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  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 2. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 3. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alkyl aryl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Alkyl aryl ethers

Comprehensive Overview of 3-(Benzyloxy)-5-bromopyridine (CAS No. 130722-95-1): Properties, Applications, and Industry Insights

3-(Benzyloxy)-5-bromopyridine (CAS No. 130722-95-1) is a specialized organic compound widely utilized in pharmaceutical and agrochemical research. This brominated pyridine derivative features a benzyloxy substituent at the 3-position, making it a valuable intermediate for synthesizing complex molecules. Its molecular formula, C₁₂H₁₀BrNO, and molecular weight of 264.12 g/mol underscore its role in precision chemical reactions. Researchers frequently search for "3-(Benzyloxy)-5-bromopyridine synthesis" or "CAS 130722-95-1 applications," reflecting its relevance in drug discovery and material science.

The compound's unique structure enables diverse functionalization, particularly in cross-coupling reactions like Suzuki-Miyaura or Buchwald-Hartwig animations. Recent trends highlight its use in developing kinase inhibitors and 5-bromopyridine derivatives for oncology research. With the rise of AI-driven drug design, queries such as "3-(Benzyloxy)-5-bromopyridine computational chemistry" have surged, emphasizing its role in virtual screening workflows. The benzyl-protected hydroxyl group also offers stability during multi-step syntheses, a feature often explored in "protective group strategies for pyridines."

From a regulatory perspective, CAS 130722-95-1 complies with standard laboratory safety protocols without classification as hazardous under GHS. Its storage typically requires protection from light and moisture at room temperature. Industry discussions frequently address "scaling up 3-(Benzyloxy)-5-bromopyridine production," particularly for contract manufacturing organizations (CMOs) supplying pharmaceutical innovators. Analytical methods like HPLC (High-Performance Liquid Chromatography) and NMR (Nuclear Magnetic Resonance) are routinely employed for quality control, as evidenced by searches for "130722-95-1 purity analysis."

Environmental considerations are increasingly shaping compound usage. 3-(Benzyloxy)-5-bromopyridine demonstrates moderate biodegradability in OECD 301 tests, prompting research into greener synthetic routes. This aligns with the "sustainable bromopyridine chemistry" trend, where scientists explore catalytic bromination methods to reduce waste. The compound's electron-deficient pyridine ring also makes it a candidate for organic electronics, connecting to searches about "pyridine-based semiconductors."

Market intelligence indicates growing demand for CAS 130722-95-1 in Asia-Pacific biotech hubs, driven by increased outsourcing of preclinical research. Suppliers often highlight its compatibility with automated synthesis platforms, responding to queries about "high-throughput pyridine derivatives." Patent analysis reveals over 20 medicinal chemistry applications since 2020, particularly in antiviral and CNS drug candidates. These developments position 3-(Benzyloxy)-5-bromopyridine as a compound bridging traditional heterocyclic chemistry with modern therapeutic innovation.

For researchers handling this material, proper personal protective equipment (PPE) including nitrile gloves and safety goggles is recommended. While not classified as dangerous goods, its powder form warrants attention to dust control measures. The scientific community continues to investigate "3-(Benzyloxy)-5-bromopyridine crystal structure" to optimize its use in co-crystallization studies, a technique gaining traction in solubility enhancement strategies for poorly soluble APIs (Active Pharmaceutical Ingredients).

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