Cas no 1260761-45-2 (tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate)
Tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate is a versatile intermediate in organic synthesis, particularly valuable in pharmaceutical and agrochemical research. The presence of both a hydroxymethyl and a trifluoromethyl group on the piperidine ring enhances its utility as a building block for bioactive molecules. The tert-butyloxycarbonyl (Boc) protecting group ensures stability during synthetic transformations while allowing selective deprotection when required. Its trifluoromethyl moiety contributes to improved metabolic stability and lipophilicity in derived compounds. This compound is particularly useful in the development of CNS-targeting drugs and enzyme inhibitors due to its structural flexibility and functional group compatibility. Its high purity and well-defined reactivity make it a reliable choice for medicinal chemistry applications.
1260761-45-2 structure
Product Name:tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
CAS No:1260761-45-2
MF:C12H20F3NO3
MW:283.287314414978
CID:5018941
Update Time:2026-02-28
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate Chemical and Physical Properties
Names and Identifiers
-
- tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate
- CID 53404345
- 4-Hydroxymethyl-3-trifluoromethyl-piperidine-1-carboxylic acid tert-butyl ester
-
- MDL: MFCD11848144
- Inchi: 1S/C12H20F3NO3/c1-11(2,3)19-10(18)16-5-4-8(7-17)9(6-16)12(13,14)15/h8-9,17H,4-7H2,1-3H3
- InChI Key: JBUVCFWMXNCZDQ-UHFFFAOYSA-N
- SMILES: FC(C1CN(C(=O)OC(C)(C)C)CCC1CO)(F)F
Computed Properties
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 19
- Rotatable Bond Count: 3
- Complexity: 325
- XLogP3: 2.2
- Topological Polar Surface Area: 49.8
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBZ5391-100MG |
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate |
1260761-45-2 | 95% | 100MG |
¥ 1,412.00 | 2023-03-31 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBZ5391-250MG |
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate |
1260761-45-2 | 95% | 250MG |
¥ 2,257.00 | 2023-03-31 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBZ5391-500MG |
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate |
1260761-45-2 | 95% | 500MG |
¥ 3,755.00 | 2023-03-31 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBZ5391-1G |
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate |
1260761-45-2 | 95% | 1g |
¥ 5,629.00 | 2023-03-31 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBZ5391-5G |
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate |
1260761-45-2 | 95% | 5g |
¥ 16,889.00 | 2023-03-31 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBZ5391-100mg |
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate |
1260761-45-2 | 95% | 100mg |
¥1387.0 | 2024-04-25 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBZ5391-250mg |
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate |
1260761-45-2 | 95% | 250mg |
¥2216.0 | 2024-04-25 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBZ5391-500mg |
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate |
1260761-45-2 | 95% | 500mg |
¥3687.0 | 2024-04-25 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBZ5391-1g |
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate |
1260761-45-2 | 95% | 1g |
¥5528.0 | 2024-04-25 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBZ5391-5g |
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate |
1260761-45-2 | 95% | 5g |
¥16583.0 | 2024-04-25 |
tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate Related Literature
-
Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
-
Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
-
Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
-
P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
-
Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
1260761-45-2 (tert-butyl 4-(hydroxymethyl)-3-(trifluoromethyl)piperidine-1-carboxylate) Related Products
- 1283719-66-3(3-Hydroxymethyl-3-methyl-4-trifluoromethyl-pyrrolidine-1-carboxylic acid tert-butyl ester)
- 1817633-15-0(tert-butyl trans-3-(hydroxymethyl)-4-(trifluoromethyl)pyrrolidine-1-carboxylate)
- 1260893-18-2(Tert-butyl 4-(hydroxymethyl)-4-(trifluoromethyl)piperidine-1-carboxylate)
- 1260761-49-6(Tert-butyl 4-(aminomethyl)-3-(trifluoromethyl)piperidine-1-carboxylate)
- 1093759-71-7(tert-Butyl 3-(Trifluoromethyl)piperidine-1-carboxylate)
- 1283720-71-7(Tert-butyl 4-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate)
- 1260789-12-5(tert-butyl 3-(hydroxymethyl)-4-(trifluoromethyl)pyrrolidine-1-carboxylate)
- 2008714-26-7(Trans-Tert-Butyl 3-(Hydroxymethyl)-4-(Trifluoromethyl)Pyrrolidine-1-Carboxylate)
- 1211578-36-7(tert-butyl 4-(aminomethyl)-4-(trifluoromethyl)piperidine-1-carboxylate)
- 1255098-67-9(tert-butyl 4-amino-3-(trifluoromethyl)piperidine-1-carboxylate)
Recommended suppliers
Handan Zechi Trading Co., Ltd
Gold Member
CN Supplier
Bulk
Shanghai Pearlk Chemicals Co., Ltd.
Gold Member
CN Supplier
Bulk
Jiangsu Kolod Food Ingredients Co.,ltd
Gold Member
CN Supplier
Bulk
Beyond Pharmaceutical Co., Ltd
Gold Member
CN Supplier
Reagent
Zhangzhou Sinobioway Peptide Co.,Ltd.
Gold Member
CN Supplier
Reagent