• 1. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 2. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 3. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
  Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
• 4. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 5. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazolecarboxylic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazoles Thiazolecarboxylic acids and derivatives

Comprehensive Overview of Ethyl 2-(piperidin-1-yl)thiazole-4-carboxylate (CAS No. 126533-98-0)

Ethyl 2-(piperidin-1-yl)thiazole-4-carboxylate (CAS No. 126533-98-0) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This compound, characterized by its unique thiazole and piperidine moieties, serves as a versatile intermediate in the synthesis of bioactive molecules. Its molecular structure, combining an ethyl carboxylate group with a piperidine-substituted thiazole, makes it a valuable building block for drug discovery and material science applications.

In recent years, the demand for heterocyclic compounds like Ethyl 2-(piperidin-1-yl)thiazole-4-carboxylate has surged due to their role in developing novel therapeutics. Researchers are particularly interested in its potential applications in central nervous system (CNS) drug development, given the piperidine ring's prevalence in neuroactive compounds. The thiazole core, known for its antimicrobial and anti-inflammatory properties, further enhances its appeal for medicinal chemistry projects.

From a synthetic perspective, CAS No. 126533-98-0 is often utilized in multicomponent reactions (MCRs) and catalyzed cross-coupling processes. Its reactivity stems from the electron-rich thiazole ring and the nucleophilic piperidine nitrogen, enabling diverse functionalization. This adaptability aligns with the growing trend of green chemistry, where efficient, atom-economical syntheses are prioritized. Laboratories focusing on sustainable synthesis frequently explore derivatives of this compound to minimize waste and energy consumption.

The compound's physicochemical properties, such as its moderate lipophilicity and hydrogen-bonding capacity, make it a candidate for drug delivery optimization. These traits are critical in addressing contemporary challenges like bioavailability enhancement and blood-brain barrier penetration—topics frequently searched in pharmacokinetic studies. Additionally, its stability under physiological conditions has prompted investigations into its use as a probe molecule in diagnostic assays.

Beyond pharmaceuticals, Ethyl 2-(piperidin-1-yl)thiazole-4-carboxylate finds niche applications in material science, particularly in designing organic semiconductors and ligands for catalysis. The conjugated thiazole system contributes to electron delocalization, a property exploited in optoelectronic devices. This intersection of chemistry and materials engineering reflects the broader convergence of disciplines in modern research.

Quality control of CAS No. 126533-98-0 involves advanced analytical techniques like HPLC-MS and NMR spectroscopy, ensuring high purity for research-grade applications. Suppliers and manufacturers emphasize batch-to-batch consistency, a key concern for laboratories requiring reproducible results. Discussions on analytical method validation for such compounds often dominate forums on laboratory best practices.

In summary, Ethyl 2-(piperidin-1-yl)thiazole-4-carboxylate exemplifies the innovation driving modern synthetic chemistry. Its multifaceted utility—from drug discovery to advanced materials—positions it as a compound of enduring relevance. As interdisciplinary research expands, so too will the applications of this structurally intriguing molecule.

• 105653-53-0(4-Thiazolecarboxylic acid, 2-(1-piperazinyl)-, ethyl ester,dihydrochloride)
• 126534-22-3(4-Thiazolecarboxylic acid, 2-(diethylamino)-, ethyl ester)
• 874536-52-4(4-Thiazolecarboxylic acid, 2-(4-piperidinylamino)-, ethyl ester,monohydrobromide)
• 126533-95-7(Ethyl 2-Morpholino-1,3-thiazole-4-carboxylate)
• 921076-45-1(Sodium 2-pyrrolidin-1-yl-1,3-thiazole-4-carboxylate)
• 429668-06-4
• 1476847-61-6(methyl 2-morpholinothiazole-4-carboxylate)
• 104481-24-5(ethyl 2-(piperazin-1-yl)-1,3-thiazole-4-carboxylate)
• 952182-68-2(2-(Piperidin-1-yl)thiazole-4-carboxylic acid)
• 429668-04-2