• 1. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 4. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
• 5. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182

Comprehensive Overview of 4-[4-(Ethoxycarbonyl)-3-fluorophenyl]-2-nitrobenzoic acid (CAS No. 1261989-46-1)

4-[4-(Ethoxycarbonyl)-3-fluorophenyl]-2-nitrobenzoic acid (CAS No. 1261989-46-1) is a specialized organic compound that has garnered significant attention in the fields of medicinal chemistry and material science. This compound, characterized by its unique nitrobenzoic acid and ethoxycarbonyl-fluorophenyl moieties, serves as a critical intermediate in the synthesis of advanced pharmaceuticals and functional materials. Its molecular structure, which includes a fluorine substituent and a nitro group, contributes to its reactivity and potential applications in drug design and agrochemical development.

The growing interest in 4-[4-(Ethoxycarbonyl)-3-fluorophenyl]-2-nitrobenzoic acid is driven by its versatility in chemical transformations. Researchers are particularly intrigued by its role in the development of targeted drug delivery systems and bioactive molecules. With the rise of personalized medicine and the demand for highly selective therapeutic agents, this compound has become a focal point in the synthesis of novel small-molecule inhibitors and enzyme modulators. Its fluorinated aromatic ring enhances metabolic stability, making it a valuable building block in modern drug discovery.

In addition to its pharmaceutical applications, CAS No. 1261989-46-1 is also explored in material science for its potential in creating advanced polymers and photoactive materials. The nitro group in its structure allows for further functionalization, enabling the design of materials with tailored optical and electronic properties. This aligns with the current trend of developing sustainable materials and green chemistry solutions, as researchers seek eco-friendly alternatives for industrial processes.

One of the most frequently asked questions about 4-[4-(Ethoxycarbonyl)-3-fluorophenyl]-2-nitrobenzoic acid revolves around its synthesis and purification methods. Optimizing the yield and purity of this compound is critical for its application in high-value industries. Advanced techniques such as HPLC purification and crystallization are often employed to ensure its quality. Furthermore, its stability under various conditions is a topic of ongoing research, particularly for those interested in long-term storage and scalable production.

The compound's relevance extends to the field of agrochemicals, where its derivatives are investigated for their potential as herbicides and pesticides. The fluorine atom in its structure is known to enhance the bioavailability and efficacy of agrochemical agents, addressing the global demand for crop protection solutions. This aligns with the broader industry focus on sustainable agriculture and food security, making CAS No. 1261989-46-1 a compound of strategic importance.

From an environmental perspective, the biodegradability and ecological impact of 4-[4-(Ethoxycarbonyl)-3-fluorophenyl]-2-nitrobenzoic acid are subjects of active investigation. As regulatory frameworks tighten around chemical safety and environmental compliance, understanding the compound's lifecycle and degradation pathways is essential. This is particularly relevant for industries aiming to meet REACH and EPA guidelines while minimizing their ecological footprint.

In summary, 4-[4-(Ethoxycarbonyl)-3-fluorophenyl]-2-nitrobenzoic acid (CAS No. 1261989-46-1) is a multifaceted compound with applications spanning pharmaceuticals, materials science, and agrochemicals. Its unique structural features, including the nitrobenzoic acid core and fluorophenyl group, make it a valuable asset in research and industrial settings. As the scientific community continues to explore its potential, this compound is poised to play a pivotal role in addressing some of the most pressing challenges in healthcare, agriculture, and sustainable technology.

• 2248-38-6(3-Fluoro-4-methyl-5-nitro-benzoic acid, ethyl ester)
• 1154426-16-0(Ethyl 2-fluoro-6-nitrobenzoate)
• 212189-78-1(Methyl 2-fluoro-6-nitrobenzoate)
• 1261904-25-9(4-(4-Carboxy-3-fluorophenyl)-2-nitrobenzoic acid)
• 212189-28-1(Benzenamine,4-[(1-naphthalenyloxy)methyl]-)
• 1261908-45-5(4-(3-Fluoro-5-methoxycarbonylphenyl)-2-nitrobenzoic acid)
• 1261912-35-9(4-(2-Fluoro-5-methoxycarbonylphenyl)-2-nitrobenzoic acid)
• 1261916-41-9(4-(2-Fluoro-4-methoxycarbonylphenyl)-2-nitrobenzoic acid)
• 1261935-26-5(3-[4-(Ethoxycarbonyl)-3-fluorophenyl]-5-nitrobenzoic acid)
• 753924-48-0(Methyl 2-fluoro-4-methyl-5-nitrobenzoate)