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Comprehensive Guide to 2-(4-Fluorobenzenesulfonamido)acetic Acid (CAS No. 13029-71-5)

2-(4-Fluorobenzenesulfonamido)acetic acid (CAS No. 13029-71-5) is a specialized sulfonamide derivative with a wide range of applications in pharmaceutical and chemical research. This compound, characterized by its fluorinated aromatic ring and acetic acid moiety, has gained significant attention due to its potential in drug development and material science. In this article, we will explore its properties, synthesis, applications, and market trends, while addressing common queries from researchers and industry professionals.

The molecular structure of 2-(4-fluorobenzenesulfonamido)acetic acid features a 4-fluorophenyl group attached to a sulfonamide linkage, which is further connected to an acetic acid functional group. This unique arrangement contributes to its bioactivity and chemical versatility, making it valuable for designing enzyme inhibitors and bioactive molecules. Recent studies highlight its role in targeting carbonic anhydrase isoforms, a hot topic in cancer and glaucoma research.

In pharmaceutical applications, CAS 13029-71-5 serves as a key intermediate for synthesizing sulfonamide-based drugs. Its fluorine substitution enhances metabolic stability—a critical factor in drug design, as evidenced by its mention in recent AI-driven drug discovery publications. Researchers frequently search for "fluorinated sulfonamide derivatives" and "sulfonamide acetic acid applications," reflecting growing interest in this chemical space.

The synthesis of 2-(4-fluorobenzenesulfonamido)acetic acid typically involves the reaction between 4-fluorobenzenesulfonyl chloride and glycine derivatives, followed by purification. This process aligns with green chemistry principles—another trending topic—as newer methods focus on solvent-free conditions and catalytic optimization. Analytical techniques like HPLC and NMR are essential for quality control, addressing common quality assurance questions in the supply chain.

Beyond pharmaceuticals, this compound shows promise in agrochemical research, particularly in developing herbicide safeners. Its sulfonamide group interacts with plant enzymes, a mechanism explored in sustainable agriculture studies. Industry reports suggest rising demand for fluorine-containing agrochemicals, positioning 13029-71-5 as a compound to watch.

From a commercial perspective, 2-(4-fluorobenzenesulfonamido)acetic acid suppliers emphasize high-purity grades (>98%) for research applications. Market analysis reveals increased procurement for medicinal chemistry libraries, driven by pharmaceutical outsourcing trends. SEO data shows frequent searches for "buy 4-fluorobenzenesulfonamido acetic acid" and "CAS 13029-71-5 suppliers," indicating strong commercial interest.

Storage and handling recommendations for CAS 13029-71-5 include protection from moisture and storage at room temperature—details often requested in technical documentation. Safety data sheets highlight standard laboratory precautions, avoiding classification as hazardous under normal conditions, which facilitates global logistics.

Innovation opportunities surround this molecule, particularly in bioconjugation chemistry and proteolysis-targeting chimeras (PROTACs)—two cutting-edge areas in drug development. Its carboxylic acid group enables diverse derivatization, a feature exploited in recent covalent inhibitor designs published in top chemistry journals.

For researchers investigating structure-activity relationships (SAR), 2-(4-fluorobenzenesulfonamido)acetic acid offers a versatile scaffold. Computational chemistry studies using molecular docking frequently incorporate this structure to explore protein-ligand interactions, addressing common queries about sulfonamide binding motifs.

In conclusion, 2-(4-fluorobenzenesulfonamido)acetic acid (CAS No. 13029-71-5) represents an important building block in modern chemistry. Its applications span from drug discovery to agricultural science, supported by ongoing research into fluorinated compounds. As the pharmaceutical industry continues to value sulfonamide chemistry, this compound maintains relevance in both academic and industrial settings.

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