Cas no 127371-54-4 (Methyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate)

Methyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate is a fluorinated quinolone derivative with a cyclopropyl substituent at the N1 position, exhibiting structural features associated with antimicrobial activity. The difluoro substitution at the 6,7 positions enhances lipophilicity and membrane permeability, while the ester group at the 3-position offers synthetic versatility for further modifications. This compound serves as a key intermediate in the synthesis of advanced quinolone-based pharmaceuticals, particularly antibiotics targeting DNA gyrase and topoisomerase IV. Its rigid cyclopropane ring contributes to metabolic stability, and the carboxylate ester functionality allows for controlled hydrolysis to the corresponding carboxylic acid, a common pharmacophore in bioactive quinolones. The compound is typically handled under controlled conditions due to its potential reactivity.
Methyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate structure
127371-54-4 structure
Product Name:Methyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
CAS No:127371-54-4
MF:C14H11F2NO3
MW:279.238850831985
MDL:MFCD30179694
CID:2449795
PubChem ID:11492850
Update Time:2025-10-29

Methyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate Chemical and Physical Properties

Names and Identifiers

    • METHYL 1-CYCLOPROPYL-6,7-DIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
    • methyl 1-cyclopropyl-6,7-difluoro-4-oxoquinoline-3-carboxylate
    • methyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
    • 1-Cyclopropyl-4-oxo-6,7-difluoro-1,4-dihydroquinoline-3-carboxylic acid methyl ester
    • methyl 1-cyclopropyl-6,7-difluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylate
    • SCHEMBL9577810
    • WGZPDLDHADAWSC-UHFFFAOYSA-N
    • 127371-54-4
    • DB-198396
    • Methyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
    • MDL： MFCD30179694
    • Inchi： 1S/C14H11F2NO3/c1-20-14(19)9-6-17(7-2-3-7)12-5-11(16)10(15)4-8(12)13(9)18/h4-7H,2-3H2,1H3
    • InChI Key： WGZPDLDHADAWSC-UHFFFAOYSA-N
    • SMILES： FC1C(=CC2C(C(C(=O)OC)=CN(C=2C=1)C1CC1)=O)F

Computed Properties

  • Exact Mass: 279.07069954 g/mol
  • Monoisotopic Mass: 279.07069954 g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 20
  • Rotatable Bond Count: 3
  • Complexity: 475
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Molecular Weight: 279.24
  • XLogP3: 1.6
  • Topological Polar Surface Area: 46.6

Methyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
eNovation Chemicals LLC
D540900-25g
METHYL 1-CYCLOPROPYL-6,7-DIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
 127371-54-4 97%
25g
 $300 2024-06-05
eNovation Chemicals LLC
D540900-100g
METHYL 1-CYCLOPROPYL-6,7-DIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
 127371-54-4 97%
100g
 $800 2024-06-05
eNovation Chemicals LLC
D540900-500g
METHYL 1-CYCLOPROPYL-6,7-DIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
 127371-54-4 97%
500g
 $1500 2024-06-05
eNovation Chemicals LLC
D540900-1kg
METHYL 1-CYCLOPROPYL-6,7-DIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
 127371-54-4 97%
1kg
 $2000 2024-06-05
Ambeed
A876975-10mg
Methyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
 127371-54-4 97%
10mg
 $68.0 2025-03-16
eNovation Chemicals LLC
D540900-25g
METHYL 1-CYCLOPROPYL-6,7-DIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
 127371-54-4 97%
25g
 $300 2025-03-01
eNovation Chemicals LLC
D540900-500g
METHYL 1-CYCLOPROPYL-6,7-DIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
 127371-54-4 97%
500g
 $1500 2025-03-01
eNovation Chemicals LLC
D540900-100g
METHYL 1-CYCLOPROPYL-6,7-DIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
 127371-54-4 97%
100g
 $800 2025-03-01
eNovation Chemicals LLC
D540900-1kg
METHYL 1-CYCLOPROPYL-6,7-DIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
 127371-54-4 97%
1kg
 $2000 2025-03-01
eNovation Chemicals LLC
D540900-25g
METHYL 1-CYCLOPROPYL-6,7-DIFLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
 127371-54-4 97%
25g
 $300 2025-02-19

Methyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate Related Literature

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