• 1. Ni and Cu-catalyzed one pot synthesis of unsymmetrical 1,3-di(hetero)aryl-1H-indazoles from hydrazine, o-chloro (hetero)benzophenones, and (hetero)aryl bromides
  Carson Wiethan,Christopher M. Lavoie,Andrey Borzenko,Jillian S. K. Clark,Helio G. Bonacorso,Mark Stradiotto Org. Biomol. Chem. 2017 15 5062
• 2. Rhodium-catalyzed oxidative annulation of 1H-indazoles with alkynes for the synthesis of indazolo[3,2-a]isoquinolines via C–H bond functionalization
  Jian Huang,Yang Fu,Zhihong Deng,Wei Chen,Zhibin Song,Yiyuan Peng Org. Biomol. Chem. 2020 18 9863
• 3. Syntheses, rearrangements, and structural analyses of unsaturated nitrogen donor ligands derived from diphenyldiazomethane and the chiral rhenium Lewis acid [(η5-C5H5)Re(NO)(PPh3)]+
  Alexander L. Estrada,Taveechai Wititsuwannakul,Klemenz Kromm,Frank Hampel,Michael B. Hall,John A. Gladysz Dalton Trans. 2022 51 7305
• 4. Syntheses, rearrangements, and structural analyses of unsaturated nitrogen donor ligands derived from diphenyldiazomethane and the chiral rhenium Lewis acid [(η5-C5H5)Re(NO)(PPh3)]+
  Alexander L. Estrada,Taveechai Wititsuwannakul,Klemenz Kromm,Frank Hampel,Michael B. Hall,John A. Gladysz Dalton Trans. 2022 51 7305
• 5. Ultrasound-assisted high-yield multicomponent synthesis of triazolo[1,2-a]indazole-triones using silica-coated ZnO nanoparticles as a heterogeneous catalyst
  Divya Verma,Vikash Sharma,Gunadhor Singh Okram,Shubha Jain Green Chem. 2017 19 5885

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Phenylpyrazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles Phenylpyrazoles

Recent Advances in the Study of 3-Phenyl-1H-indazole (CAS: 13097-01-3) and Its Applications in Chemical Biology and Medicine

3-Phenyl-1H-indazole (CAS: 13097-01-3) is a heterocyclic compound that has garnered significant attention in recent years due to its potential applications in chemical biology and medicinal chemistry. This compound, characterized by its indazole core structure substituted with a phenyl group at the 3-position, has been the subject of numerous studies aimed at exploring its biological activities, synthetic routes, and therapeutic potential. The versatility of 3-Phenyl-1H-indazole as a scaffold for drug development and its role in modulating various biological pathways make it a promising candidate for further investigation.

Recent research has focused on elucidating the molecular mechanisms underlying the biological activities of 3-Phenyl-1H-indazole. Studies have demonstrated its ability to interact with key protein targets, including kinases, receptors, and enzymes, which are often implicated in disease processes. For instance, a 2023 study published in the Journal of Medicinal Chemistry reported that derivatives of 3-Phenyl-1H-indazole exhibit potent inhibitory effects against certain cancer-related kinases, suggesting their potential as anticancer agents. The study highlighted the compound's ability to induce apoptosis in cancer cells while sparing normal cells, a desirable property for therapeutic applications.

In addition to its anticancer properties, 3-Phenyl-1H-indazole has also been investigated for its anti-inflammatory and antimicrobial activities. A recent study in Bioorganic & Medicinal Chemistry Letters demonstrated that specific derivatives of this compound could effectively inhibit the production of pro-inflammatory cytokines, making them potential candidates for the treatment of inflammatory diseases. Furthermore, the antimicrobial activity of 3-Phenyl-1H-indazole derivatives against drug-resistant bacterial strains has been explored, with promising results indicating their potential as novel antibiotics.

The synthesis and structural modification of 3-Phenyl-1H-indazole have also been areas of active research. Advances in synthetic methodologies have enabled the efficient production of diverse derivatives with enhanced biological activities and improved pharmacokinetic properties. For example, a 2022 study in Organic Letters described a novel catalytic approach for the regioselective functionalization of the indazole ring, allowing for the rapid generation of structurally diverse analogs. These synthetic innovations are crucial for structure-activity relationship (SAR) studies and the optimization of lead compounds.

Looking ahead, the potential applications of 3-Phenyl-1H-indazole in drug discovery and development are vast. Ongoing research is exploring its use in targeted therapies, combination treatments, and as a probe for studying biological pathways. The compound's unique chemical properties and broad biological activities position it as a valuable tool for advancing our understanding of disease mechanisms and developing new therapeutic interventions. Future studies will likely focus on further optimizing its derivatives, elucidating its mode of action, and translating preclinical findings into clinical applications.

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• 395099-05-5(3-Phenyl-1H-indazol-5-amine)
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