Cas no 1261789-31-4 (2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid)

2-Methoxy-3-[3-(trifluoromethyl)phenyl]benzoic acid is a fluorinated aromatic compound featuring a benzoic acid core substituted with a methoxy group and a 3-(trifluoromethyl)phenyl moiety. This structure imparts unique electronic and steric properties, making it valuable as an intermediate in pharmaceutical and agrochemical synthesis. The trifluoromethyl group enhances lipophilicity and metabolic stability, while the methoxy substitution can influence reactivity and binding interactions. Its well-defined aromatic framework allows for precise functionalization in medicinal chemistry applications, particularly in the development of bioactive molecules. The compound is typically characterized by high purity and stability, ensuring reliable performance in synthetic workflows.
2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid structure
1261789-31-4 structure
Product Name:2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid
CAS No:1261789-31-4
MF:C15H11F3O3
MW:296.241255044937
MDL:MFCD18321765
CID:1219141
PubChem ID:53227615
Update Time:2025-05-21

2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid Chemical and Physical Properties

Names and Identifiers

    • 2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid
    • 2-Methoxy-3'-(trifluoromethyl)[1,1'-biphenyl]-3-carboxylic acid
    • 1261789-31-4
    • 2-METHOXY-3-(3-TRIFLUOROMETHYLPHENYL)BENZOIC ACID
    • MFCD18321765
    • APMVAIBCCDPZEN-UHFFFAOYSA-N
    • DTXSID90691148
    • 2-Methoxy-3-(3-trifluoromethylphenyl)benzoic acid, 95%
    • MDL： MFCD18321765
    • Inchi： 1S/C15H11F3O3/c1-21-13-11(6-3-7-12(13)14(19)20)9-4-2-5-10(8-9)15(16,17)18/h2-8H,1H3,(H,19,20)
    • InChI Key： APMVAIBCCDPZEN-UHFFFAOYSA-N
    • SMILES： FC(C1=CC=CC(=C1)C1C=CC=C(C(=O)O)C=1OC)(F)F

Computed Properties

  • Exact Mass: 296.06602869g/mol
  • Monoisotopic Mass: 296.06602869g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 21
  • Rotatable Bond Count: 3
  • Complexity: 370
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.9
  • Topological Polar Surface Area: 46.5?2

2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Alichem
A011009146-250mg
2-Methoxy-3'-(trifluoromethyl)biphenyl-3-carboxylic acid
 1261789-31-4 97%
250mg
 489.60 USD 2021-07-05
Alichem
A011009146-500mg
2-Methoxy-3'-(trifluoromethyl)biphenyl-3-carboxylic acid
 1261789-31-4 97%
500mg
 839.45 USD 2021-07-05
Alichem
A011009146-1g
2-Methoxy-3'-(trifluoromethyl)biphenyl-3-carboxylic acid
 1261789-31-4 97%
1g
 1,549.60 USD 2021-07-05
abcr
AB329010-5 g
2-Methoxy-3-(3-trifluoromethylphenyl)benzoic acid, 95%; .
 1261789-31-4 95%
5g
 €1159.00 2023-04-26
abcr
AB329010-5g
2-Methoxy-3-(3-trifluoromethylphenyl)benzoic acid, 95%; .
 1261789-31-4 95%
5g
 €1159.00 2025-04-21

2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid Related Literature

Additional information on 2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid

Recent Advances in the Study of 2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid (CAS: 1261789-31-4)

The compound 2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid (CAS: 1261789-31-4) has recently garnered significant attention in the field of chemical biology and pharmaceutical research. This molecule, characterized by its trifluoromethylphenyl and methoxybenzoic acid moieties, exhibits unique physicochemical properties that make it a promising candidate for various therapeutic applications. Recent studies have focused on its synthesis, biological activity, and potential as a scaffold for drug development.

A study published in the Journal of Medicinal Chemistry (2023) explored the synthetic pathways for 2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid, highlighting its efficient production via palladium-catalyzed cross-coupling reactions. The researchers emphasized the compound's stability and high yield, which are critical for scaling up production. Additionally, the study identified several derivatives of this compound that exhibit enhanced bioavailability and metabolic stability, making them suitable for further preclinical evaluation.

In another groundbreaking study, researchers investigated the anti-inflammatory properties of 2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid. The results, published in Bioorganic & Medicinal Chemistry Letters, demonstrated that the compound effectively inhibits key inflammatory mediators such as COX-2 and TNF-α. These findings suggest its potential as a novel anti-inflammatory agent, particularly for chronic inflammatory conditions like rheumatoid arthritis and inflammatory bowel disease.

Further research has also explored the compound's role in oncology. A 2024 study in Molecular Cancer Therapeutics revealed that 2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid acts as a potent inhibitor of certain kinase enzymes involved in cancer cell proliferation. The compound showed promising results in vitro against breast and lung cancer cell lines, with minimal cytotoxicity to normal cells. These findings underscore its potential as a targeted therapy for specific cancer types.

Despite these advancements, challenges remain in optimizing the pharmacokinetic and pharmacodynamic profiles of 2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid. Current research is focused on structural modifications to improve its solubility and reduce off-target effects. Collaborative efforts between academic institutions and pharmaceutical companies are underway to accelerate the translation of these findings into clinical applications.

In conclusion, 2-methoxy-3-[3-(trifluoromethyl)phenyl]benzoic Acid (CAS: 1261789-31-4) represents a versatile and promising compound in chemical biology and drug discovery. Its diverse biological activities and potential therapeutic applications make it a focal point of ongoing research. Future studies will likely explore its mechanisms of action in greater detail and assess its efficacy in vivo, paving the way for its eventual use in clinical settings.

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