Cas no 1260374-05-7 ((4-(Methoxymethoxy)-2-methylphenyl)boronic acid)

(4-(Methoxymethoxy)-2-methylphenyl)boronic acid is a versatile boronic acid derivative widely used in Suzuki-Miyaura cross-coupling reactions, a key method for forming carbon-carbon bonds in organic synthesis. The compound features a methoxymethoxy-protected hydroxyl group at the para position and a methyl substituent at the ortho position relative to the boronic acid functionality, enhancing its stability and reactivity. This structural modification improves solubility in common organic solvents and reduces protodeboronation, a common side reaction in boronic acid chemistry. Its electron-rich aromatic system facilitates efficient transmetalation in palladium-catalyzed coupling reactions, making it valuable for constructing complex biaryl structures in pharmaceuticals, agrochemicals, and materials science. The protecting group can be selectively removed under mild acidic conditions, offering additional synthetic flexibility.
(4-(Methoxymethoxy)-2-methylphenyl)boronic acid structure
1260374-05-7 structure
Product Name:(4-(Methoxymethoxy)-2-methylphenyl)boronic acid
CAS No:1260374-05-7
MF:C9H13BO4
MW:196.008123159409
MDL:MFCD11111901
CID:1026321
Update Time:2025-07-02

(4-(Methoxymethoxy)-2-methylphenyl)boronic acid Chemical and Physical Properties

Names and Identifiers

    • (4-(Methoxymethoxy)-2-methylphenyl)boronic acid
    • [4-(Methoxymethoxy)-2-methylphenyl]boronic acid
    • MDL: MFCD11111901
    • Inchi: 1S/C9H13BO4/c1-7-5-8(14-6-13-2)3-4-9(7)10(11)12/h3-5,11-12H,6H2,1-2H3
    • InChI Key: CLCGIQQHHJUZFU-UHFFFAOYSA-N
    • SMILES: O(COC)C1C=CC(B(O)O)=C(C)C=1

Computed Properties

  • Exact Mass: 196.09100
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 4

Experimental Properties

  • PSA: 58.92000
  • LogP: -0.34250

(4-(Methoxymethoxy)-2-methylphenyl)boronic acid Pricemore >>

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