• 1. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 2. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 3. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 4. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 5. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459

• Solvents and Organic Chemicals Organic Compounds Organohalogen compounds Alkyl halides Cyclohexyl halides

Research Brief on 3-Fluorocyclohexanamine (CAS: 1273566-51-0): Recent Advances and Applications in Chemical Biology and Pharmaceutical Sciences

3-Fluorocyclohexanamine (CAS: 1273566-51-0) is a fluorinated cyclohexylamine derivative that has garnered significant attention in recent years due to its potential applications in medicinal chemistry and drug discovery. This compound, characterized by the presence of a fluorine atom at the 3-position of the cyclohexane ring, exhibits unique physicochemical properties that make it a valuable building block for the synthesis of bioactive molecules. Recent studies have explored its utility as a key intermediate in the development of novel therapeutics, particularly in the areas of central nervous system (CNS) disorders and metabolic diseases.

A 2023 study published in the Journal of Medicinal Chemistry investigated the role of 3-Fluorocyclohexanamine in the design of selective serotonin reuptake inhibitors (SSRIs). The researchers demonstrated that the incorporation of this fluorinated amine moiety into the scaffold of known SSRIs significantly improved their blood-brain barrier permeability and metabolic stability. The study utilized molecular docking simulations and in vitro assays to validate the enhanced binding affinity of these derivatives to the serotonin transporter (SERT), suggesting potential applications in the treatment of depression and anxiety disorders.

In the field of radiopharmaceuticals, 3-Fluorocyclohexanamine has been employed as a precursor for the synthesis of fluorine-18 labeled tracers for positron emission tomography (PET) imaging. A recent publication in ACS Chemical Neuroscience (2024) described the development of a novel PET probe targeting sigma-1 receptors, where 3-Fluorocyclohexanamine served as the core structure. The probe exhibited high specificity and favorable pharmacokinetics in preclinical models, highlighting its potential for neuroimaging applications in neurodegenerative diseases such as Alzheimer's and Parkinson's.

The synthetic accessibility of 3-Fluorocyclohexanamine has also been a subject of recent optimization efforts. A 2024 paper in Organic Process Research & Development reported an improved catalytic hydrogenation protocol for its preparation from 3-fluorocyclohexanone, achieving higher yields (85-90%) and excellent enantioselectivity (>99% ee) when using a chiral ruthenium catalyst. This advancement addresses previous challenges in the large-scale production of enantiomerically pure 3-Fluorocyclohexanamine, which is crucial for pharmaceutical applications where stereochemistry plays a critical role in biological activity.

Emerging research has also explored the metabolic fate of 3-Fluorocyclohexanamine-containing compounds. A recent study in Drug Metabolism and Disposition (2023) characterized the major Phase I and Phase II metabolites of several 3-Fluorocyclohexanamine derivatives, identifying fluorinated cyclohexanol and glucuronide conjugates as predominant metabolites. These findings provide valuable insights for drug design, particularly in optimizing metabolic stability and minimizing potential toxicity concerns associated with fluorinated compounds.

Looking forward, the versatility of 3-Fluorocyclohexanamine continues to inspire innovative applications across chemical biology and pharmaceutical sciences. Current research directions include its incorporation into proteolysis-targeting chimeras (PROTACs) for targeted protein degradation, as well as its use in the development of fluorinated analogs of natural products with enhanced pharmacological properties. The compound's unique combination of structural features and favorable drug-like characteristics ensures its ongoing relevance in medicinal chemistry research.

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• 921753-34-6(3,3-difluorocyclohexan-1-amine)
• 932706-30-4(cis-4-fluorocyclohexanamine;hydrochloride)
• 932779-47-0((1S,3R)-3-fluorocyclopentan-1-amine)
• 1792190-80-7((1R,3S)-3-fluorocyclopentan-1-amine)
• 1354425-58-3(trans-3-fluorocyclopentan-1-amine)
• 1448310-31-3(4-fluorocyclohexanamine;hydrochloride)
• 923595-66-8(cis-4-fluorocyclohexanamine)