• 1. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 2. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 3. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 4. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 5. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives

Comprehensive Analysis of 3-(2,6-Difluorophenyl)phenol (CAS No. 1261910-30-8): Properties, Applications, and Industry Trends

3-(2,6-Difluorophenyl)phenol (CAS No. 1261910-30-8) is a fluorinated aromatic compound that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural properties. As a difluorophenyl-substituted phenol, this compound exhibits enhanced stability and reactivity compared to non-fluorinated analogs, making it a valuable intermediate in synthetic chemistry. The presence of ortho-fluorine atoms on the phenyl ring introduces steric and electronic effects that influence its molecular interactions, a feature increasingly exploited in drug design.

Recent studies highlight the growing demand for fluorinated building blocks like 3-(2,6-difluorophenyl)phenol in the development of small-molecule therapeutics. Its CAS registry number (1261910-30-8) frequently appears in patent literature for kinase inhibitors and antimicrobial agents. The compound's lipophilicity-enhancing fluorine atoms align with current trends in bioavailability optimization, addressing a key challenge in modern drug discovery. Researchers also investigate its potential in crop protection chemicals, where fluorinated phenols demonstrate improved pest resistance profiles.

The synthesis of 3-(2,6-difluorophenyl)phenol typically involves palladium-catalyzed cross-coupling between fluorinated aryl halides and phenolic derivatives. This methodology reflects the broader shift toward transition metal-catalyzed reactions in industrial-scale production. Analytical characterization via HPLC-MS and NMR spectroscopy confirms the high purity (>98%) required for pharmaceutical applications. Notably, the compound's thermal stability (decomposition point >200°C) makes it suitable for high-temperature processes.

Environmental considerations surrounding fluorinated organic compounds have prompted innovations in the sustainable manufacturing of 3-(2,6-difluorophenyl)phenol. Green chemistry approaches utilizing biocatalysts and flow reactor technology are being explored to reduce waste generation. These advancements respond to industry demands for eco-friendly synthetic routes while maintaining cost-efficiency – a balance frequently searched by chemical engineers in process optimization queries.

Market analyses indicate rising procurement of 1261910-30-8 by contract research organizations (CROs) specializing in fluorine chemistry. The compound's compatibility with late-stage fluorination techniques positions it as a strategic material for structure-activity relationship (SAR) studies. Regulatory databases show increasing REACH compliance documentation for this substance, reflecting its transition from research-scale to commercial applications.

In material science, derivatives of 3-(2,6-difluorophenyl)phenol demonstrate promise as monomers for high-performance polymers. The electron-withdrawing fluorine substituents improve thermal oxidative stability in polyaryletherketones (PAEKs), a property highly sought after in aerospace composites and electronic encapsulation materials. This multidisciplinary applicability contributes to its growing presence in scientific literature across 15+ Scopus-indexed journals annually.

Quality control protocols for CAS 1261910-30-8 emphasize rigorous impurity profiling, particularly for residual catalyst detection. Advanced techniques like ICP-MS ensure compliance with stringent ICH guidelines for pharmaceutical intermediates. Storage recommendations typically specify argon-protected conditions to prevent oxidative degradation, a detail often queried by laboratory managers in chemical handling forums.

The future trajectory of 3-(2,6-difluorophenyl)phenol research appears closely tied to developments in precision fluorination methodologies. With over 120 recent patent citations referencing this compound, its role in next-generation drug candidates continues to expand. Ongoing investigations explore its utility in PET radiotracer synthesis and liquid crystal formulations, demonstrating the remarkable versatility of this fluorinated phenolic compound.

• 84145-01-7([1,1'-Biphenyl]-4-ol,2',4'-difluoro-, sodium salt (1:1))
• 1261889-63-7(3-(2,5-Difluorophenyl)phenol)
• 406482-53-9(3-fluoro-4-(3-hydroxyphenyl)phenol)
• 1261899-97-1(3-(2,4,6-Trifluorophenyl)phenol)
• 1261893-14-4((1,1'-Biphenyl)-3-ol, 2'-fluoro-5-methyl-)
• 628306-32-1(4-(2,6-Difluorophenyl)phenol)
• 656304-26-6(3-(2,4-Difluorophenyl)phenol)
• 1261888-31-6(5-(2-Fluoro-4-methylphenyl)-3-methylphenol)
• 59089-68-8(2',4'-Difluorobiphenyl-4-ol)
• 80254-63-3(3-(2-Fluorophenyl)phenol)