Cas no 126325-47-1 (6-Bromo-2-methylpyridin-3-amine)

6-Bromo-2-methylpyridin-3-amine is a brominated pyridine derivative featuring an amine functional group at the 3-position and a methyl substituent at the 2-position. This compound serves as a versatile intermediate in organic synthesis, particularly in pharmaceutical and agrochemical applications. Its bromine moiety enables further functionalization via cross-coupling reactions, while the amine group allows for derivatization into amides, imines, or other nitrogen-containing structures. The methyl group enhances steric and electronic properties, influencing reactivity and selectivity. The compound is characterized by its stability and compatibility with a range of reaction conditions, making it a valuable building block for constructing complex heterocyclic frameworks.
6-Bromo-2-methylpyridin-3-amine structure
126325-47-1 structure
Product Name:6-Bromo-2-methylpyridin-3-amine
CAS No:126325-47-1
MF:C6H7BrN2
MW:187.037180185318
MDL:MFCD03095086
CID:63817
PubChem ID:354333937
Update Time:2025-11-01

6-Bromo-2-methylpyridin-3-amine Chemical and Physical Properties

Names and Identifiers

    • 3-Amino-6-bromo-2-methylpyridine
    • 5-AMINO-2-BROMO-6-METHYLPYRIDINE
    • 3-AMINO-6-BROMO-2-PICOLINE
    • 6-BROMO-2-METHYL-PYRIDIN-3-YLAMINE
    • 2-Bromo-5-amino-6-methylpyridine
    • 6-Bromo-5-amino-2-picoline
    • 6-BROMO-3-AMINO-2-PICOLINE (5-AMINO-2-BROMO-6-PICOLINE)
    • 3-Pyridinamine, 6-bromo-2-methyl-
    • 6-Bromo-2-methylpyridin-3-amine
    • 3-AMINO-2-BROMO-5-METHYLPYRIDINE
    • 5-AMINO-2-BROMO-6-PICOLINE
    • EOS-60356
    • 6-broMo-2-Methyl-3-aMinopyridine
    • 6-bromo-2-methylpyridine-3-amine
    • 2-bromo-5-amino-6-picoline
    • 6-bromo-2-methyl-3-pyridylamine
    • PubChem1117
    • KSC914I1L
    • EBD3255
    • UBTQJSZELCWGCN-UHFFFAOYSA-N
    • 6-bromo-2-methyl-pyridin-3-amine
    • BCP22164
    • 3-amino-6-bromo
    • AM62390
    • 126325-47-1
    • DTXSID80560031
    • (6-Bromo-2-methylpyridin-3-yl)amine
    • AC-6712
    • EN300-85400
    • SCHEMBL1128404
    • SY008963
    • FT-0648073
    • 5-amino-2-bromo-6-picoline, AldrichCPR
    • MFCD03095086
    • BDBM626220
    • 2-METHYL-3-AMINO-6-BROMOPYRIDINE
    • Quinoline, 8-bromo-4-methyl-
    • AKOS006280301
    • PB20014
    • PS-5009
    • W-205240
    • 5-Amino-2-bromo-6-picoline (5-Amino-2-bromo-6-methylpyridine)
    • CS-D0973
    • DB-023715
    • A2928
    • MDL: MFCD03095086
    • Inchi: 1S/C6H7BrN2/c1-4-5(8)2-3-6(7)9-4/h2-3H,8H2,1H3
    • InChI Key: UBTQJSZELCWGCN-UHFFFAOYSA-N
    • SMILES: BrC1=CC=C(C(C)=N1)N

Computed Properties

  • Exact Mass: 185.97900
  • Monoisotopic Mass: 185.97926g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 9
  • Rotatable Bond Count: 0
  • Complexity: 97.1
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 38.9
  • XLogP3: 1.6

Experimental Properties

  • Color/Form: Pale-yellow to Yellow-brown Solid
  • Density: 1.593
  • Melting Point: 108.0 to 112.0 deg-C
  • Boiling Point: 284.4℃ at 760 mmHg
  • Flash Point: 125.8℃
  • Refractive Index: 1.617
  • PSA: 38.91000
  • LogP: 2.31590

6-Bromo-2-methylpyridin-3-amine Security Information

6-Bromo-2-methylpyridin-3-amine Customs Data

  • HS CODE:2933399090
  • Customs Data:

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Additional information on 6-Bromo-2-methylpyridin-3-amine

Comprehensive Overview of 6-Bromo-2-methylpyridin-3-amine (CAS No. 126325-47-1): Properties, Applications, and Industry Insights

6-Bromo-2-methylpyridin-3-amine (CAS No. 126325-47-1) is a specialized heterocyclic compound with a pyridine backbone, widely recognized for its role in pharmaceutical intermediates and agrochemical synthesis. This compound features a bromine substituent at the 6-position and a methyl group at the 2-position, which contribute to its unique reactivity and versatility in organic transformations. Researchers and industries value it for its potential in designing bioactive molecules, particularly in drug discovery and material science.

The growing demand for 6-Bromo-2-methylpyridin-3-amine is driven by its applications in catalysis and cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig couplings. These reactions are pivotal in creating complex organic frameworks for API development (Active Pharmaceutical Ingredients). Recent trends highlight its utility in small-molecule inhibitors targeting kinases, a hot topic in cancer research and precision medicine. Users searching for "pyridine derivatives in drug design" or "brominated amine synthesis" will find this compound highly relevant.

From a synthetic chemistry perspective, CAS No. 126325-47-1 offers excellent regioselectivity, making it a preferred building block for high-value intermediates. Its stability under mild conditions aligns with the industry's shift toward green chemistry and sustainable synthesis. Environmental concerns and regulatory pressures have increased searches for "eco-friendly bromination methods" and "low-toxicity pyridine analogs," positioning this compound as a candidate for innovation.

In material science, 6-Bromo-2-methylpyridin-3-amine contributes to the development of organic semiconductors and ligand systems for metal-organic frameworks (MOFs). These applications resonate with trending topics like "next-gen electronic materials" and "MOFs for carbon capture." Its structural adaptability allows integration into photovoltaic materials, addressing the surge in interest around renewable energy technologies.

Quality control and analytical standards for CAS No. 126325-47-1 are critical, given its use in high-purity applications. Advanced techniques like HPLC and NMR spectroscopy ensure batch consistency, a frequent concern for buyers searching for "certified pyridine derivatives." Suppliers emphasizing GMP compliance and traceability gain traction in B2B markets.

Future prospects for 6-Bromo-2-methylpyridin-3-amine include expanding its role in bioconjugation and proteomics, areas gaining momentum due to advancements in antibody-drug conjugates (ADCs). As AI-driven drug discovery accelerates, queries like "AI-optimized heterocycles" underscore the need for structurally diverse libraries, where this compound excels.

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