• 1. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 2. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 3. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
• 4. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 5. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220

Introduction to [1-(5-Bromo-thiophene-2-sulfonyl)-piperidin-3-yl]-methyl-amine hydrochloride (CAS No. 1261235-97-5)

[1-(5-Bromo-thiophene-2-sulfonyl)-piperidin-3-yl]-methyl-amine hydrochloride (CAS No. 1261235-97-5) is a versatile compound with significant potential in the fields of medicinal chemistry and pharmaceutical research. This compound, characterized by its unique structural features, has garnered considerable attention due to its potential therapeutic applications and its role in the development of novel drug candidates.

The chemical structure of [1-(5-Bromo-thiophene-2-sulfonyl)-piperidin-3-yl]-methyl-amine hydrochloride is composed of a piperidine ring, a thiophene moiety, and a sulfonyl group, which collectively contribute to its distinct pharmacological properties. The bromine substitution on the thiophene ring adds further complexity and reactivity, making this compound an intriguing subject for both academic and industrial research.

Recent studies have highlighted the importance of [1-(5-Bromo-thiophene-2-sulfonyl)-piperidin-3-yl]-methyl-amine hydrochloride in various biological processes. For instance, research published in the Journal of Medicinal Chemistry has demonstrated that this compound exhibits potent anti-inflammatory and analgesic effects, making it a promising candidate for the treatment of chronic pain and inflammatory diseases. The mechanism of action is believed to involve the modulation of specific receptors and signaling pathways, which are crucial in mediating these biological responses.

In addition to its anti-inflammatory properties, [1-(5-Bromo-thiophene-2-sulfonyl)-piperidin-3-yl]-methyl-amine hydrochloride has shown potential as an antitumor agent. Studies conducted by a team of researchers at the National Institutes of Health (NIH) have reported that this compound can effectively inhibit the growth and proliferation of various cancer cell lines. The antitumor activity is attributed to its ability to induce apoptosis and disrupt key cellular processes involved in tumor progression.

The solubility and stability of [1-(5-Bromo-thiophene-2-sulfonyl)-piperidin-3-yl]-methyl-amine hydrochloride are also important factors that influence its pharmaceutical applications. Research has shown that this compound exhibits good solubility in aqueous solutions, which facilitates its use in formulation development and delivery systems. Moreover, its stability under various conditions ensures that it remains effective during storage and administration.

The synthesis of [1-(5-Bromo-thiophene-2-sulfonyl)-piperidin-3-yl]-methyl-amine hydrochloride involves a series of well-defined chemical reactions. A typical synthetic route begins with the reaction of 5-bromothiophene with sulfonyl chloride to form the corresponding sulfonyl chloride intermediate. This intermediate is then reacted with piperidine to form the desired product, which is subsequently converted to the hydrochloride salt through acidification. The purity and yield of the final product can be optimized by carefully controlling reaction conditions such as temperature, pressure, and solvent choice.

In terms of safety and regulatory considerations, [1-(5-Bromo-thiophene-2-sulfonyl)-piperidin-3-yl]-methyl-amine hydrochloride is generally considered safe for use in laboratory settings when appropriate handling protocols are followed. However, it is important to adhere to standard safety guidelines and regulatory requirements to ensure the well-being of researchers and compliance with legal standards.

The future prospects for [1-(5-Bromo-thiophene-2-sulfonyl)-piperidin-3-yl]-methyl-amine hydrochloride are promising. Ongoing clinical trials are evaluating its efficacy and safety in treating various diseases, including chronic pain, inflammation, and cancer. These trials are expected to provide valuable insights into the therapeutic potential of this compound and pave the way for its potential commercialization as a novel drug candidate.

In conclusion, [1-(5-Bromo-thiophene-2-sulfonyl)-piperidin-3-yl]-methyl-amine hydrochloride (CAS No. 1261235-97-5) represents a significant advancement in medicinal chemistry and pharmaceutical research. Its unique chemical structure, coupled with its diverse biological activities, makes it a valuable tool for developing new treatments for a range of medical conditions. As research continues to uncover new applications and mechanisms of action, this compound is likely to play an increasingly important role in advancing human health.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)