• 1. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 2. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 3. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 4. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 5. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789

Comprehensive Overview of 5-Bromomethyl-3,4-dichloropyridine (CAS No. 1260878-86-1): Properties, Applications, and Industry Insights

5-Bromomethyl-3,4-dichloropyridine (CAS No. 1260878-86-1) is a high-value heterocyclic compound widely utilized in pharmaceutical and agrochemical research. This brominated pyridine derivative features a unique molecular structure, combining a halogenated pyridine core with a reactive bromomethyl group, making it indispensable for cross-coupling reactions and intermediate synthesis. Its CAS registry number ensures precise identification in global chemical databases, while its molecular formula C6H4BrCl2N reflects its distinct composition.

The compound's chemical properties include a molecular weight of 240.92 g/mol and a purity typically exceeding 97%, as confirmed by HPLC analysis. Researchers value its solubility profile, showing good dissolution in polar organic solvents like dimethyl sulfoxide (DMSO) and dichloromethane, while remaining stable under inert atmospheres. Recent studies highlight its role in developing next-generation crop protection agents, aligning with the growing demand for sustainable agriculture solutions – a trending topic in 2024 scientific discussions.

In pharmaceutical applications, 5-Bromomethyl-3,4-dichloropyridine serves as a critical building block for kinase inhibitor development, particularly in oncology research. Its reactivity pattern enables efficient C-C bond formation through Buchwald-Hartwig amination or Suzuki-Miyaura coupling, processes frequently searched in organic synthesis forums. The compound's thermal stability (decomposition point >150°C) makes it suitable for high-temperature reactions, a feature emphasized in recent process chemistry optimization studies.

Quality control protocols for CAS 1260878-86-1 involve rigorous spectroscopic characterization, including 1H/13C NMR and mass spectrometry verification. The crystalline form typically displays a melting range of 89-92°C, with X-ray diffraction studies confirming its molecular packing arrangement. These physicochemical parameters are crucial for researchers comparing halopyridine analogs, a common query in structure-activity relationship investigations.

Emerging applications include its use in material science for constructing functionalized metal-organic frameworks (MOFs), addressing the current interest in porous materials for gas storage. The bromomethyl moiety facilitates post-synthetic modification of these frameworks, a technique gaining traction in nanotechnology research. This aligns with Google Trends data showing increased searches for "MOF functionalization methods" throughout 2024.

From a commercial perspective, 5-Bromomethyl-3,4-dichloropyridine manufacturers emphasize batch-to-batch consistency through advanced chromatographic purification techniques. Supply chain analytics reveal growing demand from contract research organizations (CROs) specializing in small molecule drug discovery, particularly for neglected tropical disease treatments – a humanitarian focus area receiving increased funding.

Environmental considerations include the compound's biodegradation profile, with recent OECD 301 testing indicating moderate persistence. This data supports proper laboratory waste management procedures, a compliance aspect heavily searched by EHS professionals. The electrophilic character of the molecule warrants standard personal protective equipment during handling, consistent with green chemistry principles increasingly adopted by research institutions.

Innovative synthetic approaches to 1260878-86-1 now incorporate continuous flow chemistry methods, reducing solvent consumption by 40-60% compared to batch processes. This advancement responds to industry demands for process intensification, a key term in chemical engineering literature. Patent analysis shows growing IP activity around pyridine derivative synthesis, particularly in Asian pharmaceutical markets.

Analytical challenges include distinguishing regioisomeric impurities during quality assurance testing. Advanced UHPLC-MS methods now achieve baseline separation of structurally similar byproducts, addressing a common pain point discussed in analytical chemistry communities. The compound's UV absorption maxima at 274 nm facilitates photochemical studies, an area gaining interest for light-mediated reactions in drug discovery.

Future research directions may explore catalytic bromination methods for more sustainable production, aligning with the 12 Principles of Green Chemistry. The compound's potential in bioconjugation chemistry also warrants investigation, particularly for developing antibody-drug conjugates – a therapeutic modality showing exponential growth in clinical pipelines. These applications position 5-Bromomethyl-3,4-dichloropyridine as a versatile tool for addressing current challenges in medicinal chemistry and material design.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)