• 1. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
• 2. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 3. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 4. Distributed research: a new paradigm for undergraduate research and global problem solving?
  Bruce Parkinson Energy Environ. Sci., 2010,3, 509-511
• 5. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives

Professional Introduction to 3-Thien-3-Ylbenzaldehyde (CAS No. 129746-42-5)

3-Thien-3-Ylbenzaldehyde, with the chemical formula C₁₀H₆OS, is a versatile organic compound that has garnered significant attention in the field of pharmaceutical and chemical research. This compound, identified by its CAS number 129746-42-5, is a derivative of benzaldehyde featuring a thiophene ring at the 3-position. Its unique structural properties make it a valuable intermediate in the synthesis of various bioactive molecules, particularly in the development of novel therapeutic agents.

The significance of 3-Thien-3-Ylbenzaldehyde lies in its ability to serve as a building block for more complex structures. The presence of both aromatic and heterocyclic rings provides multiple sites for functionalization, enabling chemists to design molecules with specific biological activities. In recent years, there has been a surge in research focused on thiophene-based compounds due to their demonstrated efficacy in various pharmacological applications.

One of the most compelling aspects of 3-Thien-3-Ylbenzaldehyde is its role in the synthesis of pharmacologically active compounds. For instance, studies have shown that derivatives of this molecule exhibit promising anti-inflammatory, antioxidant, and antimicrobial properties. The thiophene ring is known to enhance binding affinity to biological targets, making it an attractive scaffold for drug design. Recent advancements in computational chemistry have further facilitated the rational design of such derivatives, allowing researchers to predict and optimize their biological activities with greater precision.

In the realm of medicinal chemistry, the utility of 3-Thien-3-Ylbenzaldehyde extends beyond simple intermediates. Researchers have utilized this compound to develop novel inhibitors targeting enzymes involved in critical metabolic pathways. For example, derivatives of this molecule have been explored as potential inhibitors of cyclin-dependent kinases (CDKs), which are implicated in cancer cell proliferation. The benzaldehyde moiety facilitates hydrogen bonding interactions with key residues in the enzyme active site, while the thiophene ring contributes to hydrophobic stabilization.

The synthesis of 3-Thien-3-Ylbenzaldehyde typically involves multi-step organic transformations, starting from readily available precursors such as thiophene and benzaldehyde derivatives. Modern synthetic methodologies have improved the efficiency and scalability of these processes, making it more feasible to produce large quantities for research and industrial applications. Catalytic approaches, including transition metal-catalyzed cross-coupling reactions, have been particularly effective in constructing the desired carbon-carbon bonds between the thiophene and benzaldehyde moieties.

The pharmacological evaluation of 3-Thien-3-Ylbenzaldehyde-based compounds has revealed several intriguing findings. Preclinical studies have demonstrated that certain derivatives exhibit significant anti-inflammatory effects by modulating cytokine production and inhibiting inflammatory signaling pathways. Additionally, some analogs have shown potent antimicrobial activity against Gram-positive bacteria, suggesting potential applications in treating resistant infections. These findings underscore the therapeutic promise of this class of compounds.

The integration of structural biology and computational modeling has further illuminated the mechanistic basis of action for these derivatives. High-resolution crystal structures of protein-ligand complexes have provided insights into how these molecules interact with biological targets at an atomic level. This information has been instrumental in designing next-generation compounds with improved selectivity and efficacy. Furthermore, virtual screening techniques have accelerated the discovery process by identifying novel scaffolds based on the known binding modes of 3-Thien-3-Ylbenzaldehyde-derived ligands.

The industrial relevance of 3-Thien-3-Ylbenzaldehyde is also reflected in its application as a key intermediate in fine chemical synthesis. Pharmaceutical companies and contract research organizations (CROs) frequently utilize this compound to develop proprietary drug candidates. Its structural versatility allows for rapid diversification into a wide array of analogs, each with distinct pharmacological profiles. This flexibility has made it a preferred choice for medicinal chemists seeking to explore new chemical spaces.

In conclusion, 3-Thien-3-Ylbenzaldehyde (CAS No. 129746-42-5) represents a fascinating compound with broad applications in pharmaceutical research and drug development. Its unique structural features enable the synthesis of bioactive molecules with diverse therapeutic potentials. As research continues to uncover new applications and refine synthetic methodologies, this compound is poised to remain a cornerstone in medicinal chemistry innovation.

• 2404-87-7(3-Phenylthiophene)
• 137320-59-3([3,3'-Bithiophene]-5-carbaldehyde)
• 20608-89-3(3-(Thiophen-3-yl)benzoic acid)
• 99902-03-1(2-(Thiophen-3-yl)benzaldehyde)
• 29886-64-4(4-(Thiophen-3-yl)benzoic acid)
• 172035-84-6(1-(4-(Thiophen-3-yl)phenyl)ethanone)
• 157730-74-0(4-(Thiophen-3-yl)benzaldehyde)
• 864135-48-8(3-(3-Methylphenyl)thiophene)
• 852318-16-2(Benzo[b]thiophene-2-carboxylic acid,3-[2-(4-methylphenyl)-2-oxoethoxy]-, ethyl ester)
• 26170-87-6(4-Phenylthiophene-2-carboxaldehyde)