Cas no 1260761-45-2 (tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate)

Tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate is a versatile intermediate in organic synthesis, particularly valuable in pharmaceutical and agrochemical research. The presence of both a hydroxymethyl and a trifluoromethyl group on the piperidine ring enhances its utility as a building block for bioactive molecules. The tert-butyloxycarbonyl (Boc) protecting group ensures stability during synthetic transformations while allowing selective deprotection when required. Its trifluoromethyl moiety contributes to improved metabolic stability and lipophilicity in derived compounds. This compound is particularly useful in the development of CNS-targeting drugs and enzyme inhibitors due to its structural flexibility and functional group compatibility. Its high purity and well-defined reactivity make it a reliable choice for medicinal chemistry applications.
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate structure
1260761-45-2 structure
Product Name:tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
CAS No:1260761-45-2
MF:C12H20F3NO3
MW:283.287314414978
CID:5018941
Update Time:2026-02-28

tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate Chemical and Physical Properties

Names and Identifiers

    • tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
    • CID 53404345
    • 4-Hydroxymethyl-3-trifluoromethyl-piperidine-1-carboxylic acid tert-butyl ester
    • MDL: MFCD11848144
    • Inchi: 1S/C12H20F3NO3/c1-11(2,3)19-10(18)16-5-4-8(7-17)9(6-16)12(13,14)15/h8-9,17H,4-7H2,1-3H3
    • InChI Key: JBUVCFWMXNCZDQ-UHFFFAOYSA-N
    • SMILES: FC(C1CN(C(=O)OC(C)(C)C)CCC1CO)(F)F

Computed Properties

  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 19
  • Rotatable Bond Count: 3
  • Complexity: 325
  • XLogP3: 2.2
  • Topological Polar Surface Area: 49.8

tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PBZ5391-100MG
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
1260761-45-2 95%
100MG
¥ 1,412.00 2023-03-31
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PBZ5391-250MG
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
1260761-45-2 95%
250MG
¥ 2,257.00 2023-03-31
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PBZ5391-500MG
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
1260761-45-2 95%
500MG
¥ 3,755.00 2023-03-31
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PBZ5391-1G
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
1260761-45-2 95%
1g
¥ 5,629.00 2023-03-31
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PBZ5391-5G
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
1260761-45-2 95%
5g
¥ 16,889.00 2023-03-31
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PBZ5391-100mg
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
1260761-45-2 95%
100mg
¥1387.0 2024-04-25
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PBZ5391-250mg
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
1260761-45-2 95%
250mg
¥2216.0 2024-04-25
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PBZ5391-500mg
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
1260761-45-2 95%
500mg
¥3687.0 2024-04-25
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PBZ5391-1g
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
1260761-45-2 95%
1g
¥5528.0 2024-04-25
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PBZ5391-5g
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
1260761-45-2 95%
5g
¥16583.0 2024-04-25

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