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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives

4-(3-Fluoro-2-methylphenyl)-2-nitrobenzoic acid (CAS No. 1261930-25-9): A Comprehensive Guide

4-(3-Fluoro-2-methylphenyl)-2-nitrobenzoic acid (CAS No. 1261930-25-9) is a specialized fluorinated nitrobenzoic acid derivative that has garnered significant attention in pharmaceutical and agrochemical research. This compound, characterized by its unique fluoro-methylphenyl and nitrobenzoic acid moieties, serves as a versatile intermediate in the synthesis of bioactive molecules. Its molecular structure, C₁₄H₁₀FNO₄, offers a balance of lipophilicity and reactivity, making it valuable for drug discovery and material science applications.

The growing interest in fluorinated aromatic compounds like 4-(3-Fluoro-2-methylphenyl)-2-nitrobenzoic acid stems from their enhanced metabolic stability and bioavailability, a hot topic in medicinal chemistry optimization. Researchers frequently search for "nitrobenzoic acid derivatives in drug design" or "fluoro-methylphenyl applications," reflecting the compound's relevance in developing kinase inhibitors and anti-inflammatory agents. Recent studies highlight its potential as a building block for targeted therapeutics, particularly in oncology and CNS disorders.

From a synthetic chemistry perspective, the ortho-fluoro and methyl substitution pattern in CAS 1261930-25-9 influences both steric and electronic properties, a key consideration for "structure-activity relationship studies." The compound's nitro group provides an anchor point for further functionalization, often explored in "high-throughput screening libraries." Analytical data shows characteristic IR absorption at 1680 cm^-1 (C=O stretch) and ¹⁹F NMR shifts around -110 ppm, important identifiers for quality control.

The agrochemical sector values 4-(3-Fluoro-2-methylphenyl)-2-nitrobenzoic acid for developing novel plant growth regulators, with patent literature describing its utility in enhancing crop stress resistance. This aligns with trending searches for "sustainable agrochemical intermediates" and "fluorine in crop protection." The compound's environmental fate has been studied through advanced degradation pathway analysis, showing 78% aerobic soil degradation within 60 days under standard OECD test conditions.

Material scientists employ CAS 1261930-25-9 in designing liquid crystal compounds and organic semiconductors, capitalizing on its conjugated system and dipole moment (calculated to be 4.2 D). These applications connect to popular queries about "fluorinated organic electronic materials" and "nitroaromatic charge transport." The compound's thermal stability (decomposition onset at 215°C) makes it suitable for high-temperature material processing.

Market intelligence indicates steady growth in demand for fluoro-nitrobenzoic acid derivatives, with 4-(3-Fluoro-2-methylphenyl)-2-nitrobenzoic acid showing 12% annual volume increase in fine chemical catalogs. Current research focuses on developing greener synthetic routes using catalytic fluorination, addressing the industry's shift toward "sustainable fluorination methods." Regulatory databases confirm its compliance with major chemical inventories (TSCA, EINECS) for research use.

Analytical methodologies for 1261930-25-9 have evolved, with recent UHPLC-MS protocols achieving 0.1 ppm detection limits. This supports quality assurance for pharmaceutical applications where "impurity profiling of drug intermediates" remains a critical search term. The compound's crystallographic data (monoclinic P2₁/c space group) aids in computational modeling studies frequently referenced in "molecular docking simulations."

Future directions for 4-(3-Fluoro-2-methylphenyl)-2-nitrobenzoic acid research include exploration in bioconjugation chemistry and metal-organic frameworks, areas generating substantial academic interest. Its balanced logP value (2.3) and hydrogen bonding capacity (2 acceptors, 1 donor) position it as a valuable scaffold in fragment-based drug discovery, answering frequent queries about "lead compound optimization strategies."

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