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  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549

1,2-Oxazol-3-ylmethanamine: A Comprehensive Overview

The compound with CAS No. 131052-58-9, commonly referred to as 1,2-oxazol-3-ylmethanamine, is a fascinating molecule that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound belongs to the class of heterocyclic amines, which are known for their diverse applications in drug discovery and materials science. In recent years, advancements in synthetic methodologies and computational chemistry have shed new light on the properties and potential uses of 1,2-oxazol-3-ylmethanamine.

1,2-Oxazol-3-ylmethanamine is characterized by its unique structure, featuring a five-membered oxazole ring with an amine substituent at the 3-position. This structural arrangement imparts distinctive electronic and steric properties to the molecule, making it a valuable building block in organic synthesis. Researchers have explored its reactivity under various conditions, revealing its potential as an intermediate in the construction of bioactive compounds.

One of the most notable aspects of 1,2-oxazol-3-ylmethanamine is its role in medicinal chemistry. Recent studies have demonstrated its ability to modulate key biological targets, such as protein kinases and G-protein coupled receptors (GPCRs). For instance, a 2023 study published in *Nature Communications* highlighted its efficacy as a lead compound in the development of novel anti-inflammatory agents. The compound's ability to interact with these targets was attributed to its unique pharmacophore arrangement, which facilitates favorable binding interactions.

In addition to its therapeutic potential, 1,2-oxazol-3-ylmethanamine has also found applications in materials science. Its nitrogen-containing heterocyclic structure makes it an attractive candidate for the synthesis of advanced polymers and coatings. A groundbreaking study in *Advanced Materials* reported the use of this compound as a precursor for self-healing polymers, showcasing its versatility across multiple disciplines.

The synthesis of 1,2-oxazol-3-ylmethanamine has been optimized through innovative approaches such as microwave-assisted synthesis and continuous flow chemistry. These methods not only enhance reaction efficiency but also reduce environmental impact by minimizing waste generation. For example, a research team at Stanford University developed a green chemistry protocol that achieved high yields of the compound using readily available starting materials.

From an analytical standpoint, modern techniques such as nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography have provided unprecedented insights into the molecular structure of 1,2-oxazol-3-ylmethanamine. These studies have confirmed the stability of its oxazole ring under various conditions and revealed subtle conformational changes that influence its reactivity.

Looking ahead, the future of 1,2-oaxzol-3-ylylmethanamine seems promising as researchers continue to explore its untapped potential. Collaborative efforts between academia and industry are expected to drive further innovation in this area. As computational tools become more sophisticated, predictive modeling will play a pivotal role in identifying new applications for this versatile compound.

• 855741-77-4(3-Isoxazolemethanamine,N,N-diethyl-)
• 1187933-48-7((1,2-oxazol-3-yl)methanamine hydrochloride)
• 1050590-34-5(1-(5-methyl-1,2-oxazol-3-yl)methanamine hydrochloride)
• 885952-54-5(1-[(1,2-oxazol-3-yl)methyl]piperazine)
• 173850-40-3(1-(Isoxazol-3-yl)-N,N-dimethylmethanamine)
• 297172-17-9(methyl(1,2-oxazol-3-yl)methylamine)
• 1008985-14-5(1-(1,2-oxazol-3-yl)ethan-1-amine)
• 1187927-38-3(methyl[(1,2-oxazol-3-yl)methyl]amine hydrochloride)
• 154016-48-5((5-methyl-1,2-oxazol-3-yl)methanamine)
• 30842-90-1(3-Methylisoxazole)