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  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 2. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Phenylpyridines

Introduction to 5-(4-Chlorophenyl)nicotinonitrile (CAS No. 1267613-64-8)

5-(4-Chlorophenyl)nicotinonitrile, with the chemical formula C₁₁H₆ClN₂, is a significant compound in the field of pharmaceutical and agrochemical research. This compound, identified by its CAS number CAS NO.1267613-64-8, has garnered attention due to its versatile applications and structural properties that make it a valuable intermediate in synthetic chemistry.

The molecular structure of 5-(4-Chlorophenyl)nicotinonitrile features a nicotinonitrile core substituted with a 4-chlorophenyl group. This unique arrangement contributes to its reactivity and potential utility in various chemical transformations. The presence of both electron-withdrawing and electron-donating groups in its structure allows for diverse functionalization, making it a promising candidate for further derivatization and application development.

In recent years, 5-(4-Chlorophenyl)nicotinonitrile has been extensively studied for its potential role in the development of novel pharmaceuticals. Its structural motif is reminiscent of several bioactive molecules, suggesting that it could serve as a scaffold for drug discovery. Specifically, the nitrile group and the chlorophenyl moiety are known to interact with biological targets in ways that could be exploited for therapeutic purposes.

One of the most intriguing aspects of 5-(4-Chlorophenyl)nicotinonitrile is its ability to participate in various chemical reactions, including nucleophilic additions, cyclizations, and metal-catalyzed cross-coupling reactions. These reactions are fundamental to the synthesis of complex organic molecules, and 5-(4-Chlorophenyl)nicotinonitrile's compatibility with them makes it an invaluable tool in synthetic organic chemistry.

Recent research has highlighted the compound's utility in the synthesis of heterocyclic compounds, which are prevalent in many pharmaceuticals. The nicotinonitrile moiety can be transformed into other functional groups such as amides, carboxylic acids, and thiols, depending on the reaction conditions. This flexibility allows chemists to tailor the properties of the compound for specific applications.

The agrochemical industry has also shown interest in 5-(4-Chlorophenyl)nicotinonitrile due to its potential as a precursor for pesticides and herbicides. The structural features of this compound can be modified to enhance its biological activity against pests while maintaining environmental safety. Such developments are crucial for addressing the growing challenges in agricultural productivity and sustainability.

In addition to its pharmaceutical and agrochemical applications, 5-(4-Chlorophenyl)nicotinonitrile has been explored for its role in materials science. Its ability to form stable complexes with metals and other organic molecules makes it a candidate for use in catalysis and material design. These applications are particularly relevant in the context of developing sustainable and efficient chemical processes.

The synthesis of 5-(4-Chlorophenyl)nicotinonitrile typically involves multi-step reactions that require careful optimization to ensure high yields and purity. Common synthetic routes include condensation reactions between appropriate precursors followed by functional group transformations. Advances in synthetic methodologies have made it possible to produce this compound on a larger scale, facilitating its use in industrial applications.

The safety profile of 5-(4-Chlorophenyl)nicotinonitrile is another critical consideration. While it is not classified as a hazardous material under standard regulations, proper handling procedures must be followed to minimize exposure risks. This includes using appropriate personal protective equipment and ensuring good ventilation during storage and handling.

Future research directions for 5-(4-Chlorophenyl)nicotinonitrile include exploring new synthetic pathways that improve efficiency and reduce waste. Additionally, investigating its biological activity through computational modeling and experimental studies could uncover novel therapeutic applications. Collaborative efforts between academia and industry are essential to translate these findings into practical solutions.

The impact of 5-(4-Chlorophenyl)nicotinonitrile extends beyond academic research, influencing various sectors of the chemical industry. Its versatility as a building block for more complex molecules underscores its importance in drug discovery, materials science, and agrochemical development. As our understanding of its properties grows, so too will its applications across multiple fields.

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