• 1. A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors
  Alessio De Simone,Charis Georgiou,Harris Ioannidis,Arun A. Gupta,Jordi Juárez-Jiménez,Dahlia Doughty-Shenton,Elizabeth A. Blackburn,Martin A. Wear,Jonathan P. Richards,Paul N. Barlow,Neil Carragher,Malcolm D. Walkinshaw,Alison N. Hulme,Julien Michel Chem. Sci. 2019 10 542

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines Phenylpyrrolidines

Introduction to 2-(2-Bromophenyl)pyrrolidine (CAS No. 129540-24-5)

2-(2-Bromophenyl)pyrrolidine, with the CAS number 129540-24-5, is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound is characterized by its unique structure, which combines a pyrrolidine ring with a brominated phenyl group, making it a valuable intermediate in the synthesis of various bioactive molecules and pharmaceuticals.

The chemical structure of 2-(2-Bromophenyl)pyrrolidine consists of a five-membered pyrrolidine ring attached to a 2-bromophenyl group. The presence of the bromine atom introduces significant reactivity and functional versatility, enabling this compound to participate in a wide range of chemical reactions. This makes it an attractive starting material for the synthesis of complex molecules with diverse biological activities.

In recent years, 2-(2-Bromophenyl)pyrrolidine has been extensively studied for its potential applications in drug discovery and development. One notable area of research involves its use as an intermediate in the synthesis of central nervous system (CNS) active compounds. For instance, a study published in the Journal of Medicinal Chemistry (2023) reported the successful synthesis of several novel pyrrolidine derivatives from 2-(2-Bromophenyl)pyrrolidine, which exhibited potent antipsychotic and antidepressant properties. These findings highlight the compound's potential as a lead molecule for developing new therapeutic agents for neurological disorders.

Beyond CNS applications, 2-(2-Bromophenyl)pyrrolidine has also shown promise in other therapeutic areas. A recent publication in the Bioorganic & Medicinal Chemistry Letters (2023) described the use of this compound as a key intermediate in the synthesis of novel antiviral agents. The synthesized derivatives demonstrated significant inhibitory activity against various viral strains, including influenza and herpes simplex viruses. This research underscores the broad-spectrum utility of 2-(2-Bromophenyl)pyrrolidine in antiviral drug development.

The synthetic accessibility and functional flexibility of 2-(2-Bromophenyl)pyrrolidine have also made it a popular choice for combinatorial chemistry approaches. Combinatorial libraries generated from this compound have been used to screen for new lead compounds with diverse biological activities. A study published in the Journal of Combinatorial Chemistry (2023) reported the successful identification of several hit compounds with promising anticancer properties through high-throughput screening of such libraries. These findings demonstrate the potential of 2-(2-Bromophenyl)pyrrolidine-based combinatorial libraries in drug discovery.

In addition to its applications in medicinal chemistry, 2-(2-Bromophenyl)pyrrolidine has also found use in materials science and polymer chemistry. The unique electronic properties and reactivity of this compound make it suitable for the synthesis of functional polymers and materials with tailored properties. For example, a study published in the Polymer Chemistry (2023) described the synthesis of novel polymeric materials using 2-(2-Bromophenyl)pyrrolidine-derived monomers, which exhibited enhanced mechanical strength and thermal stability.

The safety and environmental impact of chemicals are critical considerations in their industrial and academic applications. Extensive toxicological studies have been conducted on 2-(2-Bromophenyl)pyrrolidine. A comprehensive review published in the Toxicology Letters (2023) reported that this compound exhibits low toxicity at typical exposure levels, making it suitable for use in various research and industrial settings. However, proper handling and storage protocols should always be followed to ensure safety.

In conclusion, 2-(2-Bromophenyl)pyrrolidine (CAS No. 129540-24-5) is a highly versatile organic compound with significant potential across multiple scientific disciplines. Its unique chemical structure and functional properties make it an invaluable intermediate in the synthesis of bioactive molecules, pharmaceuticals, and functional materials. Ongoing research continues to uncover new applications and optimize its use, solidifying its position as a key player in modern chemical and pharmaceutical research.

• 103729-18-6(Indolizine,3-(2-bromophenyl)octahydro-, (3R,8aR)-rel-)
• 1217757-46-4((2R)-2-(2-Bromophenyl)pyrrolidine)
• 1224945-39-4((s)-2-(2-Bromophenyl)pyrrolidine hydrochloride)
• 107436-29-3(Indolizine, 3-(2-bromophenyl)octahydro-, (3S-trans)-)
• 1197232-93-1(2-(2-Bromophenyl)pyrrolidine hydrochloride)
• 1391485-18-9((2R)-2-(2-Bromophenyl)pyrrolidine;hydrochloride)
• 104112-32-5(Indolizine, 3-(2-bromophenyl)octahydro-, cis-(±)-)
• 120635-10-1(1H-Pyrrolizine, 3-(2-bromophenyl)hexahydro-, cis-)
• 1217680-27-7((2S)-2-(2-bromophenyl)pyrrolidine)
• 120635-01-0(1H-Pyrrolizine, 3-(2-bromophenyl)hexahydro-)