• 1. Semi-rational hinge engineering: modulating the conformational transformation of glutamate dehydrogenase for enhanced reductive amination activity towards non-natural substrates
  Xinjian Yin,Yayun Liu,Lijun Meng,Haisheng Zhou,Jianping Wu,Lirong Yang Catal. Sci. Technol. 2020 10 3376
• 2. Dioxolanones as synthetic intermediates. Part 1. Synthesis of α-keto acids, α-keto aldehydes, and α-ketols
  Robert Ramage,Gareth J. Griffiths,Fiona E. Shutt,John N. A. Sweeney J. Chem. Soc. Perkin Trans. 1 1984 1531

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Keto acids and derivatives Medium-chain keto acids and derivatives

Comprehensive Guide to 2-Oxohexanoic Acid Sodium Salt (CAS No. 13022-85-0): Properties, Applications, and Industry Insights

2-Oxohexanoic Acid Sodium Salt (CAS No. 13022-85-0), also known as Sodium 2-Oxohexanoate, is a versatile organic compound with growing relevance in biochemical research, pharmaceuticals, and specialty chemicals. This sodium salt derivative of 2-Oxohexanoic Acid offers unique reactivity due to its carbonyl and carboxylate functional groups, making it valuable for synthetic pathways and metabolic studies. In this article, we explore its molecular characteristics, industrial applications, and answers to frequently searched questions about its stability, solubility, and alternatives.

The compound’s structure features a six-carbon backbone with a ketone group at the second position and a sodium-stabilized carboxylate terminus. This configuration enhances its water solubility (solubility in aqueous solutions is a top-searched query), facilitating its use in buffered systems and enzymatic reactions. Researchers often inquire about its pH stability—it remains stable under neutral to slightly alkaline conditions (pH 7–9), a detail critical for formulation chemists.

In pharmaceuticals, 2-Oxohexanoic Acid Sodium Salt serves as a precursor for heterocyclic compounds, addressing trending demand for sustainable drug intermediates. Its role in synthesizing flavor enhancers aligns with the food industry’s focus on clean-label ingredients. A rising Google trend involves its potential in biodegradable chelators, reflecting eco-conscious industrial shifts.

Analytical methods like HPLC and NMR (common search terms) are employed to verify purity, which typically exceeds 95% for commercial grades. Users frequently ask about storage conditions—recommendations include airtight containers at ambient temperature, away from moisture. Unlike some carboxylates, it exhibits low hygroscopicity, reducing handling challenges.

The compound’s safety profile is another hotspot. While not classified as hazardous, gloves and goggles are advised during handling, per laboratory safety standards. Queries about alternative sodium salts (e.g., 2-oxopentanoate) often arise; however, its hexyl chain provides distinct steric and electronic effects for tailored applications.

Emerging studies link 2-Oxohexanoic Acid Sodium Salt to mitochondrial metabolism modulation, a trending topic in life sciences. This aligns with PubMed’s rising keyword “metabolite analogs.” Its compatibility with green chemistry principles (e.g., low toxicity, renewable derivability) further boosts its appeal in R&D.

For procurement, suppliers emphasize batch-to-batch consistency, a key concern in forums. Pricing trends correlate with sodium availability, with regional variations noted. Regulatory compliance (e.g., REACH, FDA GRAS) is frequently searched, though current status is non-restrictive.

In summary, 2-Oxohexanoic Acid Sodium Salt (CAS 13022-85-0) bridges academic and industrial needs, driven by its adaptable chemistry. As sustainable and precision chemistry trends grow, its demand is poised to expand, particularly in bio-based material synthesis and high-value pharmaceutical intermediates.

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