Cas no 1261935-27-6 (2-fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic Acid)

2-Fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic acid is a fluorinated aromatic carboxylic acid derivative with a distinct substitution pattern, featuring fluoro and methoxy functional groups on adjacent phenyl rings. This compound is of interest in pharmaceutical and agrochemical research due to its potential as a versatile intermediate in the synthesis of bioactive molecules. The presence of fluorine atoms enhances metabolic stability and binding affinity, while the methoxy group offers opportunities for further functionalization. Its well-defined structure and high purity make it suitable for applications in medicinal chemistry, particularly in the development of enzyme inhibitors or receptor modulators. The compound’s stability under standard conditions ensures reliable handling and storage.
2-fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic Acid structure
1261935-27-6 structure
Product Name:2-fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic Acid
CAS No:1261935-27-6
MF:C14H10F2O3
MW:264.224211215973
MDL:MFCD18320558
CID:1219343
PubChem ID:53226460
Update Time:2025-06-13

2-fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic Acid Chemical and Physical Properties

Names and Identifiers

    • 2-fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic Acid
    • DTXSID70690078
    • 1261935-27-6
    • MFCD18320558
    • AKOS017552374
    • 2-Fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic acid, 95%
    • 2',4-Difluoro-3'-methoxy[1,1'-biphenyl]-3-carboxylic acid
    • MDL： MFCD18320558
    • Inchi： 1S/C14H10F2O3/c1-19-12-4-2-3-9(13(12)16)8-5-6-11(15)10(7-8)14(17)18/h2-7H,1H3,(H,17,18)
    • InChI Key： QQBRDTDEHBQROL-UHFFFAOYSA-N
    • SMILES： FC1C(=CC=CC=1C1C=CC(=C(C(=O)O)C=1)F)OC

Computed Properties

  • Exact Mass: 264.05980050g/mol
  • Monoisotopic Mass: 264.05980050g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 19
  • Rotatable Bond Count: 3
  • Complexity: 324
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.2
  • Topological Polar Surface Area: 46.5?2

2-fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic Acid Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
abcr
AB327738-5g
2-Fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic acid, 95%; .
 1261935-27-6 95%
5g
 €1159.00 2025-04-21
abcr
AB327738-5 g
2-Fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic acid, 95%; .
 1261935-27-6 95%
5g
 €1159.00 2023-04-26

2-fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic Acid Related Literature

Additional information on 2-fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic Acid

Comprehensive Overview of 2-Fluoro-5-(2-Fluoro-3-Methoxyphenyl)Benzoic Acid (CAS No. 1261935-27-6)

2-Fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic acid (CAS 1261935-27-6) is a fluorinated aromatic carboxylic acid derivative with significant potential in pharmaceutical and agrochemical research. This compound features a unique bis-fluorinated structure combined with a methoxy substituent, making it a valuable intermediate for drug discovery and material science applications. Its molecular formula, C14H10F2O3, highlights its moderate polarity, which is critical for solubility optimization in medicinal chemistry.

Recent trends in AI-driven drug design and green chemistry have amplified interest in fluorinated compounds like 2-fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic acid. Researchers frequently search for "fluorinated benzoic acid derivatives" or "CAS 1261935-27-6 applications" to explore its role in kinase inhibitor synthesis or biodegradable polymer development. The compound’s meta-substitution pattern and electron-withdrawing properties are particularly relevant for modulating biological activity, a topic widely discussed in SAR (Structure-Activity Relationship) studies.

From a synthetic perspective, 1261935-27-6 is often prepared via Suzuki-Miyaura cross-coupling or nucleophilic aromatic substitution, methods trending in "sustainable catalysis" queries. Its logP value (predicted ~2.8) aligns with Lipinski’s Rule of Five, addressing frequent search terms like "drug-likeness of fluorinated aromatics." Analytical techniques such as HPLC-MS and NMR are essential for purity verification, reflecting lab professionals’ searches for "CAS 1261935-27-6 characterization."

The compound’s thermal stability (decomposition >250°C) and photostability make it suitable for "high-performance material" applications, a hotspot in nanotechnology forums. Environmental scientists also investigate its "biodegradation pathways," given increasing regulatory focus on PFAS alternatives. Notably, its low acute toxicity (per preliminary assays) positions it favorably against traditional halogenated analogs.

In conclusion, 2-fluoro-5-(2-fluoro-3-methoxyphenyl)benzoic acid exemplifies the convergence of medicinal chemistry and materials innovation. Its dual fluorine atoms and methoxy group offer tunable reactivity, addressing trending queries like "multifunctional building blocks" and "eco-friendly fluorophores." As research progresses, this compound is poised to play a pivotal role in next-generation therapeutics and smart materials.

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