Cas no 130964-39-5 (H-89 dihydrochloride)

H-89 dihydrochloride is a potent and selective inhibitor of protein kinase A (PKA), exhibiting an IC50 value of approximately 48 nM. This cell-permeable compound is widely utilized in biochemical and pharmacological research to study PKA-mediated signaling pathways. Its high selectivity over other kinases, such as PKC and CaMKII, makes it a valuable tool for elucidating the role of PKA in cellular processes. H-89 dihydrochloride is soluble in aqueous buffers and DMSO, facilitating its use in in vitro and cell-based assays. The compound is supplied as a stable hydrochloride salt, ensuring consistent performance in experimental applications. Researchers rely on its well-characterized inhibitory properties for precise modulation of PKA activity.

H-89 dihydrochloride structure

Product Name:H-89 dihydrochloride

CAS No:130964-39-5

MF:C₂₀H₂₄BrCl₂N₃O₃S

MW:537.297861099243

MDL:MFCD00214120

CID:133544

PubChem ID:5702541

Update Time:2025-06-06

H-89 dihydrochloride Chemical and Physical Properties

Names and Identifiers

- 5-Isoquinolinesulfonamide,N-[2-[[3-(4-bromophenyl)-2-propen-1-yl]amino]ethyl]-, hydrochloride (1:2)
- N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline Sulfonamide Dihydrochloride
- H-89 dihydrochloride hydrate
- H 89 2HCl
- 5-Isoquinolinesulfonamide,N-[2-[[3-(4-bromophenyl)-2-propen-1-yl]amino]ethyl]-, hydrochloride ...
- H 89 dihydrochloride
- H-89, Dihydrochloride
- Protein kinase inhibitor H-89 dihydrochloride
- H-89 hydrate dihydrochloride
- (E)-N-(2-(4-bromocinnamylamino)ethyl)isoquinoline-5-sulfonamide dihydrochloride
- (E)-N-(2-((3-(4-bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide dihydrochloride
- N-[2-[[3-(4-BroMophenyl)-2-propen-1-yl]aMino]ethyl]-5-isoquinolinesulfonaMide Hydrochloride
- 5-IsoquinolinesulfonaMide, N-[2-[[3-(4-broMophenyl)-2-propenyl]aMino]ethyl]-, dihydrochloride
- N-[2-[[3-(4-Bromophenyl)-2-Propen-1-Yl]Amino]Ethyl]-5-Isoquinolinesulfonamide Hydrochloride (1:2)
- H-89 Dihydrochloride Hydrate,N-[2-(P-Bromocinnamylamino)Et
- H-89 dihydrochloride
- N-(2-((3-(4-Bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide dihydrochloride
- AKOS015908937
- NCGC00093630-01
- CS-3387
- CHEBI:131488
- N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamidedihydrochloride
- H-89 (dihydrochloride)
- CCG-206850
- B 1427
- s1582
- AS-59346
- 130964-39-5
- H-89 2HCL
- C20H20BrN3O2S.2HCl
- SR-01000075706
- H-89.2HCl
- H-89 hydrochloride
- EU-0100140
- HY-15979A
- N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]-5-isoqu inolinesulfonamide dihydrochloride
- N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide hydrochloride
- H-89 2HCl?
- SR-01000075706-1
- GELOGQJVGPIKAM-WTVBWJGASA-N
- N-(2-{[3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide dihydrochloride
- N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrobromide
- H-89.Dihydrochloride
- BCP15626
- N-(2-((3-(4-Bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamidedihydrochloride
- CHEMBL1315166
- SCHEMBL1048974
- N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide Hydrochloride; H-89 Dihydrochloride;
- H-89 Chloride
- D94893
- J-005475
- SW219404-1
- N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide 2HCl
- 5-[(2-{[3-(4-bromophenyl)prop-2-en-1-yl]azaniumyl}ethyl)sulfamoyl]isoquinolin-2-ium dichloride
- SCHEMBL1048972
- HMS3229M18
- N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide;dihydrochloride
- MFCD00214120
- F14780
- HB0314
- MDL： MFCD00214120
- Inchi： InChI=1S/C20H20BrN3O2S.2ClH/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;/h1-10,12,15,22,24H,11,13-14H2;2*1H/b3-2+;;
- InChI Key： GELOGQJVGPIKAM-WTVBWJGASA-N
- SMILES： O=S(C1=CC=CC2=C1C=CN=C2)(NCCNC/C=C/C3=CC=C(Br)C=C3)=O.Cl.Cl

Computed Properties

Exact Mass: 535.01000
Monoisotopic Mass: 445.046
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 5
Heavy Atom Count: 29
Rotatable Bond Count: 8
Complexity: 570
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 1
Undefined Bond Stereocenter Count: 0
Topological Polar Surface Area: 79.5A^2

Experimental Properties

Color/Form: No data available
Density: 1.436
Melting Point: 195-200°C
Boiling Point: 639.7 639.7 oC at 760 mmHg at 760 mmHg
Flash Point: 340.7 639.7 oC at 760 mmHg
Solubility: H2O: ≥10mg/mL
PSA: 88.70000
LogP: 6.98090
Solubility: H2O: ≥10mg/mL
Vapor Pressure: No data available

H-89 dihydrochloride Security Information

Signal Word：Warning
Hazard Statement： H302-H315-H319-H335
Warning Statement： P261-P305+P351+P338
Safety Instruction： 22-24/25
Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month

H-89 dihydrochloride Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.	H832893-50mg	H-89 dihydrochloride hydrate	130964-39-5	≥99%	50mg	￥1,238.30	2022-01-11
WU HAN AN JIE KAI Biomedical Technology Co., Ltd.	ajci4390-10mg	H 89 2HCl	130964-39-5	98%	10mg	￥516.00	2023-09-10
WU HAN AN JIE KAI Biomedical Technology Co., Ltd.	ajci4390-50mg	H 89 2HCl	130964-39-5	98%	50mg	￥1716.00	2023-09-10
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ChemScence	CS-3387-10mg	H-89 dihydrochloride	130964-39-5	99.34%	10mg	$67.0	2022-04-28
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ChemScence	CS-3387-100mg	H-89 dihydrochloride	130964-39-5	99.34%	100mg	$479.0	2022-04-28
ChemScence	CS-3387-200mg	H-89 dihydrochloride	130964-39-5	99.34%	200mg	$768.0	2022-04-28
ChemScence	CS-3387-500mg	H-89 dihydrochloride	130964-39-5	99.34%	500mg	$1500.0	2022-04-28
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.	H23250-50mg	H 89 Dihydrochloride	130964-39-5	98%	50mg	￥2122.0	2023-09-07

H-89 dihydrochloride Suppliers

Amadis Chemical Company Limited

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Audited Supplier

(CAS:130964-39-5)H-89 dihydrochloride

Order Number:A909083

Stock Status:in Stock

Quantity:250mg/1g

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 12:33

Price ($):230.0/691.0

Email:[email protected]

Product Official Link

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