Cas no 128858-43-5 (Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite)
Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite is a specialized phosphoramidite reagent used in oligonucleotide synthesis, particularly in the preparation of modified DNA or RNA sequences. Its key advantages include high reactivity and selectivity in phosphoramidite coupling reactions, ensuring efficient incorporation of p-chlorobenzyl-protected nucleotides. The diisopropylamino group enhances stability, reducing side reactions during synthesis. This compound is particularly valuable in producing oligonucleotides with tailored modifications for research in molecular biology, diagnostics, and therapeutic development. Its robust performance under standard solid-phase synthesis conditions makes it a reliable choice for precision applications requiring controlled phosphitylation. Proper handling under inert conditions is recommended to maintain its reactivity.
128858-43-5 structure
Product Name:Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite
CAS No:128858-43-5
MF:C20H26Cl2NO2P
MW:414.305704593658
CID:824644
PubChem ID:4096368
Update Time:2025-06-21
Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite Chemical and Physical Properties
Names and Identifiers
-
- Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite
- Bis(1-Methylethyl)phosphoraMidous Acid Bis[(4-chlorophenyl)Methyl] Ester
- N-[bis[(4-chlorophenyl)methoxy]phosphanyl]-N-propan-2-ylpropan-2-amine
- Phosphoramidous acid, N,N-bis(1-methylethyl)-, bis[(4-chlorophenyl)methyl] ester
- Bis(4-chlorobenzyl) diisopropylphosphoramidite
- 128858-43-5
- DTXSID10399270
- AKOS025294265
- SCHEMBL5970336
- J-005633
-
- Inchi： 1S/C20H26Cl2NO2P/c1-15(2)23(16(3)4)26(24-13-17-5-9-19(21)10-6-17)25-14-18-7-11-20(22)12-8-18/h5-12,15-16H,13-14H2,1-4H3
- InChI Key： OCQXCPQSBNWTOF-UHFFFAOYSA-N
- SMILES： ClC1C=CC(=CC=1)COP(N(C(C)C)C(C)C)OCC1C=CC(=CC=1)Cl
Computed Properties
- Exact Mass: 413.10800
- Monoisotopic Mass: 413.1078215g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 26
- Rotatable Bond Count: 9
- Complexity: 350
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 6.1
- Topological Polar Surface Area: 21.7?2
Experimental Properties
- Stability/Shelf Life: Moisture Sensitive
- PSA: 35.29000
- LogP: 7.07250
Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | D432500-1g |
Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite |
128858-43-5 | 1g |
$ 148.00 | 2023-09-07 | ||
| TRC | D432500-2g |
Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite |
128858-43-5 | 2g |
$170.00 | 2023-05-18 | ||
| TRC | D432500-2.5g |
Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite |
128858-43-5 | 2.5g |
$181.00 | 2023-05-18 | ||
| TRC | D432500-5g |
Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite |
128858-43-5 | 5g |
$181.00 | 2023-05-18 | ||
| TRC | D432500-10g |
Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite |
128858-43-5 | 10g |
$572.00 | 2023-05-18 | ||
| TRC | D432500-25g |
Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite |
128858-43-5 | 25g |
$1312.00 | 2023-05-18 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-211284-2.5 g |
Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite, |
128858-43-5 | 2.5 g |
￥2,858.00 | 2023-07-10 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-211284-2.5g |
Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite, |
128858-43-5 | 2.5g |
￥2858.00 | 2023-09-05 | ||
| A2B Chem LLC | AA44431-1g |
Phosphoramidous acid, N,N-bis(1-methylethyl)-, bis[(4-chlorophenyl)methyl] ester |
128858-43-5 | 1g |
$254.00 | 2024-01-04 |
Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite Related Literature
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J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
-
Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
-
Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
-
Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
-
Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
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