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  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 2. An analyte-triggered artificial peroxidase system based on dimanganese complex for a versatile enzyme assay?
  Suji Lee,Min Su Han Chem. Commun., 2021,57, 9450-9453
• 3. An intermolecular C–C coupling reaction of iridium complexes?
  Kathrin Kutlescha,Rhett Kempe New J. Chem., 2010,34, 1954-1960
• 4. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644
• 5. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
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Comprehensive Analysis of 2-Chloro-4-(4-methoxycarbonylphenyl)phenol (CAS No. 1261899-32-4): Properties, Applications, and Industry Trends

2-Chloro-4-(4-methoxycarbonylphenyl)phenol (CAS 1261899-32-4) is a specialized organic compound gaining attention in pharmaceutical intermediates and advanced material synthesis. With the molecular formula C₁₄H₁₁ClO₃, this chlorinated phenolic derivative features a unique combination of methoxycarbonyl and hydroxyl functional groups, enabling versatile reactivity. Recent PubMed studies highlight its potential as a building block for non-steroidal anti-inflammatory drug (NSAID) analogs, aligning with the growing demand for novel anti-inflammatory agents in precision medicine.

The compound's structure-activity relationship (SAR) has become a focal point in 2024 research, particularly for designing targeted kinase inhibitors. Its electron-withdrawing chloro group and planar aromatic system facilitate π-π stacking interactions crucial in protein-ligand binding – a hot topic in AI-driven drug discovery platforms. Analytical data from Reaxys indicates 89% purity in commercial samples, with characteristic IR peaks at 1685 cm^-1 (ester C=O) and 3250 cm^-1 (phenolic OH), making it identifiable via spectroscopic fingerprinting techniques increasingly used in quality-by-design (QbD) pharmaceutical manufacturing.

Environmental considerations position 2-Chloro-4-(4-methoxycarbonylphenyl)phenol as a low-PBT (persistent, bioaccumulative, toxic) substance according to ECHA guidelines. Its biodegradation half-life of 28 days (OECD 301F) addresses sustainability concerns in green chemistry applications. The compound's logP value of 3.1 suggests moderate lipophilicity, optimal for drug permeability – a key parameter in bioavailability enhancement strategies trending in formulation science.

Industrial applications leverage its photostability (Δλ_max < 5nm after 300h UV exposure) for advanced polymer additives. Patent analysis reveals 23% annual growth in its use for high-performance polycarbonate modifications, particularly in optical materials for AR/VR devices. The methoxycarbonyl moiety enables facile cross-coupling reactions, with 72% yield reported in Suzuki-Miyaura reactions (ACS Catal. 2023) – a technique dominating C-C bond formation discussions in synthetic chemistry forums.

Quality standards for CAS 1261899-32-4 now include ICH Q3D elemental impurity limits, reflecting heightened regulatory focus on metal catalyst residues. Chromatographic methods (HPLC-UV at 254nm) achieve 0.1% impurity detection, critical for GMP-compliant production. The compound's thermal stability (decomposition >210°C) supports its use in high-temperature synthesis processes, a trending topic in flow chemistry optimization for scale-up.

Emerging research explores its antioxidant capacity (IC₅₀ 18μM in DPPH assays), relevant to cosmeceutical preservative systems – a market projected to grow at 7.2% CAGR through 2030. The ortho-chloro substitution pattern shows unique hydrogen bonding behavior in cocrystal engineering, an area gaining traction in solid-state pharmaceutical development. Computational studies (DFT at B3LYP/6-31G*) predict its molecular electrostatic potential aligns with enzyme active sites, supporting rational drug design approaches.

Supply chain data indicates 94% availability from specialty chemical distributors, with pricing stability (±5% since 2022) despite global raw material fluctuations. Storage recommendations emphasize nitrogen atmosphere protection to maintain oxidative stability, a best practice highlighted in recent chemical storage AI management systems. The compound's water solubility (1.2g/L at 25°C) facilitates aqueous workup procedures preferred in benign solvent initiatives.

Future directions include exploring its electrochemical properties for organic semiconductor applications, with preliminary cyclic voltammetry showing reversible oxidation at +1.2V vs SCE. This aligns with the flexible electronics boom, particularly in wearable sensor development. The regioselective reactivity of its phenolic group also shows promise for site-specific bioconjugation in antibody-drug conjugate (ADC) platforms – a therapeutic area experiencing 34% annual investment growth.

• 17302-82-8(Ethyl 3,5-dichloro-4-hydroxybenzoate)
• 16357-41-8(Ethyl 3-chloro-4-hydroxybenzoate)
• 1198422-80-8(2-Chloro-5-(4-methoxycarbonylphenyl)phenol)
• 287399-19-3(Methyl 3,5-Dichloro-4-Hydroxybenzoate Hydrate)
• 105674-97-3(Benzoic acid, 3-chloro-4-hydroxy-, methyl ester, sodium salt (1:1))
• 335013-90-6(4-Chloro-3-hydroxybenzoic Acid Ethyl Ester)
• 96460-02-5(4-(3-chloro-4-hydroxyphenyl)benzoic acid)
• 3337-59-5(Methyl 3,5-dichloro-4-hydroxybenzoate)
• 3964-57-6(Methyl 3-chloro-4-hydroxybenzoate)
• 166272-81-7(4-Chloro-3-hydroxybenzoic Acid Methyl Ester)