• 1. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
• 4. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 5. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548

CIS-3-FLUOROCYCLOBUTANAMINE (CAS No. 1260670-54-9): A Comprehensive Overview in Modern Chemical Biology

CIS-3-FLUOROCYCLOBUTANAMINE, identified by the chemical identifier CAS No. 1260670-54-9, represents a novel compound of significant interest in the realm of chemical biology and pharmaceutical research. This bicyclic amine derivative features a fluorinated cyclobutane core, which has garnered attention due to its unique structural and electronic properties. The presence of a fluorine atom at the 3-position introduces a distinct level of reactivity and potential utility in medicinal chemistry, particularly in the design of bioactive molecules.

The structural motif of CIS-3-FLUOROCYCLOBUTANAMINE is characterized by its rigid cyclobutane ring system, which is further modulated by the incorporation of a fluorine substituent. This modification imparts a degree of electronic and steric influence that can be leveraged to fine-tune the interactions of the molecule with biological targets. The fluorine atom, being highly electronegative, can enhance binding affinity and metabolic stability, making it an attractive feature for drug development.

In recent years, there has been a growing interest in fluorinated heterocycles as pharmacophores due to their ability to modulate pharmacokinetic properties and improve therapeutic efficacy. CIS-3-FLUOROCYCLOBUTANAMINE exemplifies this trend, as its cyclobutane scaffold provides a stable framework for further functionalization while the fluorine atom offers opportunities for selective interactions with biological receptors. This compound has been explored in various contexts, including its potential applications in the development of small-molecule inhibitors and probes for studying biological pathways.

One of the most compelling aspects of CIS-3-FLUOROCYCLOBUTANAMINE is its versatility in synthetic chemistry. The cyclobutane ring can serve as a versatile scaffold for introducing diverse substituents, allowing chemists to tailor the molecule for specific biological activities. Recent studies have demonstrated that derivatives of this compound can exhibit inhibitory effects on certain enzymes and receptors, making them promising candidates for therapeutic intervention. For instance, modifications at the 3-position have been shown to enhance binding to target proteins, suggesting potential applications in treating various diseases.

The fluorine atom in CIS-3-FLUOROCYCLOBUTANAMINE also contributes to its stability under physiological conditions, which is a critical factor in drug design. Fluorinated compounds often exhibit improved bioavailability and resistance to metabolic degradation, thereby extending their therapeutic window. This property has been exploited in the development of numerous drugs that incorporate fluorine atoms into their structures. The incorporation of such moieties into CIS-3-FLUOROCYCLOBUTANAMINE derivatives could lead to novel therapeutics with enhanced pharmacological profiles.

Advances in computational chemistry have further facilitated the exploration of CIS-3-FLUOROCYCLOBUTANAMINE and its derivatives. Molecular modeling techniques have been employed to predict binding affinities and interactions with biological targets, enabling rational drug design. These computational approaches have helped identify key structural features that contribute to the biological activity of this compound, guiding synthetic efforts toward more effective derivatives.

In addition to its potential as a drug candidate, CIS-3-FLUOROCYCLOBUTANAMINE has found utility as a building block in synthetic chemistry. Its unique structure allows for diverse functionalizations, making it a valuable intermediate in the synthesis of more complex molecules. Researchers have utilized this compound to construct novel heterocyclic frameworks, which have shown promise in various applications, including material science and agrochemicals.

The role of fluorine-containing compounds in medicinal chemistry continues to expand, driven by their unique properties and broad range of applications. CIS-3-FLUOROCYCLOBUTANAMINE, with its well-defined structure and versatile reactivity, stands out as a promising candidate for further exploration. As research progresses, new applications and derivatives are likely to emerge, reinforcing its importance in both academic and industrial settings.

In conclusion, CIS-3-FLUOROCYCLOBUTANAMINE (CAS No. 1260670-54-9) represents a significant advancement in chemical biology and pharmaceutical research. Its unique structural features, combined with the versatility of its synthetic chemistry, make it a valuable tool for drug discovery and molecular construction. As our understanding of fluorinated heterocycles grows, so too does the potential of compounds like CIS-3-FLUOROCYCLOBUTANAMINE to contribute to innovative therapies and scientific breakthroughs.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)