• 1. An antimonate pyrochlore (H1.23Sr0.45SbO3.48) for photocatalytic oxidation of benzene: effective oxygen usage and excellent activity?
  Jing Chen,Yu Shao,Danzhen Li J. Mater. Chem. A, 2017,5, 937-941
• 2. An integrated system for field analysis of Cd(ii) and Pb(ii) via preconcentration using nano-TiO2/cellulose paper composite and subsequent detection with a portable X-ray fluorescence spectrometer?
  Xiaofeng Lin RSC Adv., 2016,6, 9002-9006
• 3. An antioxidant self-healing hydrogel for 3D cell cultures?
  Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
• 4. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
• 5. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873

• Material Chemicals Colorants and Pigments Dyes
• Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients Standard Substances
• Material Chemicals Colorants and Pigments
• Natural Products and Extracts Natural Pigments

Comprehensive Guide to Alizarin Red S Sodium (CAS No. 130-22-3): Properties, Applications, and Market Insights

Alizarin Red S sodium (CAS No. 130-22-3) is a widely used anthraquinone dye and biological stain with significant applications in histology, microscopy, and industrial processes. Known for its vibrant red color and excellent staining properties, this compound has become indispensable in both research and commercial settings. In this article, we delve into the chemical properties, diverse applications, and emerging trends surrounding Alizarin Red S sodium, while addressing common queries from researchers and industry professionals.

The chemical structure of Alizarin Red S sodium features a sulfonated anthraquinone backbone, which enhances its water solubility compared to its parent compound, alizarin. This modification makes it particularly useful in aqueous staining protocols. With a molecular formula of C₁₄H₇NaO₇S and a molecular weight of 342.25 g/mol, this dye exhibits strong affinity for calcium-rich tissues, making it a preferred choice for bone and cartilage staining in biological research.

One of the most frequent questions about Alizarin Red S sodium concerns its staining mechanism. The dye forms complexes with calcium ions through its hydroxyl and carbonyl groups, creating distinctive red deposits that are easily visible under light microscopy. This property has made it invaluable for studying calcification processes in various biological systems, including bone development research and pathological calcification studies.

Beyond its biological applications, Alizarin Red S sodium finds use in several industrial sectors. The textile industry employs it as a mordant dye for cotton and wool, while the paper industry utilizes it for specialty coloring applications. Recent interest in sustainable dyes has led to investigations into its potential as an eco-friendly alternative to synthetic colorants in certain applications.

The analytical chemistry field has adopted Alizarin Red S sodium for various detection methods. Its ability to form colored complexes with metal ions makes it useful for spectrophotometric determination of aluminum, fluoride, and other ions in environmental samples. Researchers are currently exploring its potential in sensor development for environmental monitoring applications.

Quality control is paramount when working with Alizarin Red S sodium. The compound typically appears as a reddish-brown powder with ≥85% dye content (as determined by spectrophotometry). Proper storage conditions (room temperature, protected from light and moisture) ensure stability and prolong shelf life. Many users inquire about dye purity testing methods, which typically involve thin-layer chromatography or UV-Vis spectroscopy.

Recent advancements in microscopy techniques have created new opportunities for Alizarin Red S sodium applications. The growing field of 3D tissue imaging benefits from its specific staining properties, allowing researchers to visualize mineralized structures in complex biological samples. Additionally, its use in developmental biology studies continues to expand as researchers investigate skeletal formation in various model organisms.

The market for Alizarin Red S sodium has shown steady growth, driven by increasing research activities in bone biology and rising demand for specialized staining reagents. Suppliers typically offer the compound in various packaging options, from small research quantities (1g, 5g) to bulk industrial amounts (1kg). Current trends indicate growing interest in high-purity grades for sensitive research applications.

Safety considerations for Alizarin Red S sodium are frequently searched topics. While not classified as hazardous, standard laboratory precautions should be observed. The compound may cause mild eye irritation, and appropriate personal protective equipment (gloves, eye protection) is recommended during handling. Proper waste disposal methods should be followed in accordance with local regulations.

Future research directions for Alizarin Red S sodium include potential applications in biomedical engineering and tissue engineering. Some studies are exploring its use in scaffold staining for bone regeneration research, while others investigate modified versions with enhanced specificity for particular calcium phosphate phases. These developments could significantly expand the utility of this versatile dye in coming years.

For researchers considering Alizarin Red S sodium for their work, protocol optimization is often necessary. Factors such as pH, staining duration, and dye concentration can significantly affect results. Many published studies provide detailed methodologies, and protocol adaptation for specific applications is common. The dye's compatibility with various fixation methods and decalcification techniques makes it particularly versatile for diverse experimental setups.

In conclusion, Alizarin Red S sodium (CAS No. 130-22-3) remains a vital tool in both research and industrial applications. Its unique staining properties, combined with ongoing developments in imaging technologies and materials science, ensure its continued relevance across multiple disciplines. As research questions become more sophisticated and techniques more advanced, this classic dye continues to find new applications in scientific exploration and technological innovation.

• 10114-40-6(Acid Alizarin Blue BB)
• 83-61-4(3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid)
• 83784-17-2(2-Anthracenesulfonicacid, 9,10-dihydro-3,4-dihydroxy-9,10-dioxo-, sodium salt (1:3))
• 145-48-2(9,10-dihydro-1,4-dihydroxy-9,10-dioxoanthracene-2-sulphonic acid)
• 6937-76-4(2,6-Anthracenedisulfonicacid, 9,10-dihydro-1,5-dihydroxy-9,10-dioxo-, sodium salt (1:2))
• 27613-78-1(Anthracenesulfonicacid, 9,10-dihydro-1,2-dihydroxy-9,10-dioxo- (8CI,9CI))
• 22297-70-7(2-Anthracenesulfonicacid, 9,10-dihydro-1,4-dihydroxy-9,10-dioxo-, sodium salt (1:1))
• 6486-92-6(2-Anthracenesulfonicacid, 9,10-dihydro-1,4-dihydroxy-9,10-dioxo-3-(4-sulfophenoxy)-)
• 6486-90-4(2-Anthracenesulfonicacid, 9,10-dihydro-1,3,4-trihydroxy-9,10-dioxo-, sodium salt (1:1))
• 74091-55-7(Palladate(2-),bis[9,10-dihydro-3-hydroxy-4-(hydroxy-kO)-9-oxo-10-(oxo-kO)-2-anthracenesulfonato(2-)]-, disodium (9CI))