Cas no 126544-47-6 (Ciclesonide)
Ciclesonide is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties, primarily used in the management of asthma and allergic rhinitis. Its key advantage lies in its prodrug design, where the inactive parent compound is metabolized in the lungs to its active form, desisobutyryl-ciclesonide, minimizing systemic exposure and reducing the risk of adverse effects. The drug exhibits high glucocorticoid receptor affinity and low oral bioavailability, enhancing localized efficacy while limiting systemic side effects. Its lipophilicity allows for prolonged retention in target tissues, ensuring sustained action. Ciclesonide is administered via inhalation, offering targeted delivery with a favorable safety profile, making it suitable for long-term use in respiratory conditions.
Ciclesonide structure
Product Name:Ciclesonide
CAS No:126544-47-6
MF:C32H44O7
MW:540.6876
MDL:MFCD00866004
CID:63829
PubChem ID:6918155
Update Time:2025-06-09
Ciclesonide Chemical and Physical Properties
Names and Identifiers
-
- Ciclesonide
- (R)-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde 21-isobutyrate
- Ciclesonide NEW
- RPR251526
- (11,16)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione
- Ciclesonide(RPR251526)
- (11β,16α)-16,17-[[(R)-CyclohexylMethylene]bis(oxy)]-11-hydroxy-21-(2-Methyl-1-oxopropoxy)-pregna-1,4-diene-3,20-dione
- Omnaris
- Alvesco
- Zetonna
- RPR 251526
- Ciclesonide [INN]
- S59502J185
- Osonase
- Osonide
- Omnair
- Omnaris HFA
- Alvesco HFA
- GTPL7469
- SCHEMBL3688
- Aservo EquiHaler
- BI54903
- SR-01000942227-1
- (R)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde, 21-isobutyrate
- Pregna-1,4-diene-3,20-dione, 16,17-((cyclohexylmethylene)bis(oxy))-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11beta,16alpha(R))-
- CHEBI:31397
- CICLESONIDE [ORANGE BOOK]
- HMS3714N07
- WLZ3795
- Zetonna (TN)
- CICLESONIDE (MART.)
- AC-1330
- RPR-251526
- BTR-15K
- Ciclesonide, >=98% (HPLC)
- BYK-20426
- Alvesco 80
- BDBM50247997
- CICLESONIDE [JAN]
- CS-0694790
- EX-A4195
- D01703
- CCG-269962
- Omnaris (TN)
- AKOS015994702
- CICLESONIDE [MART.]
- DB01410
- LUKZNWIVRBCLON-GXOBDPJESA-N
- SR-01000942227
- CICLESONIDE [EP MONOGRAPH]
- Ciclesonide [USAN:INN]
- el-87-6
- CICLESONIDE [VANDF]
- NS00006507
- HY-B0625R
- CICLESONIDE (EP MONOGRAPH)
- Ciclesonida
- B-9207-015
- BTR-15
- NCGC00167972-01
- Alvesco (TN)
- Ciclesonide, European Pharmacopoeia (EP) Reference Standard
- C3701
- PREGNA-1,4-DIENE-3,20-DIONE, 16,17-(((R)-CYCLOHEXYLMETHYLENE)BIS(OXY))-11-HYDROXY-21-(2-METHYL-1-OXOPROPOXY)-, (11beta,16alpha)
- [2-[(1S,2S,4R,8S,9S,11S,12S,13R)-6-Cyclohexyl-11-hydroxy-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] 2-methylpropanoate
- Alvesco 160
- Ciclesonide 100 microg/mL in Acetonitrile
- DTXSID9046659
- [2-[(1S,2S,4R,6R,8S,9S,11S,12S,13R)-6-cyclohexyl-11-hydroxy-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] 2-methylpropanoate
- 16alpha,17-((1R)-Cyclohexylmethylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione 21-(2-methylpropionate)
- ciclesonidum
- CHEMBL2040682
- BRD-K35245662-001-01-2
- DTXCID7026659
- UNII-S59502J185
- 126544-47-6
- CAS-141845-82-1
- CICLESONIDE [WHO-DD]
- R03BA08
- Ciclesonide (Standard)
- PREGNA-1,4-DIENE-3,20-DIONE, 16,17-(((R)-CYCLOHEXYLMETHYLENE)BIS(OXY))-11-HYDROXY-21-(2-METHYL-1-OXOPROPOXY)-, (11.BETA.,16.ALPHA.)
- BY-9010
- Ciclesonide (JAN/USAN/INN)
- s4646
- 2H-Naphth (2',1':4,5) indeno (1,2-d) (1,3) dioxole, pregna-1,4-diene-3,20-dione deriv.
- TBN-15
- HY-B0625
- CICLESONIDE [USAN]
- 141845-82-1
- Tox21_112486
- C72110
- Alvesco, Ciclesonide
- (11beta,16alpha)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione
- CICLESONIDE [MI]
- KS-1165
- Pregna-1,4-diene-3,20-dione, 16,17-(((R)-cyclohexylmethylene)bis(oxy))-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11beta,16alpha)-
- NCGC00167484-01
- R01AD13
- EN300-19766990
- 2-[(1S,2S,4R,6R,8S,9S,11S,12S,13R)-6-cyclohexyl-11-hydroxy-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-8-yl]-2-oxoethyl 2-methylpropanoate
- Q5119448
- 2-[(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-8-cyclohexyl-5-hydroxy-4a,6a-dimethyl-2-oxo-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-phenanthro[1',2':1,2]cyclopenta[3,4-d][1,3]dioxol-6b-yl]-2-oxoethyl 2-methylpropanoate
-
- MDL： MFCD00866004
- Inchi： 1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1
- InChI Key： LUKZNWIVRBCLON-GXOBDPJESA-N
- SMILES： O1[C@]([H])(C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])O[C@]2([H])C([H])([H])[C@@]3([H])[C@]4([H])C([H])([H])C([H])([H])C5=C([H])C(C([H])=C([H])[C@]5(C([H])([H])[H])[C@@]4([H])[C@]([H])(C([H])([H])[C@]3(C([H])([H])[H])[C@]12C(C([H])([H])OC(C([H])(C([H])([H])[H])C([H])([H])[H])=O)=O)O[H])=O
Computed Properties
- Exact Mass: 540.30900
- Monoisotopic Mass: 540.309
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 7
- Heavy Atom Count: 39
- Rotatable Bond Count: 6
- Complexity: 1100
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 8
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 99.1
- XLogP3: 5.3
Experimental Properties
- Color/Form: No data available
- Density: 1.23 g/cm3
- Melting Point: 206-213°C
- Boiling Point: 665°C at 760 mmHg
- Flash Point: 210.0±25.0 °C
- Refractive Index: 1.575
- PSA: 99.13000
- LogP: 4.70390
Ciclesonide Security Information
- Signal Word：Warning
- Hazard Statement： H315; H319; H335
- Warning Statement： P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501
- Hazardous Material transportation number：NONH for all modes of transport
- Safety Instruction： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
- HazardClass：6.1
- PackingGroup：Ⅲ
Ciclesonide Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| DC Chemicals | DC9176-1 g |
Ciclesonide |
126544-47-6 | >98% | 1g |
$300.0 | 2022-02-28 | |
| TRC | C432690-5mg |
Ciclesonide |
126544-47-6 | 5mg |
$ 91.00 | 2023-09-08 | ||
| TRC | C432690-10mg |
Ciclesonide |
126544-47-6 | 10mg |
$ 125.00 | 2023-09-08 | ||
| TRC | C432690-25mg |
Ciclesonide |
126544-47-6 | 25mg |
$287.00 | 2023-05-18 | ||
| TRC | C432690-50mg |
Ciclesonide |
126544-47-6 | 50mg |
$ 517.00 | 2023-09-08 | ||
| TRC | C432690-100mg |
Ciclesonide |
126544-47-6 | 100mg |
$1005.00 | 2023-05-18 | ||
| MedChemExpress | HY-B0625-10mM*1mLinDMSO |
Ciclesonide |
126544-47-6 | 99.89% | 10mM*1mLinDMSO |
￥545 | 2023-07-26 | |
| MedChemExpress | HY-B0625-50mg |
Ciclesonide |
126544-47-6 | 99.93% | 50mg |
￥1440 | 2024-05-25 | |
| MedChemExpress | HY-B0625-100mg |
Ciclesonide |
126544-47-6 | 99.93% | 100mg |
￥2340 | 2024-05-25 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-LI941-25mg |
Ciclesonide |
126544-47-6 | 98+% | 25mg |
1294CNY | 2021-05-07 |
Ciclesonide Suppliers
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier
(CAS:126544-47-6)Ciclesonide
Order Number:sfd22499
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:39
Price ($):discuss personally
Email:[email protected]
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier
(CAS:126544-47-6)Ciclesonide
Order Number:LE12359
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:07
Price ($):discuss personally
Email:[email protected]
Ciclesonide Related Literature
-
Lina Zhou,Qiuxiang Yin,Shichao Du,Hongxun Hao,Yanfeng Li,Mingyan Liu,Baohong Hou RSC Adv. 2016 6 51037
-
Ayman Abo Elmaaty,Radwan Alnajjar,Mohammed I. A. Hamed,Muhammad Khattab,Mohamed M. Khalifa,Ahmed A. Al-Karmalawy RSC Adv. 2021 11 10027
-
Zengrui Wu,Hui Ma,Zehui Liu,Lulu Zheng,Zhuohang Yu,Shuying Cao,Wenqing Fang,Lili Wu,Weihua Li,Guixia Liu,Jin Huang,Yun Tang Chem. Sci. 2022 13 1060
-
Zhi Tang,Qiutao Jiang,Lifen Peng,Xinhua Xu,Jie Li,Renhua Qiu,Chak-Tong Au Green Chem. 2017 19 5396
-
Eugene N. Muratov,Rommie Amaro,Carolina H. Andrade,Nathan Brown,Sean Ekins,Denis Fourches,Olexandr Isayev,Dima Kozakov,José L. Medina-Franco,Kenneth M. Merz,Tudor I. Oprea,Vladimir Poroikov,Gisbert Schneider,Matthew H. Todd,Alexandre Varnek,David A. Winkler,Alexey V. Zakharov,Artem Cherkasov,Alexander Tropsha Chem. Soc. Rev. 2021 50 9121
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