• 1. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 2. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 3. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 4. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 5. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693

Introduction to 4-Nitrotoluene-2,3,5,6-D4 (CAS No. 1276197-16-0)

4-Nitrotoluene-2,3,5,6-D4 (CAS No. 1276197-16-0) is a deuterated derivative of 4-nitrotoluene, a compound widely used in various scientific and industrial applications. The deuterium atoms in this compound provide unique advantages in analytical chemistry and nuclear magnetic resonance (NMR) spectroscopy, making it an essential tool for researchers and scientists.

The chemical structure of 4-Nitrotoluene-2,3,5,6-D4 consists of a benzene ring with a nitro group (-NO₂) at the para position and four deuterium atoms (D) substituting the hydrogen atoms at the 2, 3, 5, and 6 positions. This specific isotopic labeling offers enhanced stability and reduced background interference in NMR studies, which is crucial for accurate and reliable data interpretation.

In recent years, the use of deuterated compounds like 4-Nitrotoluene-2,3,5,6-D4 has gained significant attention in the field of pharmaceutical research. Deuterium labeling can help in understanding the metabolic pathways of drugs and their interactions with biological systems. For instance, a study published in the Journal of Medicinal Chemistry demonstrated that deuterated analogs of certain drugs exhibited improved pharmacokinetic properties and reduced toxicity compared to their non-deuterated counterparts.

The synthesis of 4-Nitrotoluene-2,3,5,6-D4 involves several steps, including the deuteration of toluene followed by nitration. The deuteration process typically uses heavy water (D₂O) or deuterium gas (D₂) as the source of deuterium. The nitration step can be achieved using a mixture of concentrated nitric acid and sulfuric acid. The precise control of reaction conditions is crucial to ensure high yields and purity of the final product.

In addition to its applications in NMR spectroscopy and pharmaceutical research, 4-Nitrotoluene-2,3,5,6-D4 is also used in environmental studies to trace the fate and transport of organic pollutants. Deuterated compounds can serve as non-toxic tracers that mimic the behavior of their non-deuterated counterparts without posing environmental risks. This makes them valuable tools for monitoring pollution levels and assessing remediation strategies.

The safety profile of 4-Nitrotoluene-2,3,5,6-D4 is generally similar to that of its non-deuterated form. However, the presence of deuterium atoms can slightly alter its physical properties such as boiling point and solubility. Users should handle this compound with appropriate personal protective equipment (PPE) and follow standard laboratory safety protocols to ensure a safe working environment.

In conclusion, 4-Nitrotoluene-2,3,5,6-D4 (CAS No. 1276197-16-0) is a versatile compound with a wide range of applications in analytical chemistry, pharmaceutical research, and environmental studies. Its unique isotopic labeling provides valuable insights into molecular structures and biological processes, making it an indispensable tool for modern scientific research.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)