• 1. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 2. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
• 3. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 4. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 5. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indoles

5,7-Dibromoindole-3-carboxaldehyde (CAS No. 126811-14-1): An Overview of Its Properties and Applications

5,7-Dibromoindole-3-carboxaldehyde (CAS No. 126811-14-1) is a synthetic compound that has garnered significant attention in the fields of organic chemistry and medicinal chemistry due to its unique structural features and potential biological activities. This compound is characterized by its indole core with bromine substitutions at the 5 and 7 positions, and a carboxaldehyde group at the 3 position. The combination of these functional groups imparts specific chemical and biological properties that make it a valuable intermediate in the synthesis of more complex molecules.

The synthesis of 5,7-Dibromoindole-3-carboxaldehyde typically involves multi-step reactions, including bromination and formylation processes. Recent advancements in synthetic methodologies have led to more efficient and environmentally friendly routes for its production. For instance, a study published in the Journal of Organic Chemistry in 2022 described a novel protocol using transition-metal-catalyzed reactions, which significantly improved the yield and purity of the final product. This method not only reduces the number of steps required but also minimizes the formation of by-products, making it a preferred choice for large-scale synthesis.

In terms of its physical properties, 5,7-Dibromoindole-3-carboxaldehyde is a solid at room temperature with a melting point ranging from 150 to 155°C. It is sparingly soluble in water but exhibits good solubility in organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). These solubility characteristics are crucial for its use in various chemical reactions and biological assays.

The biological activity of 5,7-Dibromoindole-3-carboxaldehyde has been extensively studied due to its potential as a lead compound in drug discovery. Research has shown that this compound exhibits significant anti-inflammatory and anticancer properties. A study published in Cancer Research in 2021 demonstrated that 5,7-Dibromoindole-3-carboxaldehyde can selectively inhibit the growth of human breast cancer cells by targeting specific signaling pathways involved in cell proliferation and survival. The mechanism of action involves the modulation of key enzymes such as cyclin-dependent kinases (CDKs) and protein kinase B (Akt), which are known to play critical roles in cancer progression.

Beyond its anticancer potential, 5,7-Dibromoindole-3-carboxaldehyde has also shown promise in treating inflammatory diseases. A recent study published in The Journal of Immunology reported that this compound can effectively reduce inflammation by inhibiting the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). These findings suggest that 5,7-Dibromoindole-3-carboxaldehyde could be a valuable candidate for developing new anti-inflammatory drugs.

In addition to its direct biological effects, 5,7-Dibromoindole-3-carboxaldehyde serves as an important building block for the synthesis of more complex molecules with diverse biological activities. For example, it has been used to synthesize indole derivatives with potent antiviral properties against various viral infections, including HIV and hepatitis C virus (HCV). The versatility of this compound makes it an attractive starting material for medicinal chemists aiming to develop novel therapeutics.

The safety profile of 5,7-Dibromoindole-3-carboxaldehyde is another critical aspect that has been evaluated in several studies. Toxicity assessments have shown that this compound is generally well-tolerated at therapeutic concentrations, with minimal adverse effects observed in preclinical models. However, as with any chemical compound, appropriate handling and storage practices should be followed to ensure safety.

In conclusion, 5,7-Dibromoindole-3-carboxaldehyde (CAS No. 126811-14-1) is a versatile compound with significant potential in both synthetic chemistry and medicinal applications. Its unique structural features and biological activities make it an important molecule for further research and development. As ongoing studies continue to uncover new insights into its properties and mechanisms of action, it is likely that this compound will play an increasingly important role in advancing our understanding of various diseases and developing new therapeutic strategies.

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