Cas no 1303972-97-5 (tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate)

Tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate is a fluorinated piperidine derivative commonly employed as a versatile intermediate in organic synthesis and pharmaceutical research. The tert-butyloxycarbonyl (Boc) protecting group enhances its stability and facilitates selective deprotection under mild acidic conditions. The hydroxymethyl and fluorine substituents provide reactive handles for further functionalization, making it valuable for constructing complex molecules, particularly in medicinal chemistry. Its well-defined structure and high purity ensure reproducibility in synthetic applications. The compound’s compatibility with a range of reaction conditions underscores its utility in the development of bioactive compounds, including potential drug candidates.
tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate structure
1303972-97-5 structure
Product Name:tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate
CAS No:1303972-97-5
MF:C11H20FNO3
MW:233.279807090759
MDL:MFCD18909817
CID:1091564
PubChem ID:72698307
Update Time:2025-06-22

tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate Chemical and Physical Properties

Names and Identifiers

    • tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate
    • tert-Butyl 4-fluoro-3-(hydroxymethyl)-piperidine-1-carboxylate
    • 1303972-97-5
    • (Trans)-tert-butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate
    • tert-Butyl4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate
    • tert-butyl cis-4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate
    • MFCD18909817
    • CS-W001389
    • AM807603
    • AS-54547
    • 1-Piperidinecarboxylic acid, 4-fluoro-3-(hydroxymethyl)-, 1,1-dimethylethyl ester
    • t-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate
    • 1903828-50-1
    • s11806
    • AKOS022178176
    • 1-Boc-4-fluoropiperidine-3-methanol
    • MDL： MFCD18909817
    • Inchi： 1S/C11H20FNO3/c1-11(2,3)16-10(15)13-5-4-9(12)8(6-13)7-14/h8-9,14H,4-7H2,1-3H3
    • InChI Key： JOKNUZASZUDOEI-UHFFFAOYSA-N
    • SMILES： FC1CCN(C(=O)OC(C)(C)C)CC1CO

Computed Properties

  • Exact Mass: 233.14272166g/mol
  • Monoisotopic Mass: 233.14272166g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 4
  • Complexity: 252
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 2
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.2
  • Topological Polar Surface Area: 49.8?2

Experimental Properties

  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 316.2±27.0 °C at 760 mmHg
  • Flash Point: 145.0±23.7 °C
  • Vapor Pressure: 0.0±1.5 mmHg at 25°C

tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate Security Information

tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate Pricemore >>

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tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate Related Literature

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Additional information on tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate

Comprehensive Overview of tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate (CAS No. 1303972-97-5)

The compound tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate (CAS No. 1303972-97-5) is a fluorinated piperidine derivative with significant applications in pharmaceutical and organic synthesis. Its unique structural features, including the fluoro and hydroxymethyl substituents, make it a versatile intermediate for drug discovery and fine chemical production. Researchers and industry professionals frequently search for this compound due to its relevance in modern medicinal chemistry, particularly in the development of bioactive molecules targeting neurological and metabolic disorders.

In recent years, the demand for fluorinated compounds like tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate has surged, driven by their enhanced metabolic stability and bioavailability. This aligns with the growing interest in fluorine-containing pharmaceuticals, a trending topic in drug development. The compound’s CAS No. 1303972-97-5 is often queried in scientific databases, reflecting its importance in high-value research. Its synthesis typically involves multi-step organic reactions, including protection-deprotection strategies and selective fluorination, which are critical for achieving high purity and yield.

Another key aspect of tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate is its role in peptide mimetics and small molecule inhibitors. These applications are highly sought after in the context of drug design and structure-activity relationship (SAR) studies. The compound’s hydroxymethyl group offers a handle for further functionalization, enabling the creation of diverse derivatives with tailored properties. This flexibility is particularly valuable in optimizing pharmacokinetic profiles, a recurring theme in pharmaceutical R&D.

From an industrial perspective, scalability and cost-effectiveness are critical considerations for CAS No. 1303972-97-5. Manufacturers and suppliers often highlight its compatibility with green chemistry principles, such as reduced solvent usage and catalytic processes. This resonates with the broader shift toward sustainable synthesis, a hot topic in chemical manufacturing. Additionally, the compound’s stability under standard storage conditions makes it a practical choice for laboratory and production settings.

In summary, tert-Butyl 4-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate (CAS No. 1303972-97-5) exemplifies the intersection of innovation and utility in modern chemistry. Its applications span from medicinal chemistry to material science, addressing both academic and industrial needs. As research continues to explore its potential, this compound remains a focal point for advancements in fluorine chemistry and drug development.

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