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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives

Comprehensive Guide to 3-(2,4-Dimethoxyphenyl)-5-fluorobenzoic acid (CAS No. 1261895-15-1): Properties, Applications, and Market Insights

3-(2,4-Dimethoxyphenyl)-5-fluorobenzoic acid (CAS No. 1261895-15-1) is a fluorinated benzoic acid derivative with significant potential in pharmaceutical and material science applications. This compound features a unique structural combination of dimethoxyphenyl and fluorobenzoic acid moieties, making it a valuable intermediate for drug discovery and specialty chemicals. Researchers and industry professionals are increasingly interested in this compound due to its versatile reactivity and potential therapeutic applications.

The molecular formula of 3-(2,4-Dimethoxyphenyl)-5-fluorobenzoic acid is C₁₅H₁₃FO₄, with a molecular weight of 276.26 g/mol. Its chemical structure contains two methoxy groups at the 2- and 4-positions of the phenyl ring, along with a fluorine atom at the 5-position of the benzoic acid moiety. This specific arrangement contributes to its distinctive physicochemical properties, including moderate solubility in organic solvents and thermal stability up to 200°C.

In pharmaceutical research, 3-(2,4-Dimethoxyphenyl)-5-fluorobenzoic acid serves as a key building block for developing novel drug candidates. The presence of both fluorine and methoxy groups enhances the compound's ability to interact with biological targets, particularly in central nervous system (CNS) disorders and inflammatory conditions. Recent studies have explored its potential as a precursor for kinase inhibitors and GPCR modulators, aligning with current trends in precision medicine and targeted therapies.

The material science field has also shown growing interest in CAS 1261895-15-1 for developing advanced polymers and liquid crystal materials. The compound's aromatic structure and functional groups enable its incorporation into high-performance polymers with enhanced thermal and mechanical properties. Researchers are investigating its use in creating novel organic electronic materials, responding to the increasing demand for flexible electronics and sustainable materials in the tech industry.

Synthetic approaches to 3-(2,4-Dimethoxyphenyl)-5-fluorobenzoic acid typically involve multi-step organic reactions, including Friedel-Crafts acylation and halogenation processes. Recent advancements in green chemistry have led to more efficient synthetic routes with improved yields and reduced environmental impact. These developments address the pharmaceutical industry's growing emphasis on sustainable manufacturing practices and process optimization.

Market analysis indicates steady growth in demand for fluorinated benzoic acid derivatives, driven by expanding applications in life sciences and specialty chemicals. The global market for such intermediates is projected to grow at a CAGR of 5-7% through 2030, with Asia-Pacific emerging as a key production and consumption region. This growth aligns with increasing investments in pharmaceutical R&D and the expansion of the electronics materials sector.

Quality control and characterization of 3-(2,4-Dimethoxyphenyl)-5-fluorobenzoic acid require advanced analytical techniques, including HPLC, GC-MS, and NMR spectroscopy. The compound typically appears as a white to off-white crystalline powder with purity levels exceeding 98% in commercial samples. Proper storage conditions (room temperature, protected from moisture) ensure long-term stability for research and industrial applications.

Recent patent filings related to CAS 1261895-15-1 demonstrate its growing importance in intellectual property landscapes. Pharmaceutical companies have claimed derivatives of this compound in applications ranging from neurodegenerative disease treatments to novel antimicrobial agents. This patent activity reflects the compound's versatility and the competitive nature of innovation in medicinal chemistry.

Environmental and safety considerations for handling 3-(2,4-Dimethoxyphenyl)-5-fluorobenzoic acid follow standard laboratory protocols for organic compounds. While not classified as highly hazardous, appropriate personal protective equipment (PPE) including gloves and safety glasses is recommended during handling. The compound's environmental fate and toxicity profile are subjects of ongoing research as part of broader chemical safety assessments.

Future research directions for 3-(2,4-Dimethoxyphenyl)-5-fluorobenzoic acid include exploration of its biological activities and material properties. Scientists are particularly interested in its potential as a scaffold for developing new radiopharmaceuticals and as a component in organic photovoltaic materials. These applications align with current trends in personalized medicine and renewable energy technologies.

For researchers and procurement specialists seeking CAS 1261895-15-1, several reputable chemical suppliers offer the compound in various quantities and purity grades. Quality verification through certificates of analysis (CoA) and proper supplier evaluation are essential steps in the procurement process. The compound's pricing reflects its specialized nature and the complexity of its synthesis.

In conclusion, 3-(2,4-Dimethoxyphenyl)-5-fluorobenzoic acid represents an important fluorinated aromatic compound with diverse applications across multiple scientific disciplines. Its unique structural features and reactivity profile continue to attract research attention in both academic and industrial settings. As synthetic methodologies advance and new applications emerge, this compound is poised to play an increasingly significant role in the development of innovative pharmaceuticals and advanced materials.

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