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Comprehensive Guide to 3-amino-5-(3,5-dimethylphenyl)benzoic Acid (CAS No. 1261971-18-9): Properties, Applications, and Market Insights

3-amino-5-(3,5-dimethylphenyl)benzoic Acid (CAS No. 1261971-18-9) is a specialized organic compound that has garnered significant attention in pharmaceutical and materials science research. This benzoic acid derivative features a unique molecular structure with an amino group at the 3-position and a dimethylphenyl substituent at the 5-position, making it a valuable intermediate for various synthetic applications. The compound's molecular formula is C₁₅H₁₅NO₂, with a molecular weight of 241.29 g/mol, and it typically appears as a white to off-white crystalline powder.

The growing interest in 3-amino-5-(3,5-dimethylphenyl)benzoic Acid stems from its versatile applications in medicinal chemistry. Researchers are particularly interested in its potential as a building block for small molecule drug discovery, especially in the development of kinase inhibitors and other targeted therapies. The presence of both amino and carboxylic acid functional groups allows for diverse chemical modifications, making this compound a flexible scaffold for structure-activity relationship (SAR) studies. Recent publications have highlighted its use in developing compounds with potential anti-inflammatory and anticancer properties.

From a synthetic chemistry perspective, 3-amino-5-(3,5-dimethylphenyl)benzoic Acid offers several advantages. The electron-donating dimethyl groups on the phenyl ring influence the compound's electronic properties, while the amino and carboxyl groups provide handles for further functionalization. This makes it particularly valuable for creating pharmaceutical intermediates with improved solubility and bioavailability profiles. The compound's stability under various conditions also contributes to its utility in multi-step synthetic routes.

The market for 3-amino-5-(3,5-dimethylphenyl)benzoic Acid has seen steady growth, driven by increasing demand from contract research organizations (CROs) and pharmaceutical companies engaged in drug discovery programs. Suppliers typically offer this compound with high purity (≥98%) for research purposes, with pricing reflecting its specialized nature. Current research trends suggest expanding applications in materials science, particularly in the development of organic semiconductors and advanced polymers, where its conjugated system and functional groups could prove valuable.

Quality control for 3-amino-5-(3,5-dimethylphenyl)benzoic Acid typically involves HPLC analysis, mass spectrometry, and NMR spectroscopy to verify purity and structural integrity. Storage recommendations generally suggest keeping the compound in a cool, dry place, protected from light, to maintain stability. Researchers working with this material should follow standard laboratory safety protocols, including the use of personal protective equipment, although it is not classified as highly hazardous under normal handling conditions.

Recent advancements in synthetic methodology have improved the accessibility of 3-amino-5-(3,5-dimethylphenyl)benzoic Acid, with several published routes offering good yields and scalability. These developments have made the compound more available to the research community, supporting its growing applications. The pharmaceutical industry's continued focus on targeted therapies and personalized medicine suggests that demand for specialized building blocks like this will likely increase in coming years.

For researchers considering 3-amino-5-(3,5-dimethylphenyl)benzoic Acid for their projects, it's important to note that the compound's properties can be fine-tuned through various synthetic modifications. The amino group can participate in amide bond formation or be converted to other nitrogen-containing functionalities, while the carboxylic acid offers opportunities for esterification or conversion to acid chlorides. This versatility makes it particularly valuable for medicinal chemistry programs aiming to explore diverse chemical space.

The future outlook for 3-amino-5-(3,5-dimethylphenyl)benzoic Acid appears promising, with potential applications extending beyond its current uses. As computational chemistry and AI-driven drug discovery methods continue to advance, the demand for well-characterized, versatile building blocks like this compound is expected to grow. Researchers are encouraged to explore its potential in developing novel therapeutic agents and functional materials that could address unmet medical and technological needs.

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