• 1. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
• 2. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 3. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 4. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 5. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Haloquinolines

Comprehensive Overview of 6-Bromoquinoline-8-carbaldehyde (CAS No. 1306606-90-5): Properties, Applications, and Market Trends

6-Bromoquinoline-8-carbaldehyde (CAS No. 1306606-90-5) is a high-value heterocyclic aldehyde widely utilized in pharmaceutical and material science research. This compound belongs to the quinoline derivatives family, characterized by a bromine substituent at the 6-position and an aldehyde functional group at the 8-position. Its molecular formula is C₁₀H₆BrNO, with a molar mass of 236.07 g/mol. The unique electronic properties of the quinoline core, combined with the reactivity of the aldehyde group, make it a versatile building block for organic synthesis and drug discovery.

Recent studies highlight the growing demand for 6-Bromoquinoline-8-carbaldehyde in medicinal chemistry, particularly in the development of kinase inhibitors and antimicrobial agents. Researchers are actively exploring its potential in cancer therapeutics, as quinoline-based compounds exhibit promising anti-proliferative activity. The compound’s crystallographic data and HPLC purity (typically ≥95%) are critical parameters for reproducibility in academic and industrial labs. With the rise of AI-driven drug design, this molecule has gained attention in virtual screening libraries due to its structural diversity.

From a commercial perspective, 6-Bromoquinoline-8-carbaldehyde is supplied by leading chemical manufacturers under stringent GMP standards. Its pricing varies based on batch size and custom synthesis requirements. Analytical techniques such as NMR spectroscopy (1H and 13C), mass spectrometry, and FT-IR are employed for quality validation. Environmental considerations include its biodegradability profile, which aligns with the green chemistry movement—a trending topic in 2024.

In material science, this compound serves as a precursor for luminescent materials and organic semiconductors. Its photophysical properties are being investigated for OLED applications, responding to the global push for energy-efficient displays. FAQs from researchers often focus on its solubility (DMSO, ethanol) and storage conditions (2–8°C under inert atmosphere), which are crucial for experimental success.

The synthesis of 6-Bromoquinoline-8-carbaldehyde typically involves Vilsmeier-Haack formylation of 6-bromoquinoline, followed by oxidation. Patent literature reveals its inclusion in innovative drug formulations, with recent filings emphasizing combination therapies for metabolic disorders. Regulatory databases confirm its non-hazardous status under standard handling protocols, though PPE (gloves, goggles) is recommended during use.

Emerging trends in high-throughput screening (HTS) and combinatorial chemistry have amplified its relevance. A 2023 market report projected a 6.8% CAGR for quinoline intermediates, driven by R&D investments in Asia-Pacific regions. For researchers optimizing structure-activity relationships (SAR), this compound’s regioselectivity offers strategic advantages in scaffold hopping strategies.

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