• 1. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 2. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 3. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207
• 4. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 5. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives Chlorinated biphenyls

Comprehensive Overview of 3-(2-Chloro-4-methylphenyl)-5-hydroxybenzoic acid (CAS No. 1258622-09-1): Properties, Applications, and Industry Insights

3-(2-Chloro-4-methylphenyl)-5-hydroxybenzoic acid (CAS No. 1258622-09-1) is a specialized organic compound gaining attention in pharmaceutical and agrochemical research due to its unique structural features. This hydroxybenzoic acid derivative combines a chloro-substituted aromatic ring with a carboxyl group, making it a versatile intermediate for synthesizing bioactive molecules. Researchers are particularly interested in its potential as a building block for drug discovery, especially in developing anti-inflammatory and antimicrobial agents.

The compound's molecular structure features a chloro-methylphenyl group at the 3-position and a hydroxyl group at the 5-position of the benzoic acid core, creating distinct electronic properties. This configuration influences its solubility profile and reactivity patterns, which are critical for formulation scientists. Recent studies highlight its utility in creating targeted drug delivery systems, where the hydroxyl group serves as an attachment point for prodrug strategies. The CAS No. 1258622-09-1 has become a frequent search term among medicinal chemists exploring structure-activity relationships in small molecule therapeutics.

In material science applications, 3-(2-Chloro-4-methylphenyl)-5-hydroxybenzoic acid demonstrates promise as a monomer for specialty polymers. Its dual functional groups allow for copolymerization with various substrates, yielding materials with tailored thermal and mechanical properties. Industry reports suggest growing demand for this compound in developing high-performance coatings and electronic materials, particularly in the renewable energy sector where stable organic matrices are needed for photovoltaic applications.

Analytical characterization of CAS No. 1258622-09-1 typically involves advanced techniques such as HPLC-MS and NMR spectroscopy. The compound shows characteristic peaks in the aromatic region (7-8 ppm in ¹H NMR) and distinctive fragmentation patterns in mass spectrometry. These analytical signatures are crucial for quality control in GMP-compliant synthesis, especially when the material is intended for pharmaceutical use. Recent method development publications emphasize optimized chromatographic separation protocols for this compound and its derivatives.

Environmental and safety assessments of 3-(2-Chloro-4-methylphenyl)-5-hydroxybenzoic acid indicate it requires standard laboratory handling precautions. While not classified as highly hazardous, proper personal protective equipment (PPE) including gloves and eye protection is recommended during manipulation. The compound's biodegradation profile and ecotoxicological data have become increasingly relevant topics in green chemistry forums, reflecting the industry's shift toward sustainable practices.

Market intelligence reveals expanding applications of CAS No. 1258622-09-1 in crop protection formulations. Its structural motifs appear in several patent filings for next-generation plant growth regulators and fungicidal agents. Agricultural researchers are investigating its role in combating resistant fungal strains, a pressing concern in modern agriscience. This application aligns with current trends toward precision agriculture and reduced environmental impact of agrochemicals.

The synthesis of 3-(2-Chloro-4-methylphenyl)-5-hydroxybenzoic acid typically proceeds through multi-step organic transformations involving Friedel-Crafts acylation and subsequent functional group modifications. Recent process chemistry publications describe improved catalytic methods that enhance yield and purity while reducing waste generation. These advancements address the pharmaceutical industry's need for cost-effective synthetic routes to complex intermediates.

From a regulatory perspective, CAS No. 1258622-09-1 currently falls under general chemical classification schemes in most jurisdictions. However, manufacturers should monitor evolving REACH compliance requirements and global harmonization initiatives that may affect its status. The compound's patent landscape shows active development, particularly in Asia-Pacific markets where innovation in fine chemicals is accelerating.

Emerging research explores the compound's potential in bioconjugation chemistry and proteolysis-targeting chimeras (PROTACs). Its ability to serve as a linker molecule in these advanced therapeutic modalities has sparked interest among biopharmaceutical companies. This application represents a convergence with current drug discovery trends focusing on targeted protein degradation and modular drug design.

Quality specifications for 3-(2-Chloro-4-methylphenyl)-5-hydroxybenzoic acid vary by application, with pharmaceutical-grade material typically requiring ≥98% purity by HPLC. Analytical certificates should include detailed impurity profiles and residual solvent analysis. Storage recommendations generally suggest protection from light and moisture at controlled temperatures to maintain stability, particularly for long-term research samples.

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