tubastatin A HCl	1310693-92-5	>98%	100mg	$300.0	2022-02-28

Tubastatin A hydrochloride Suppliers

Amadis Chemical Company Limited

Gold Member

Audited Supplier

(CAS:1310693-92-5)Tubastatin A hydrochloride

Order Number:A888595

Stock Status:in Stock

Quantity:100mg/200mg

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 11:25

Price ($):182.0/313.0

Email:[email protected]

Product Official Link

Tubastatin A hydrochloride Related Literature

1. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)

Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
2. Fc microparticles can modulate the physical extent and magnitude of complement activity?

David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
3. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?

Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
4. Emergence of microfluidic wearable technologies

Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
5. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?

Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526

Related Categories

Additional information on Tubastatin A hydrochloride

Comprehensive Overview of Tubastatin A Hydrochloride (CAS No. 1310693-92-5): Mechanism, Applications, and Research Insights

Tubastatin A hydrochloride (CAS No. 1310693-92-5) is a highly selective and potent inhibitor of histone deacetylase 6 (HDAC6), a key enzyme involved in epigenetic regulation and cellular homeostasis. With its molecular formula C₂₀H₂₁N₃O₂·HCl, this compound has garnered significant attention in biomedical research due to its unique specificity for HDAC6 over other HDAC isoforms. Researchers frequently search for terms like "HDAC6 inhibitor", "Tubastatin A solubility", and "Tubastatin A vs. other HDAC inhibitors", reflecting its growing relevance in drug discovery and disease modeling.

The mechanism of action of Tubastatin A hydrochloride centers on its ability to modulate α-tubulin acetylation, a process critical for cytoskeletal stability and intracellular transport. Unlike pan-HDAC inhibitors, Tubastatin A exhibits minimal off-target effects, making it a preferred tool for studying HDAC6-dependent pathways. Recent studies highlight its potential in addressing neurodegenerative diseases, cancer immunotherapy, and inflammatory disorders—topics trending in scientific forums and AI-driven literature searches. Questions such as "Can Tubastatin A cross the blood-brain barrier?" or "Tubastatin A clinical trials 2023" underscore its translational potential.

From a biochemical perspective, Tubastatin A hydrochloride demonstrates an IC₅₀ of ~15 nM for HDAC6, with >1,000-fold selectivity over HDAC1. This precision enables researchers to dissect HDAC6's role in aggresome formation and protein degradation without confounding results from other HDACs. Its application extends to ChIP-seq and proteomics studies, where users often inquire about "Tubastatin A protocol for cell culture" or "optimal dosage for in vivo studies". The compound's stability in aqueous solutions (pH 3–7) and bioavailability further enhance its utility.

Emerging trends link Tubastatin A hydrochloride to autophagy modulation and immune checkpoint regulation, areas dominating recent PubMed citations. Notably, its synergy with PARP inhibitors in oncology models has sparked debates on "combination therapy strategies". The compound's hydrochloride salt form (CAS 1310693-92-5) ensures improved solubility for experimental reproducibility—a detail frequently queried in researchgate discussions.

Quality control parameters for Tubastatin A hydrochloride typically include HPLC purity (>98%), mass spectrometry validation, and endotoxin testing. These metrics address common purchaser concerns like "how to verify Tubastatin A authenticity" or "storage conditions for long-term stability". As the scientific community pivots toward targeted epigenetic therapies, this compound remains at the forefront of translational research, bridging gaps between bench findings and therapeutic innovation.

1310693-92-5 (Tubastatin A hydrochloride) Related Products

Recommended suppliers