• 1. Distinction of trans–cis photoisomers with comparable optical properties in multiple-state photochromic systems – examining a molecule with three azobenzenes via in situ irradiation NMR spectroscopy?
  Jonas Kind,Lukas Kaltschnee,Martin Leyendecker,Christina M. Thiele Chem. Commun., 2016,52, 12506-12509
• 2. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 3. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 4. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 5. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Dialkyl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Dialkyl ethers

Comprehensive Overview of THP-PEG4-OH (CAS No. 128660-97-9): Applications and Innovations in Modern Chemistry

THP-PEG4-OH (CAS No. 128660-97-9) is a specialized polyethylene glycol (PEG) derivative widely utilized in bioconjugation, drug delivery, and material science. Its unique structure, featuring a tetrahydropyran (THP) protecting group and a hydroxyl-terminated PEG4 spacer, offers exceptional solubility and biocompatibility. This compound has garnered significant attention due to its versatility in click chemistry applications and its role in proteolysis-targeting chimeras (PROTACs), a cutting-edge therapeutic strategy. Researchers and pharmaceutical companies are increasingly exploring THP-PEG4-OH for its ability to enhance payload delivery while minimizing immunogenicity.

The growing demand for PEGylated compounds in biopharmaceuticals has positioned THP-PEG4-OH as a critical building block. Its CAS No. 128660-97-9 is frequently searched in databases like PubChem and Reaxys, reflecting its importance in organic synthesis. Recent studies highlight its utility in ADC (antibody-drug conjugate) development, where the THP group ensures stability during synthesis. Additionally, its hydroxyl functionality allows for further modifications, making it ideal for crosslinking reactions in hydrogel formulations—a hot topic in 3D bioprinting and tissue engineering.

One of the most searched questions regarding THP-PEG4-OH is its solubility profile and compatibility with aqueous buffers. Empirical data confirm its excellent water solubility, a trait highly valued in nanoparticle drug delivery systems. The compound’s PEG4 spacer also reduces protein adsorption, a key concern in stealth drug formulations. Furthermore, its THP group can be selectively deprotected under mild acidic conditions, enabling controlled release mechanisms—an area of intense research in cancer therapeutics and targeted drug delivery.

Innovations in green chemistry have further propelled interest in THP-PEG4-OH. Its synthesis often employs environmentally friendly catalysts, aligning with the global push for sustainable manufacturing. The compound’s role in biodegradable polymers is another trending topic, particularly for applications in medical implants and eco-friendly packaging. Notably, its low toxicity and high biodegradability make it a preferred choice over traditional linkers in next-generation therapeutics.

From an industrial perspective, THP-PEG4-OH (CAS No. 128660-97-9) is pivotal in scaling up GMP-compliant production processes. Its batch-to-batch consistency and high purity standards are critical for regulatory approvals in FDA submissions. As the demand for personalized medicine grows, so does the need for reliable PEG-based reagents like THP-PEG4-OH, underscoring its enduring relevance in both academic and industrial research.

• 830326-91-5(2H-Pyran, 2,2'-[1,7-heptanediylbis(oxy)]bis[tetrahydro-)
• 71033-27-7(2-[2-(oxan-2-yloxy)ethoxy]oxane)
• 88773-84-6(2H-Pyran, tetrahydro-2-(undecyloxy)-)
• 6581-66-4(2-Methoxytetrahydropyran)
• 76102-74-4(1-Pentanol, 5-[(tetrahydro-2H-pyran-2-yl)oxy]-)
• 2162-31-4(THP-PEG1-alcohol)
• 4819-82-3(2H-Pyran,tetrahydro-2-(2-methoxyethoxy)-)
• 87989-45-5(2H-Pyran-3-yl, tetrahydro-2-methoxy-)
• 60221-37-6(THP-PEG4)
• 2163-11-3(Tetrahydropyranyldiethyleneglycol)