Cas no 1261736-99-5 (5-Chloro-2-(difluoromethoxy)phenol)

5-Chloro-2-(difluoromethoxy)phenol is a halogenated phenolic compound featuring a difluoromethoxy substituent, which enhances its stability and reactivity in synthetic applications. The chloro and difluoromethoxy groups contribute to its utility as an intermediate in pharmaceuticals and agrochemicals, particularly in the synthesis of active ingredients requiring electron-withdrawing properties. Its structural features promote selective reactivity in electrophilic aromatic substitution and coupling reactions. The compound’s stability under various conditions makes it suitable for multi-step synthetic processes. Careful handling is advised due to potential sensitivity to moisture and light. Analytical methods such as HPLC and NMR confirm high purity, ensuring consistency for research and industrial use.
5-Chloro-2-(difluoromethoxy)phenol structure
1261736-99-5 structure
Product Name:5-Chloro-2-(difluoromethoxy)phenol
CAS No:1261736-99-5
MF:C7H5ClF2O2
MW:194.563208341599
MDL:MFCD18392685
CID:4989284
PubChem ID:86762177
Update Time:2025-06-13

5-Chloro-2-(difluoromethoxy)phenol Chemical and Physical Properties

Names and Identifiers

    • 5-chloro-2-(difluoromethoxy)phenol
    • 5-chloro-2-difluoromethoxyphenol
    • 5-Chloro-2-(difluoromethoxy)phenol
    • MDL: MFCD18392685
    • Inchi: 1S/C7H5ClF2O2/c8-4-1-2-6(5(11)3-4)12-7(9)10/h1-3,7,11H
    • InChI Key: NVFAUUQCOJCGBQ-UHFFFAOYSA-N
    • SMILES: ClC1C=CC(=C(C=1)O)OC(F)F

Computed Properties

  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 2
  • Complexity: 145
  • XLogP3: 3.1
  • Topological Polar Surface Area: 29.5

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Additional information on 5-Chloro-2-(difluoromethoxy)phenol

5-Chloro-2-(difluoromethoxy)phenol (CAS No. 1261736-99-5): A Comprehensive Overview

5-Chloro-2-(difluoromethoxy)phenol (CAS No. 1261736-99-5) is a specialized organic compound that has garnered significant attention in recent years due to its unique chemical properties and potential applications. This compound, often referred to by its systematic name or abbreviated as 5-Chloro-DFMP, belongs to the class of halogenated phenols, which are widely studied for their versatility in synthetic chemistry and industrial applications. The presence of both chloro and difluoromethoxy functional groups in its structure makes it a valuable intermediate in the development of pharmaceuticals, agrochemicals, and advanced materials.

The growing interest in 5-Chloro-2-(difluoromethoxy)phenol is partly driven by the increasing demand for fluorinated compounds in modern chemistry. Fluorine-containing molecules are known for their enhanced stability, bioavailability, and lipophilicity, which are critical factors in drug design and material science. Researchers and industry professionals frequently search for terms like "fluorinated phenol derivatives", "halogenated phenol synthesis", and "CAS 1261736-99-5 applications" to explore the potential of this compound. Its unique structure also makes it a subject of interest in green chemistry, where sustainable synthesis methods are prioritized.

One of the key advantages of 5-Chloro-2-(difluoromethoxy)phenol is its role as a building block in the synthesis of more complex molecules. For instance, it can serve as a precursor for the development of active pharmaceutical ingredients (APIs) or agrochemicals with improved efficacy. The difluoromethoxy group, in particular, is a sought-after moiety due to its ability to modulate the electronic and steric properties of molecules, making it a valuable tool for medicinal chemists. Searches related to "difluoromethoxy group in drug discovery" and "chlorophenol derivatives in agrochemicals" highlight the compound's relevance in these fields.

In addition to its synthetic utility, 5-Chloro-2-(difluoromethoxy)phenol has also been explored for its potential in material science. Fluorinated compounds are often used to enhance the performance of polymers, coatings, and electronic materials due to their thermal and chemical resistance. This has led to increased searches for terms like "fluorinated phenols in materials" and "CAS 1261736-99-5 material applications". The compound's ability to impart desirable properties to materials makes it a promising candidate for future innovations.

From a regulatory perspective, 5-Chloro-2-(difluoromethoxy)phenol is not classified as a hazardous substance under major global frameworks, which simplifies its handling and use in research and industrial settings. However, proper safety protocols should always be followed when working with any chemical compound. The compound's stability and relatively low toxicity profile make it an attractive option for laboratories and manufacturers looking to incorporate fluorinated motifs into their products.

As the scientific community continues to explore the potential of 5-Chloro-2-(difluoromethoxy)phenol, its applications are expected to expand further. Whether in the development of new pharmaceuticals, agrochemicals, or advanced materials, this compound exemplifies the importance of halogenated and fluorinated building blocks in modern chemistry. For researchers and industry professionals, staying updated on the latest developments related to CAS 1261736-99-5 and its derivatives is essential for leveraging its full potential.

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