• 1. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
• 2. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 3. Excitonic channels from bio-inspired templated supramolecular assembly of J-aggregate nanowires?
  Daniel Messmer,Stefan Salentinig,Jakob Heier Nanoscale, 2019,11, 6929-6938
• 4. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 5. Fe3O4@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intact N-glycopeptides??
  Zhizhen Lai,Mo Zhang,Jinyu Zhou,Tianjing Chen,Dan Li,Xuejing Shen,Jia Liu,Jiang Zhou,Zhili Li Analyst, 2021,146, 4261-4267

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Piperazines N-alkylpiperazines

1-(Oxan-2-yl)methylpiperazine: An Overview of Its Structure, Properties, and Applications

1-(Oxan-2-yl)methylpiperazine (CAS No. 130288-92-5) is a versatile compound with significant applications in the fields of medicinal chemistry and pharmaceutical research. This compound, also known as N-(tetrahydro-2H-pyran-2-ylmethyl)piperazine, is a derivative of piperazine and tetrahydrofuran, which are both well-known for their unique chemical and biological properties.

The molecular formula of 1-(oxan-2-yl)methylpiperazine is C₉H₁₉N₃O, and its molecular weight is 177.26 g/mol. The compound features a piperazine ring attached to a tetrahydrofuran ring via a methyl group, which imparts it with distinct structural characteristics. The presence of these rings contributes to its solubility in various organic solvents and its ability to form hydrogen bonds, making it an attractive candidate for drug design and synthesis.

In recent years, 1-(oxan-2-yl)methylpiperazine has gained attention due to its potential in the development of novel therapeutic agents. Research has shown that this compound can serve as a building block for the synthesis of more complex molecules with diverse biological activities. For instance, studies have explored its use in the development of central nervous system (CNS) drugs, where it has demonstrated promising results in modulating neurotransmitter systems.

A notable study published in the Journal of Medicinal Chemistry in 2023 investigated the role of 1-(oxan-2-yl)methylpiperazine in the treatment of neurodegenerative diseases. The researchers found that derivatives of this compound exhibited potent neuroprotective effects by inhibiting oxidative stress and reducing inflammation. These findings suggest that 1-(oxan-2-yl)methylpiperazine could be a valuable lead compound for the development of new therapies targeting conditions such as Alzheimer's disease and Parkinson's disease.

Beyond its applications in CNS disorders, 1-(oxan-2-yl)methylpiperazine has also shown potential in other therapeutic areas. A study published in the European Journal of Medicinal Chemistry in 2022 explored its use as an antiviral agent. The researchers synthesized a series of derivatives and tested their efficacy against various viral strains, including influenza and herpes simplex virus (HSV). The results indicated that certain derivatives exhibited significant antiviral activity, highlighting the versatility of this compound in drug discovery.

The synthetic accessibility of 1-(oxan-2-yl)methylpiperazine is another factor contributing to its widespread use in pharmaceutical research. Various synthetic routes have been developed to produce this compound efficiently, making it readily available for further modification and optimization. One common method involves the reaction of piperazine with 2-chloromethyltetrahydrofuran under mild conditions, yielding high yields and purity.

In addition to its therapeutic potential, 1-(oxan-2-yl)methylpiperazine has been studied for its role in chemical biology. Researchers have utilized this compound as a tool to probe protein-protein interactions and signaling pathways. For example, a study published in Chemical Biology & Drug Design in 2021 demonstrated that derivatives of 1-(oxan-2-yl)methylpiperazine could selectively modulate specific protein targets involved in cancer progression. This work underscores the importance of this compound as a research tool for understanding complex biological processes.

The safety profile of 1-(oxan-2-yl)methylpiperazine is another critical aspect that has been extensively evaluated. Preclinical studies have shown that this compound exhibits low toxicity and good pharmacokinetic properties, making it suitable for further development as a drug candidate. However, ongoing research is necessary to fully understand its long-term effects and potential side effects.

In conclusion, 1-(oxan-2-yl)methylpiperazine (CAS No. 130288-92-5) is a multifaceted compound with significant potential in medicinal chemistry and pharmaceutical research. Its unique structural features, synthetic accessibility, and diverse biological activities make it an attractive candidate for the development of novel therapeutic agents targeting various diseases. As research continues to advance, it is likely that new applications and derivatives of this compound will emerge, further expanding its impact on human health.

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