• 1. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 2. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 3. Excellent humidity sensor based on ultrathin HKUST-1 nanosheets?
  Qiaoe Wang,Meiling Lian,Xiaowen Zhu,Xu Chen RSC Adv., 2021,11, 192-197
• 4. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
• 5. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Terphenyls

Research Briefing on 4-(4,5-diphenyl-1H-benzimidazol-2-yl)benzoyl chloride;hydrochloride (CAS: 1274903-55-7)

4-(4,5-diphenyl-1H-benzimidazol-2-yl)benzoyl chloride;hydrochloride (CAS: 1274903-55-7) is a specialized chemical compound that has garnered significant attention in the field of chemical biology and pharmaceutical research. This benzimidazole derivative is recognized for its potential as a key intermediate in the synthesis of bioactive molecules, particularly those targeting protein-protein interactions and enzyme inhibition. Recent studies have explored its utility in the development of novel therapeutic agents, with a focus on its structural versatility and reactivity.

The compound's unique structure, featuring a benzimidazole core substituted with phenyl groups and a benzoyl chloride moiety, makes it a valuable scaffold for drug discovery. Researchers have leveraged its electrophilic properties to design covalent inhibitors, particularly for kinases and other enzymes involved in signaling pathways. A 2023 study published in the Journal of Medicinal Chemistry highlighted its use in the synthesis of irreversible inhibitors targeting EGFR mutants, demonstrating promising preclinical efficacy in non-small cell lung cancer models.

In addition to its role in covalent inhibitor design, 4-(4,5-diphenyl-1H-benzimidazol-2-yl)benzoyl chloride;hydrochloride has been investigated for its potential in fluorescent probe development. Its benzimidazole core exhibits intrinsic fluorescence properties, which have been exploited to create sensors for detecting metal ions and biomolecules. A recent ACS Chemical Biology publication (2024) described its incorporation into a turn-on fluorescent probe for zinc ion detection in live cells, showcasing its utility in chemical biology applications.

The synthetic accessibility of this compound has also been a subject of optimization efforts. Recent advancements in its preparation, as reported in Organic Process Research & Development (2023), have focused on improving yield and purity through novel catalytic systems and solvent optimization. These process improvements are critical for scaling up production to meet the growing demand in both academic and industrial research settings.

Safety and handling considerations for 4-(4,5-diphenyl-1H-benzimidazol-2-yl)benzoyl chloride;hydrochloride have been addressed in recent regulatory assessments. As a reactive acyl chloride derivative, proper storage conditions (under inert atmosphere, at low temperatures) and handling protocols (use of personal protective equipment) are emphasized in material safety data sheets. Its hydrochloride salt form offers improved stability compared to the free base, making it more suitable for long-term storage and transportation.

Looking forward, the compound's applications are expected to expand into new therapeutic areas. Ongoing research is exploring its potential in targeted protein degradation (PROTACs) and as a warhead in antibody-drug conjugates (ADCs). The unique combination of its benzimidazole pharmacophore and reactive acyl chloride group positions it as a versatile building block for next-generation drug discovery platforms.

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