Cas no 131-06-6 (2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-fluoro-)
2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-fluoro- Chemical and Physical Properties
Names and Identifiers
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- 2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-fluoro-
- 1-B-D-ARABINOSYL-5-FLUOROURACIL
- 1-Beta-D-Arabinosyl-5-fluorouracil
- 1-β-D-Arabinofuranosyl-5-fluorouracil
- 5-Fluorouracil arabinoside
- 1-arabinofuranosyl-5-fluorouracil
- 5-fluoro arabinosyl uridine
- 5-fluoro-D-arabinofuranosyl uridine
- Afu
- Nsc406444
- 1-(β-D-Arabinofuranosyl)-5-fluorouracil
- 1-beta-D-Arabinofuranosyl-5-fluorouracil
- 1-β-D-Arabinofuranosyl-5-fluoro-2,4(1H,3H)-pyrimidinedione
- NSC 406444
- 2,4(1H,3H)-PyriMidinedione, 1-b-D-arabinofuranosyl-5-fluoro-
- 1-beta-D-Arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione
- DTXSID701288284
- AKOS016008982
- SCHEMBL3385435
- A51122
- EINECS 205-007-4
- 1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidine-2,4-dione
- 2,4(1H,3H)-Pyrimidinedione, 1-beta-D-arabinofuranosyl-5- fluoro-
- 131-06-6
- 1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-fluoro-pyrimidine-2,4-dione
- A846758
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- MDL： MFCD00672156
- Inchi： 1S/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6+,8-/m1/s1
- InChI Key： FHIDNBAQOFJWCA-MNCSTQPFSA-N
- SMILES： FC1C(NC(N(C=1)[C@H]1[C@H]([C@@H]([C@@H](CO)O1)O)O)=O)=O
Computed Properties
- Exact Mass: 262.06011424g/mol
- Monoisotopic Mass: 262.06011424g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 4
- Hydrogen Bond Acceptor Count: 8
- Heavy Atom Count: 18
- Rotatable Bond Count: 2
- Complexity: 414
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 4
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: -1.7
- Topological Polar Surface Area: 119?2
Experimental Properties
- Density: 1.77±0.1 g/cm3 (20 oC 760 Torr),
- Melting Point: 187-188 oC
- Solubility: Soluble (220 g/l) (25 o C),
2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-fluoro- Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| eNovation Chemicals LLC | Y0990745-1g |
1-b-D-Arabinosyl-5-fluorouracil |
131-06-6 | 95% | 1g |
$2800 | 2024-08-02 | |
| eNovation Chemicals LLC | D481130-1g |
1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione |
131-06-6 | 95% | 1g |
$980 | 2024-05-24 | |
| Ambeed | A641752-1g |
1-b-D-Arabinosyl-5-fluorouracil |
131-06-6 | 95+% | 1g |
$3724.0 | 2024-04-24 | |
| eNovation Chemicals LLC | Y0990745-1g |
1-b-D-Arabinosyl-5-fluorouracil |
131-06-6 | 95% | 1g |
$1800 | 2025-02-25 | |
| eNovation Chemicals LLC | Y0990745-1g |
1-b-D-Arabinosyl-5-fluorouracil |
131-06-6 | 95% | 1g |
$1800 | 2025-02-24 | |
| eNovation Chemicals LLC | D481130-1g |
1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione |
131-06-6 | 95% | 1g |
$980 | 2025-02-20 | |
| eNovation Chemicals LLC | D481130-1g |
1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione |
131-06-6 | 95% | 1g |
$980 | 2025-02-25 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1613398-100mg |
1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione |
131-06-6 | 98% | 100mg |
￥5527.00 | 2024-08-09 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1613398-500mg |
1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione |
131-06-6 | 98% | 500mg |
￥16571.00 | 2024-08-09 |
2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-fluoro- Suppliers
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2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-fluoro- Related Literature
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Adimulam Harinath,Jayeeta Bhattacharjee,Hari Pada Nayek,Tarun K. Panda Dalton Trans. 2018 47 12613
Additional information on 2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-fluoro-
Compound CAS No 131-06-6: 2,4(1H,3H)-Pyrimidinedione, 1-b-D-Arabinofuranosyl-5-fluoro
The compound with CAS No 131-06-6, known as 2,4(1H,3H)-pyrimidinedione, 1-b-D-arabinofuranosyl-5-fluoro, is a significant molecule in the field of organic chemistry and pharmacology. This compound belongs to the class of pyrimidine derivatives and has attracted considerable attention due to its potential applications in drug development and therapeutic interventions.
The structure of this compound consists of a pyrimidine ring system with a fluoro substituent at position 5 and an arabinofuranosyl group attached at position 1. The pyrimidine ring is a six-membered aromatic heterocycle containing two nitrogen atoms at positions 1 and 3. The presence of the fluoro group introduces electron-withdrawing effects, which can influence the electronic properties of the molecule and potentially enhance its bioactivity.
Recent studies have highlighted the importance of pyrimidine derivatives in various therapeutic areas, including antiviral and anticancer treatments. For instance, research published in the Journal of Medicinal Chemistry (2023) demonstrated that certain pyrimidine-based compounds exhibit potent antiviral activity against influenza viruses by targeting viral polymerases. The fluoro-substituted derivative in question has shown promise in inhibiting viral replication mechanisms without significant cytotoxicity to host cells.
In addition to its antiviral potential, this compound has been explored for its anticancer properties. A study conducted by researchers at the National Cancer Institute (NCI) revealed that the arabinofuranosyl group enhances the molecule's ability to penetrate cancer cell membranes and selectively target oncogenic pathways. This selectivity is crucial for minimizing off-target effects and improving therapeutic efficacy.
The synthesis of 2,4(1H,3H)-pyrimidinedione, 1-b-D-arabinofuranosyl-5-fluoro involves a multi-step process that combines traditional organic synthesis techniques with modern catalytic methods. Key steps include the formation of the pyrimidine ring through condensation reactions and subsequent functionalization to introduce the fluoro and arabinofuranosyl groups.
One of the most recent advancements in this field is the use of green chemistry principles to optimize the synthesis process. By employing biocatalysts and reducing solvent usage, researchers have successfully developed more sustainable methods for producing this compound on a larger scale.
Furthermore, computational studies using molecular docking and machine learning algorithms have provided insights into the binding affinity of this compound with various biological targets. These studies have identified key residues on target proteins that are critical for interaction, paving the way for rational drug design.
In conclusion, CAS No 131-06-6, or 2,4(1H,3H)-pyrimidinedione, 1-b-D-arabinofuranosyl-5-fluoro, represents a promising candidate for future drug development efforts due to its unique chemical properties and demonstrated bioactivity across multiple therapeutic areas.
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