• 1. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 2. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
• 3. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 4. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 5. An apparatus for testing water by measurement of its electrical conductivity
  Analyst, 1912,37, 538-543

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives

Recent Advances in the Study of 2-(4-ethylphenyl)-5-methylbenzoic Acid (CAS: 1261954-71-5)

2-(4-ethylphenyl)-5-methylbenzoic Acid (CAS: 1261954-71-5) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its potential therapeutic applications. This compound, characterized by its unique benzoic acid derivative structure, has been the subject of multiple studies aimed at elucidating its pharmacological properties, mechanism of action, and potential as a drug candidate. The following sections provide a comprehensive overview of the latest research findings related to this compound.

Recent studies have focused on the synthesis and optimization of 2-(4-ethylphenyl)-5-methylbenzoic Acid to enhance its bioavailability and therapeutic efficacy. Researchers have employed advanced synthetic techniques, including multi-step organic synthesis and computational modeling, to modify the compound's structure while preserving its core pharmacophore. These efforts have yielded promising results, with several derivatives exhibiting improved solubility and metabolic stability compared to the parent compound.

In vitro and in vivo studies have demonstrated that 2-(4-ethylphenyl)-5-methylbenzoic Acid exhibits potent anti-inflammatory and analgesic properties. Mechanistic investigations reveal that the compound acts as a selective inhibitor of cyclooxygenase-2 (COX-2), a key enzyme involved in the inflammatory response. This selectivity is particularly noteworthy, as it suggests a reduced risk of gastrointestinal side effects commonly associated with non-selective COX inhibitors. Furthermore, the compound has shown efficacy in animal models of chronic pain, highlighting its potential as a novel analgesic agent.

Beyond its anti-inflammatory effects, recent research has explored the compound's potential in oncology. Preliminary data indicate that 2-(4-ethylphenyl)-5-methylbenzoic Acid may inhibit the proliferation of certain cancer cell lines by modulating signaling pathways involved in cell cycle regulation and apoptosis. These findings have spurred further investigation into its utility as an adjunct therapy in combination with existing chemotherapeutic agents.

Despite these promising results, challenges remain in the development of 2-(4-ethylphenyl)-5-methylbenzoic Acid as a therapeutic agent. Pharmacokinetic studies have identified areas for improvement, particularly in terms of oral bioavailability and half-life. Researchers are currently exploring various formulation strategies, including nanoparticle-based delivery systems, to address these limitations and enhance the compound's clinical applicability.

In conclusion, 2-(4-ethylphenyl)-5-methylbenzoic Acid (CAS: 1261954-71-5) represents a compelling area of research in chemical biology and drug development. Its dual anti-inflammatory and potential anticancer properties, coupled with its selective mechanism of action, make it a promising candidate for further investigation. Ongoing studies are expected to provide deeper insights into its therapeutic potential and pave the way for future clinical applications.

• 537713-32-9([1,1-Biphenyl]-2-carboxylicacid,4-ethyl-(9CI))
• 408367-33-9(2-(3-Acetylphenyl)benzoic acid)
• 500905-09-9([1,1-Biphenyl]-2-carboxylicacid,3-ethyl-(9CI))
• 6276-03-5(1-Fluorenecarboxylic Acid)
• 6954-55-8(9H-fluorene-4-carboxylic acid)
• 108478-11-1(3-Ethyl-[1,1'-biphenyl]-4-carboxylic acid)
• 84392-26-7(2-(4-t-Butylphenyl)benzoic acid)
• 82617-43-4([1,1'-Biphenyl]-3-carboxylic acid, 2-ethyl-)
• 7509-70-8( )
• 84392-25-6(4-Isopropyl-[1,1'-biphenyl]-2-carboxylic acid)