• 1. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 2. An apparatus for testing water by measurement of its electrical conductivity
  Analyst, 1912,37, 538-543
• 3. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 4. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 5. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219

7-Fluoro-5-iodo-1H-indazole (CAS No. 1260381-29-0): A Versatile Building Block in Medicinal Chemistry and Drug Discovery

The compound 7-Fluoro-5-iodo-1H-indazole (CAS No. 1260381-29-0) is a highly specialized heterocyclic molecule that has garnered significant attention in the fields of medicinal chemistry, pharmaceutical research, and organic synthesis. With its unique fluoro and iodo substituents, this indazole derivative serves as a critical intermediate for the development of novel therapeutics, particularly in oncology and neurology. Its molecular structure, characterized by a fused benzene and pyrazole ring, offers exceptional versatility for further functionalization, making it a prized asset in modern drug discovery pipelines.

In recent years, the demand for 7-Fluoro-5-iodo-1H-indazole has surged due to its role in targeting kinase inhibitors and GPCR modulators, two of the most sought-after drug classes in precision medicine. Researchers are particularly intrigued by its potential applications in cancer immunotherapy and neurodegenerative disease research, aligning with trending topics like personalized medicine and AI-driven drug design. The compound’s iodo moiety also facilitates cross-coupling reactions, enabling rapid diversification in combinatorial chemistry libraries—a feature highly valued in high-throughput screening (HTS) campaigns.

From a synthetic perspective, 7-Fluoro-5-iodo-1H-indazole exemplifies the growing importance of halogenated heterocycles in fragment-based drug discovery (FBDD). Its fluorine atom enhances metabolic stability and bioavailability, addressing common challenges in lead optimization. Meanwhile, the iodine substituent provides a handle for late-stage modifications via palladium-catalyzed couplings, such as Suzuki-Miyaura or Sonogashira reactions. These attributes make it a staple in the toolkit of chemists working on proteolysis-targeting chimeras (PROTACs) and covalent inhibitors—areas dominating recent literature and patent filings.

The compound’s relevance extends to diagnostic imaging, where its radioisotope-labeled analogs are explored for positron emission tomography (PET) tracers. This aligns with the rising interest in theranostics, a fusion of therapy and diagnostics, which is a hot topic in both academic and industrial circles. Furthermore, its structural motif is frequently cited in studies investigating allosteric modulation and protein-protein interaction inhibitors, reflecting broader shifts toward targeting undruggable pathways.

Quality and sourcing of 7-Fluoro-5-iodo-1H-indazole are paramount, given its role in cutting-edge research. Reputable suppliers emphasize HPLC purity and batch-to-batch consistency, ensuring reproducibility in sensitive assays. As the pharmaceutical industry increasingly adopts green chemistry principles, synthetic routes for this compound are being optimized to reduce heavy metal residues and solvent waste—addressing ESG (Environmental, Social, and Governance) concerns now prevalent in investor discussions.

In summary, 7-Fluoro-5-iodo-1H-indazole (CAS No. 1260381-29-0) stands at the intersection of innovation and utility, bridging gaps between synthetic chemistry and translational medicine. Its multifaceted applications—from small-molecule probes to preclinical candidates—underscore its enduring value in a rapidly evolving scientific landscape. For researchers navigating the complexities of structure-activity relationships (SAR) or hit-to-lead optimization, this compound remains an indispensable resource.

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